Clinical Characteristics and Some Related Factors in Children with Prurigo Nodularis in Vietnam

Sar  Sokpharuth; Thi Huyen Tran

doi:10.3889/oamjms.2024.11955

Authors

Sar Sokpharuth Department of Dermatology and Venereology, Hanoi Medical University, Hanoi, Vietnam; Svay Rieng Provincial Hospital, Svay Rieng Province, Cambodia https://orcid.org/0009-0007-3632-1892
Thi Huyen Tran Svay Rieng Provincial Hospital, Svay Rieng Province, Cambodia; Department of Outpatient, National Hospital of Dermatology and Venereology, Hanoi, Vietnam https://orcid.org/0000-0002-9794-5718

DOI:

https://doi.org/10.3889/oamjms.2024.11955

Keywords:

Clinical characteristics, Children, Prurigo nodularis, Related factors, Treatment

Abstract

BACKGROUND: Prurigo nodularis in children can become chronic, lasting from several months to many years, triggered and sustained by environmental allergens. In Vietnam, prurigo nodularis is relatively common; however, few studies have been conducted on pediatric populations.

AIMS: This study aims to describe the clinical characteristics and related factors of prurigo nodularis in children.

METHODS: This prospective, cross-sectional descriptive study was conducted at the National Hospital of Dermatology and Venereology from December 2023 to June 2024. A total of 117 children participated in the study. Data were collected according to the study’s medical record template.

RESULTS: The results showed that the proportion of male patients was higher than that of female patients (62.4% vs. 37.6%), with the highest proportion of cases in the under-6 age group (47%). Most patients lived in urban areas (88%). Nearly half of the cases had disease duration of < 12 months (42.2%). The onset rate on the legs was the highest (58.2%). Some related factors were herbal baths (1.7%), food allergies (8.5%), pet keeping (22.2%), insect bites (23.1%), family history of prurigo (24.8%), long fingernails (59.8%), and self-medication (73.5%). The rate of regular deworming was 93.2% of the children. Most patients experienced severe itching (97.4%), with the severity and activity level of the disease mainly at moderate levels (96.6% and 97.4%, respectively).

CONCLUSION: Prurigo nodularis in children presents with diverse clinical characteristics. Factors such as food allergies, pet keeping, insect bites, and family history may play a role in triggering and maintaining the disease, but further research is needed.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Satoh T, Yokozeki H, Murota H, Tokura Y, Kabashima K, Takamori K, et al. 2020 guidelines for the diagnosis and treatment of prurigo. J Dermatol. 2021;48(9):e414-31. https://doi.org/10.1111/1346-8138.16067 PMid: 34314056 DOI: https://doi.org/10.1111/1346-8138.16067

Williams KA, Roh YS, Brown I, Sutaria N, Bakhshi P, Choi J, et al. Pathophysiology, diagnosis, and pharmacological treatment ofprurigonodularis.ExpertRevClinPharmacol.2021;14(1):67-77. https://doi.org/10.1080/17512433.2021.1852080 PMid:33191806 DOI: https://doi.org/10.1080/17512433.2021.1852080

Dégboé B, Koudoukpo C, Maffo N, Otémé S, Kouassi A, Akpadjan F, et al. Prurigo in children of tropical zone: Epidemiological, clinical, and etiological characteristics in a dermatology department in Cotonou (Benin). Dermatol Res Pract. 2019;2019:2673981. https://doi.org/10.1155/2019/2673981 PMid:31781184 DOI: https://doi.org/10.1155/2019/2673981

Albela H, Leong KF. Early-onset, severe prurigo nodularis in a young child with atopic dermatitis treated successfully with dupilumab. Indian J Paediatr Dermatol. 2022;23(2):170-1. https://doi.org/10.4103/ijpd.ijpd_175_21 DOI: https://doi.org/10.4103/ijpd.ijpd_175_21

Oliveira J, Nogueira M, Pinto D, Machado S, Araújo AR, Teixeira F. Role of dupilumab in pediatric prurigo nodularis: Beyond the skin. Pediatr Allergy Immunol. 2023;34(1):e13912. https://doi.org/10.1111/pai.13912 PMid:36705041 DOI: https://doi.org/10.1111/pai.13912

