Effect of Ablation of Superficial Vein Incompetence in Patient with Symptomatic Chronic Peripheral Arterial Disease - Case Report

Authors

  • Sasko Nikolov Faculty of Medical Sciences, Goce Delchev University, Shtip, Republic of North Macedonia; Department of Cardiology, Clinical Hospital, Shtip, Republic of North Macedonia https://orcid.org/0009-0006-5666-7754
  • Milka Zdravkovska Faculty of Medical Sciences, Goce Delchev University, Shtip, Republic of North Macedonia
  • Gordana Kamceva-Mihailova Faculty of Medical Sciences, Goce Delchev University, Shtip, Republic of North Macedonia; Department of Cardiology, Clinical Hospital, Shtip, Republic of North Macedonia

DOI:

https://doi.org/10.3889/oamjms.2025.11991

Keywords:

Peripheral arterial disease, Superficial vein incompetence, Cyanoacrylate ablation, CT scan angiography, Doppler ultrasound

Abstract

BACKGROUND: The importance and relation of superficial vein incompetence (SVI) in patients with peripheral arterial disease (PAD) were all surgical and PTA interventions are used for saving extremities. In order to protect patients from amputation we have provide a case where with ablation of the SVI we provide better peripheral arterial circulation with forming a completely new arterial collateral network for revascularization of the lower extremities.

CASE REPORT: This case is about a patient diagnosed with PAD with previous PTA/stent interventions and all stents are occluded now it’s in critical limb ischemia. It was made of a medical Consilium with vascular surgeon and interventionalist and there was no other option of treatment of arterial system of lower limb. We have done Doppler ultrasound of arterial and vein system of lower limbs and CT scan angiography.

CONCLUSION: In our patient with PAD and Buerger’s disease with SVI, with ablation of SVI we provide better arterial revascularization of the arterial system of lower limb and new arterial collaterals were formed sufficient to provide enough arterial blood supply to the lower limb. After ablation of SVI we had a much better objective and subjective symptoms.

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References

Jones WS, Patel MR, Dai D, Vemulapalli S, Subherwal S, Stafford J, Peterson ED. High mortality risks after major lower extremity amputation in Medicare patients with peripheral artery disease. Am Heart J. 2013;165:809-15, 815.e1. https://doi.org/10.1016/j.ahj.2012.12.002 PMid:23622919 DOI: https://doi.org/10.1016/j.ahj.2012.12.002

Ohman EM, Bhatt DL, Steg PG, Goto S, Hirsch AT, Liau CS, Mas JL, Richard AJ, Röther J, Wilson PW; REACH Registry Investigators. The Reduction of Atherothrombosis for Continued Health (REACH) registry: an international, prospective, observational investigation in subjects at risk for atherothrombotic events-study design. Am Heart J. 2006;151:786.e1-786.10. https://doi.org/10.1016/j.ahj.2005.11.004 PMid:16569533 DOI: https://doi.org/10.1016/j.ahj.2005.11.004

Fowkes FGR, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, Folsom AR, Hirsch AT, Dramaix M, deBacker G, et al; Ankle Brachial Index Collaboration. Ankle brachial index combined with framingham risk score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008;300:197-208. https://doi.org/10.1001/jama.300.2.197 PMid:18612117 PMCid:PMC2932628 DOI: https://doi.org/10.1001/jama.300.2.197

Murabito JM, Evans JC, Larson MG, Nieto K, Levy D, Wilson PW; Framingham Study. The ankle-brachial index in the elderly and risk of stroke, coronary disease, and death: the Framingham Study. Arch Intern Med. 2003;163:1939-1942. https://doi.org/10.1001/archinte.163.16.1939 PMid:12963567 DOI: https://doi.org/10.1001/archinte.163.16.1939

