Impact of the Maternal and/or Infant Elimination Diet on Infants with Gastroesophageal Reflux Disease

Authors

  • Osama El-Asheer Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt https://orcid.org/0000-0002-5844-5104
  • Hoda A. Abdelsattar Pediatric Clinical Nutrition Unit, Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt
  • Atef A. Mahmoud Pediatric Department, Faculty of Medicine, Aswan University, Aswan, Egypt
  • Hanan M Aly Pediatric Department, Faculty of Medicine, Aswan University, Aswan, Egypt
  • Mohammed B El-Amir Pediatric Department, Faculty of Medicine, Aswan University, Aswan, Egypt

DOI:

https://doi.org/10.3889/oamjms.2024.11967

Keywords:

GERD, CMPA, elimination, diet, infants, maternal

Abstract

BACKGROUND: Infantile gastroesophageal reflux disease (GERD) and cow milk protein allergy (CMPA) are common conditions. There is a potential link between these two disorders.

AIM: To outline the possible impact of the maternal and /or infant elimination diet on improving GERD manifestations in infants.

MATERIALS AND METHODS: This was a retrospective cohort study that was conducted in the General Pediatric outpatient clinics at Aswan University investigating the possible positive effect of the maternal and/or infant elimination diet on outcomes of GERD in infants.

RESULTS: Forty -five infants were enrolled in our study. A significant difference (P value =0.001) regards the frequencies of spitting at presentation and the fourth week of follow-up was noticed (Median (IQR)= 5 (3), 4 (3) respectively).  A significant decline in aspirations was detected (P value =0.001). The overall prevalence of CMPA in infants with GERD in our study was 33%.

CONCLUSION: It seems that the maternal and /or infant elimination diet could be a potential therapeutic modality for infants with GERD.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Heine RG.: Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Current opinion in allergy and clinical immunology. 2006:Jun 1;6(3):220-5. https://doi.org/10.1097/01

Nielsen RG, Bindslev-Jensen C, Kruse-Andersen S, Husby S.: Severe gastroesophageal reflux disease and cow milk hypersensitivity in infants and children: disease association and evaluation of a new challenge procedure. Journal of pediatric gastroenterology and nutrition. 2004 Oct 1;39(4):383-91. https://doi.org/10.1097/00005176-200410000-00015 PMid:15448429

Rajani PS, Martin H, Groetch M, Järvinen KM.:Presentation and management of food allergy in breastfed infants and risks of maternal elimination diets. The Journal of Allergy and Clinical Immunology: In Practice. 2020 Jan 1;8(1):52-67. https://doi.org/10.1016/j.jaip.2019.11.007 PMid:31751757

Labrosse R, Graham F, Caubet JC.: Non-IgE-mediated gastrointestinal food allergies in children: an update. Nutrients. 2020 Jul 14;12(7):2086. https://doi.org/10.3390/nu12072086 PMid:32674427 PMCid:PMC7400851

Czinn SJ, Blanchard S.: Gastroesophageal Reflux Disease in Neonates and Infants. Paediatr. Drugs.2013 Sep 8;15:19-27. https://doi.org/10.1007/s40272-012-0004-2 PMid:23322552

Parikh T.: Prevalence and impact of Gastroesophageal Reflux Disease in Infants and Children. Int Clin Img and Med Rew. 2023;4(2):1145. https://doi.org/10.55920/IJCIMR.2023.04.001145

Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N.: Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Journal of pediatric gastroenterology and nutrition. 2018 Mar 1;66(3):516-54. https://doi.org/10.1097/MPG.0000000000001889 PMid:29470322 PMCid:PMC5958910

Bajerova K, Salvatore S, Dupont C, Eigenmann P, Kuitunen M, Meyer R, Ribes-Koninckx C, Shamir R, Szajewska H, Vandenplas Y.: The cow's milk-related symptom score (CoMiSS™): a useful awareness tool. Nutrients. 2022 May 14;14(10):2059. https://doi.org/10.3390/nu14102059 PMid:35631201 PMCid:PMC9146599

Saad K, Elgenidy A, Atef M, Abdelsattar MK, Al-Ashwah M, Hammad EM, Ahmed FA, Aboelgheet A, Elfarargy MS, Ali AM, El-Ashry AH.: Cow's milk-related symptom score for cow's milk allergy assessment: a meta-analysis for test accuracy. Pediatric Research. 2023 Mar;93(4):772-9. https://doi.org/10.1038/s41390-022-02334-y PMid:36253506

Mayerhofer C, Kavallar AM, Aldrian D, Lindner AK, Müller T, Vogel GF.: Efficacy of elimination diets in eosinophilic esophagitis: a systematic review and meta-analysis. Clinical Gastroenterology and Hepatology. 2023 Aug 1;21(9):2197-210. https://doi.org/10.1016/j.cgh.2023.01.019 PMid:36731591

Mishra P, Pandey CM, Singh U, Gupta A, Sahu C, Keshri A.: Descriptive statistics and normality tests for statistical data. Annals of cardiac anaesthesia. 2019 Jan 1;22(1):67-72. https://doi.org/10.4103/aca.ACA_157_18 PMid:30648682 PMCid:PMC6350423

Kishore K, Jaswal V.: Statistics Corner: Paired Groups. Journal of Postgraduate Medicine, Education and Research. 2023 May 31;57(2):90-3. https://doi.org/10.5005/jp-journals-10028-1626

Hill DJ, Heine RG, Cameron DJ, Cairo-Smith AG, Chow CW, Francis DE, Hosking CS.: Role of food protein intolerance in infants with persistent distress attributed to reflux esophagitis. The Journal of pediatrics. 2000 May 1;136(5):641-7. https://doi.org/10.1067/mpd.2000.104774 PMid:10802497

Lacono G, Carroccio A, Cavataio F, Montalto G, Kazmierska I, Lorello D, Soresi M, Notarbartolo A.: Gastroesophageal reflux and cow's milk allergy in infants: a prospective study. Journal of allergy and clinical immunology. 1996 Mar 1;97(3):822-7. https://doi.org/10.1016/S0091-6749(96)80160-6 PMid:8613639

Farahmand F, Najafi M, Ataee P, Modarresi V, Shahraki T, Rezaei N.: Cow's milk allergy among children with gastroesophageal reflux disease. Gut and liver. 2011 Sep;5(3):298. https://doi.org/10.5009/gnl.2011.5.3.298 PMid:21927657 PMCid:PMC3166669

Husby S.: Food allergy as seen by a paediatric gastroenterologist. Journal of Pediatric Gastroenterology and Nutrition. 2008 Nov;47:S49-52. https://doi.org/10.1097/01.mpg.0000338813.97803.16

Isolauri E, Sütas Y, Salo MK, Isosomppi R, Kaila M.: Elimination diet in cow's milk allergy: risk for impaired growth in young children. The Journal of pediatrics. 1998 Jun 1;132(6):1004-9. https://doi.org/10.1016/S0022-3476(98)70399-3 PMid:9627594

Downloads

Published

2024-12-15

How to Cite

1.
El-Asheer O, Abdelsattar HA, Mahmoud AA, Aly HM, El-Amir MB. Impact of the Maternal and/or Infant Elimination Diet on Infants with Gastroesophageal Reflux Disease. Open Access Maced J Med Sci [Internet]. 2024 Dec. 15 [cited 2026 Apr. 22];12(4):558-61. Available from: https://oamjms.eu/index.php/mjms/article/view/11967