Huang AH, Roh YS, Sutaria N, Choi J, Williams KA, Pritchard T, et al. Real-world disease burden and comorbidities of pediatric prurigo nodularis. J Am Acad Dermatol. 2022;86(3):655-7. https://doi.org/10.1016/j.jaad.2021.02.030 PMid:33600911 DOI: https://doi.org/10.1016/j.jaad.2021.02.030

Qureshi AA, Abate LE, Yosipovitch G, Friedman AJ. A systematic review of evidence-based treatments for prurigo nodularis. J Am Acad Dermatol. 2019;80(3):756-64. https://doi.org/10.1016/j.jaad.2018.09.020 PMid:30261199 DOI: https://doi.org/10.1016/j.jaad.2018.09.020

Thai NQ. Study on the association between prurigo nodularis and metabolic diseases at the department of Dermatology, Thai Nguyen hospital. Vietnamese J Dermatol Venereol. 2012;2:8-16.

Zeidler C, Yosipovitch G, Ständer S. Prurigo nodularis and its management. Dermatol Clin. 2018;36(3):189-97. https://doi.org/10.1016/j.det.2018.02.003 PMid:29929592 DOI: https://doi.org/10.1016/j.det.2018.02.003

Kwon CD, Khanna R, Williams KA, Kwatra MM, Kwatra SG. Diagnostic workup and evaluation of patients with prurigo nodularis. Medicines (Basel). 2019;6(4):97. https://doi.org/10.3390/medicines6040097 PMid:31561504 DOI: https://doi.org/10.3390/medicines6040097

Yosipovitch G, Reaney M, Mastey V, Eckert L, Abbé A, Nelson L, et al. Peak pruritus numerical rating scale: Psychometric validation and responder definition for assessing itch in moderate-to-severe atopic dermatitis. Br J Dermatol. 2019;181(4):761-9. https://doi.org/10.1111/bjd.17744 PMid:30729499 DOI: https://doi.org/10.1111/bjd.17744

Zeidler C, Pereira MP, Augustin M, Spellman M, Ständer S. Investigator’s global assessment of chronic prurigo: A new instrument for use in clinical trials. Acta Derm Venereol. 2021;101(2):adv00401. https://doi.org/10.2340/00015555-3701 PMid:33236125 DOI: https://doi.org/10.2340/00015555-3701

Maridet C, Perromat M, Miquel J, Chiaverini C, Bessis D, Lasek A, et al. Childhood chronic prurigo: Interest in patch tests and delayed-reading skin prick tests to environmental allergens. J Allergy Clin Immunol. 2018;141(2):797-9.e9. https://doi.org/10.1016/j.jaci.2017.07.049 PMid:28943471 DOI: https://doi.org/10.1016/j.jaci.2017.07.049

Iking A, Grundmann S, Chatzigeorgakidis E, Phan NQ, Klein D, Ständer S. Prurigo as a symptom of atopic and non- atopic diseases: Aetiological survey in a consecutive cohort of 108 patients. J Eur Acad Dermatol Venereol. 2013;27(5):550-7. https://doi.org/10.1111/j.1468-3083.2012.04481.x PMid:22364653 DOI: https://doi.org/10.1111/j.1468-3083.2012.04481.x

Pereira MP, Lüling H, Dieckhöfer A, Steinke S, Zeidler C, Ständer S. Brachioradial pruritus and notalgia paraesthetica: A comparative observational study of clinical presentation and morphological pathologies.Acta Derm Venereol. 2018;98(1):82-8. https://doi.org/10.2340/00015555-2789 PMid:28902951 DOI: https://doi.org/10.2340/00015555-2789

Hughes JDM, Woo TE, Belzberg M, Khanna R, Williams KA, Kwatra MM, et al. Association between prurigo nodularis and etiologies of peripheral neuropathy: Suggesting a role for neural dysregulation in pathogenesis. Medicines (Basel). 2020;7(1):4. https://doi.org/10.3390/medicines7010004 PMid:31936197 DOI: https://doi.org/10.3390/medicines7010004