Cotter G, Cannon CP, McCabe CH, Michowitz Y, Kaluski E, Charlesworth A, Milo O, Bentley J, Blatt A, Krakover R, et al; OPUS-TIMI 16 Investigators. Prior peripheral arterial disease and cerebrovascular disease are independent predictors of adverse outcome in patients with acute coronary syndromes: are we doing enough? Results from the Orbofiban in Patients With Unstable Coronary Syndromes-Thrombolysis in Myocardial Infarction (OPUS-TIMI) 16 study. Am Heart J. 2003;145:622-627. https://doi.org/10.1067/mhj.2003.6 PMid:12679757 DOI: https://doi.org/10.1067/mhj.2003.6

Golomb BA, Dang TT, Criqui MH. Peripheral arterial disease: morbidity and mortality implications. Circulation. 2006;114:688-699. https://doi.org/10.1161/CIRCULATIONAHA.105.593442 PMid:16908785 DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.593442

Marrett E, DiBonaventura Md, Zhang Q. Burden of peripheral arterial disease in Europe and the United States: a patient survey. Health Qual Life Outcomes. 2013;11:175. https://doi.org/10.1186/1477-7525-11-175 PMid:24148832 PMCid:PMC3854518 DOI: https://doi.org/10.1186/1477-7525-11-175

Fowkes FG, Rudan D, Rudan I, Aboyans V, Denenberg JO, McDermott MM, Norman PE, Sampson UK, Williams LJ, Mensah GA, et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet. 2013;382:1329-1340. https://doi.org/10.1016/S0140-6736(13)61249-0 PMid:23915883 DOI: https://doi.org/10.1016/S0140-6736(13)61249-0

Corcos L, Procacci T, Peruzzi G, Dini M, De Anna D. Sapheno-femoral valves. Histopathological observations and diagnostic approach before surgery. Dermatologic Surgery 1996;22(10):873-80. https://doi.org/10.1111/j.1524-4725.1996.tb00591.x PMid:9246171 DOI: https://doi.org/10.1111/j.1524-4725.1996.tb00591.x

Corcos L, De Anna D, Dini M, Macchi C, Ferrari PA, Dini S. Proximal long saphenous vein valves in primary venous insufficiency. Journal des Maladies Vasculaires 2000;25(1):27-36.

Trendelenburg F. Via the connection of the great saphenous vein to the lower leg varices [Uber die tunderbindung der vena saphena magna bie unterschenkel varicen]. Beitrage zur Klinischen Chirurgie 1890;7:195.

Jones GT, Grant MW, Thomson IA, Hill BG, Van Rij AM. Characterization of a porcine model of chronic superficial varicose veins. Journal of Vascular Surgery 2009;49(6):1554-61 https://doi.org/10.1016/j.jvs.2009.01.070 PMid:19497519 DOI: https://doi.org/10.1016/j.jvs.2009.01.070

Labropoulos N, Leon L, Kwon S, Tassiopoulos A, Gonzalez-Fajardo JA, Kang SS, et al. Study of the venous reflux progression. Journal of Vascular Surgery 2005;41(2):291-5. https://doi.org/10.1016/j.jvs.2004.11.014 PMid:15768012 DOI: https://doi.org/10.1016/j.jvs.2004.11.014

Pascarella L, Schmid-Schonbein GW, Bergan J. An animal model of venous hypertension: the role of inflammation in venous valve failure. Journal of Vascular Surgery 2005;41(2):303-11. https://doi.org/10.1016/j.jvs.2004.10.038 PMid:15768014 DOI: https://doi.org/10.1016/j.jvs.2004.10.038

Takase S, Pascarella L, Bergan JJ, Schmid-Schonbein GW. Hypertension-induced venous valve remodeling. Journal of Vascular Surgery 2004;39(6):1329-34. https://doi.org/10.1016/j.jvs.2004.02.044 PMid:15192576 DOI: https://doi.org/10.1016/j.jvs.2004.02.044

Carpentier PH, Cornu-Thénard A, Uhl JF, Partsch H, Antignani PL. Appraisal of the information content of the C classes of CEAP clinical classification of chronic venous disorders; a multi centre evaluation. Journal of Vascular Surgery 2003;37(4):827-33. https://doi.org/10.1067/mva.2003.147 PMid:12663984 DOI: https://doi.org/10.1067/mva.2003.147

National Institute for Health and Care Excellence (NICE). Ultrasound-guided foam sclerotherapy for varicose veins. Interventional procedures guidance, IPG440; February 2013. nice.org.uk/guidance/ipg440 (accessed 18 January 2019).

