Analysis of Antibiotic Treatment and Microbiological Findings and Its Implication on Outcome in Patients with Parapneumonic Effusions

Sanja Petrusevska-Marinkovic

doi:10.3889/oamjms.2024.11936

Authors

Sanja Petrusevska-Marinkovic Department of Infectious Diseases, University Clinic for Respiratory Diseases in Children “Kozle”- Skopje, Republic of North Macedonia; Department of Infectious Diseases, Medical Faculty, Ss. Cyril and Methodius University of Skopje, Skopje, Republic of North Macedonia https://orcid.org/0009-0009-3224-2016

DOI:

https://doi.org/10.3889/oamjms.2024.11936

Keywords:

uncomplicated parapneumonic effusion, complicated parapneumonic effusion, empyema, community-acquired pneumonia, antibiotic treatment, microbiology, length of hospitalization

Abstract

BACKGROUND: Parapneumonic effusion (PPE), as a complication of community-acquired pneumonia, sometimes progresses into complicated PPE (CPPE) and empyema, thus becoming a significant clinical problem. There is a lack of guidelines for antibiotic therapy and reports on local microbiological status and resistance of microorganisms.

AIM: Тhe paper is focused on the analysis of antibiotic therapy and microbiological findings that are affecting patient outcomes and length of treatment.

METHODS: We analyzed 94 patients, 50 with uncomplicated PPE (UCPPE) and 44 with CPPEs.

RESULTS: More patients (59.57%) were male, average age 53.82 ± 17.5 years. Alcoholism was the most common comorbidity in patients with CPPE registered in 25% of patients. A positive pleural punctate culture was present in 31.82% of patients with CPPE. Peptostreptococcus was most often isolated in 28.57%. Blood culture was positive in 12.76% of patients. Most of the patients were treated with combined therapy that also covered anerobes (64.89%). Statistical differences existed in terms of days of hospital treatment with a longer hospital stay for patients with CPPE (p < 0.0001). The average time of hospital treatment in patients with UCPPE was 15 days, and in patients with CPPE, it was 21 days.

CONCLUSION: As soon as a pleural infection is noted, patients should receive antibiotic therapy, which should be based on pleural fluid culture. Anerobic coverage is required. In this way, the development of CPPE and empyema will be prevented, and thus, mortality and long hospital stays will be reduced.

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