Labropoulos N, Leon M, Nicolaides AN, Giannoukas AD, Volteas N, Chan P. Superficial venous insufficiency: correlation of anatomic extent of reflux with clinical symptoms and signs. Journal of Vascular Surgery 1994;20(6):953-8. https://doi.org/10.1016/0741-5214(94)90233-X PMid:7990191 DOI: https://doi.org/10.1016/0741-5214(94)90233-X

Rabe E, Pannier F, Ko A, Berboth G, Hoffmann B, Hertel S. Incidence of varicose veins, chronic venous insufficiency, and progression of the disease in the Bonn Vein Study II. Journal of Vascular Surgery 2010;51(3):P791. https://doi.org/10.1016/j.jvs.2009.11.014 DOI: https://doi.org/10.1016/j.jvs.2009.11.014

Sarin S, Scurr JH, Coleridge Smith PD. Assessment of stripping the long saphenous vein in treatment of primary varicose veins. British Journal of Surgery 1992;79(9):889-93. https://doi.org/10.1002/bjs.1800790911 PMid:1422747 DOI: https://doi.org/10.1002/bjs.1800790911

Carradice D, Mekako A, Hatfield J, Chetter I. Recurrent varicose veins are more common following surgery than EVLT - results of a randomised controlled trial. The Vascular Society of Great Britain and Ireland Yearbook 2009:86.

Carradice D, Mekako AI, Hatfield J, Chetter IC. A randomised trial of EVLT vs surgery for varicose veins. The Vascular Society of Great Britain and Ireland Yearbook 2008:91. https://doi.org/10.1002/bjs.6542 DOI: https://doi.org/10.1002/bjs.6542

Carradice D, Mekako AI, Mazari FA, Samuel N, Hatfield J, Chetter IC. Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. British Journal of Surgery 2011;98(8):1117-23. [PubMed] [Google Scholar] https://doi.org/10.1002/bjs.7615 PMid:21638277 DOI: https://doi.org/10.1002/bjs.7615

Carradice D, Mekako AI, Mazari FA, Samuel N, Hatfield J, Chetter IC. Randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. British Journal of Surgery 2011;98(4):501-10. https://doi.org/10.1002/bjs.7394 PMid:21283981 DOI: https://doi.org/10.1002/bjs.7394

Carradice D, Wallace T, Samuel N, Gohil R, Chetter I. A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency. Vascular Society of Great Britain and Ireland Yearbook 2012:38.

Wallace T, El-Sheikha J, Nandhra S, Leung C, Mohamed A, Harwood A, et al. Long-term outcomes of endovenous laser ablation and conventional surgery for great saphenous varicose veins. British Journal of surgery 2018;105:1759-67. https://doi.org/10.1002/bjs.10961 PMid:30132797 DOI: https://doi.org/10.1002/bjs.10961

Critchley G, Handa A, Maw A, Harvey A, Harvey MR, Corbett CR. Complications of varicose vein surgery. Annals of the Royal College of Surgeons of England 1997;79(2):105-10.

Joh JH, Kim WS, Jung IM, Park KH, Lee T, Kang JM, et al. Consensus for the treatment of varicose vein with radiofrequency ablation. Vascular Specialist International 2014;30(4):105-12. https://doi.org/10.5758/vsi.2014.30.4.105 PMid:26217628 PMCid:PMC4480318 DOI: https://doi.org/10.5758/vsi.2014.30.4.105

National Institute for Health and Care Excellence (NICE). Varicose veins in the legs: the diagnosis and management of varicose veins. Clinical guideline CG168; July 2013. nice.org.uk/guidance/CG168 (accessed 14 July 2014).

Devereux N, Recke AL, Westermann L, Recke A, Kahle B. Catheter-directed foam sclerotherapy of great saphenous veins in combination with pre-treatment reduction of the diameter employing the principals of perivenous tumescent local anesthesia. European Journal of Vascular and Endovascular Surgery 2014;47:187-195. https://doi.org/10.1016/j.ejvs.2013.10.017 PMid:24268395 DOI: https://doi.org/10.1016/j.ejvs.2013.10.017

Proebstle TM, Alm J, Dimitri S, Rasmussen L, Whiteley M, Lawson J, et al. The European multicenter cohort study on cyanoacrylate embolization of refluxing great saphenous veins. Journal of Vascular Surgery 2015;3(1):2-7. https://doi.org/10.1016/j.jvsv.2014.09.001 PMid:26993674 DOI: https://doi.org/10.1016/j.jvsv.2014.09.001

Leung C, Carradice D, Wallace T, Chetter IC. Endovenous laser ablation versus mechanochemical ablation with ClariVein® in the management of superficial venous insufficiency (LAMA trial): study protocol for a randomised controlled trial. Trials 2016;17(1):421. https://doi.org/10.1186/s13063-016-1548-1 PMid:27552990 PMCid:PMC4995808 DOI: https://doi.org/10.1186/s13063-016-1548-1

Shepherd AC, Gohel MS, Brown LC, Metcalfe MJ, Hamish M, Davies AH. Randomized clinical trial of VNUS ClosureFAST radiofrequency ablation versus laser for varicose veins. British Journal of Surgery 2010;97(6):810-8. https://doi.org/10.1002/bjs.7091 PMid:20473992 DOI: https://doi.org/10.1002/bjs.7091

Tang TY, Kam JW, Gaunt ME. ClariVein® - early results from a large single-centre series of mechanochemical endovenous ablation for varicose veins. Phlebology 2017;32(1):6-12. https://doi.org/10.1177/0268355516630154 PMid:26908638 PMCid:PMC5302071 DOI: https://doi.org/10.1177/0268355516630154

Morrison N, Gibson K, McEnroe S, Goldman M, King T, Weiss R, et al. Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose). Journal of Vascular Surgery 2015;61(4):985-94. https://doi.org/10.1016/j.jvs.2014.11.071 PMid:25650040 DOI: https://doi.org/10.1016/j.jvs.2014.11.071

Almeida JI, Javier JJ, Mackay E, Bautista C, Proebstle TM. First human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. J Vasc Surg Venous Lymphat Disord 2013;1:174-80. https://doi.org/10.1016/j.jvsv.2012.09.010 PMid:26992340 DOI: https://doi.org/10.1016/j.jvsv.2012.09.010

Gloviczki, P. Handbook of venous and lymphatic disorders: guidelines of the American Venous Forum. 4th ed. Boca Raton, Fla: CRC Press; 2017. https://doi.org/10.1201/9781315382449 DOI: https://doi.org/10.1201/9781315382449

Al Shakarchi J, Wall M, Newman J, Pathak R, Rehman A, Garnham A, et al. The role of compression after endovenous ablation of varicose veins. J Vasc Surg Venous Lymphat Disord 2018;6:546-50. https://doi.org/10.1016/j.jvsv.2018.01.021 PMid:29680 DOI: https://doi.org/10.1016/j.jvsv.2018.01.021

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Published

2025-03-15

How to Cite

1.
Nikolov S, Zdravkovska M, Kamceva-Mihailova G. Effect of Ablation of Superficial Vein Incompetence in Patient with Symptomatic Chronic Peripheral Arterial Disease - Case Report. Open Access Maced J Med Sci [Internet]. 2025 Mar. 15 [cited 2026 May 27];13(1):31-7. Available from: https://oamjms.eu/index.php/mjms/article/view/11991

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