IgG-Mediated Food Intolerance in a Patient with Allergic Symptoms, Acne and Obesity - Effect of Elimination Diet
DOI:
https://doi.org/10.3889/oamjms.2024.12010Keywords:
food allergy, IgG, food intoleranceAbstract
BACKGROUND: Although the association of food-specific IgG with the development and progression of specific diseases has been shown by many studies, strong correlations are still under question. Are these antibodies a normal immune response to foods, or is the pathogenetic mechanism triggered in another way? Why do elimination diets improve, in many studies, different diseases at different ages?
CASE PRESENTATION: We will present the case of a patient who experienced significant improvement in allergic symptoms and reduced body weight by implementing an elimination diet. Type III hypersensitivity reactions are associated with IgG antibodies. They are considered to be normal reactions to food antigens. They are absorbed into the bloodstream in small amounts. However, immediately after a meal, antibodies and food antigen complexes bound to specific IgG circulate in the serum, rapidly cleared by a healthy immune system, specifically the reticuloendothelial system. If large amounts of antibodies are produced and immune complexes are deposited in the blood vessels of various organs and organ systems, various manifestations may occur.
CONCLUSION: This is a new field of medicine. Further research, better-standardized tests, and much more extensive studies are needed to prove how to utilize the IgG antibody-based elimination diet properly.
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References
Abbas, A. K., Lichtman, A. H., & Pillai, S. Cellular and molecular immunology (10th ed.). Philadelphia: Saunders Elsevier. 2022.
Rich R, Fleisher T, Schroeder Jr. H, Weyand C, Corry D, Puck J. Clinical Immunology (6th ed.). Philadelphia: Saunders Elsevier. 2023.
Bonači-Nikolić B, Poremećaji imunskog odgovora, u poglavlju VII Alergologija i klinička imunologija, Interna medicina, Data Medika 2021.
Jutel M, et al. Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper. Allergy. 2023;78(11):2851-2874. https://doi.org/10.1111/all.15889 PMid:37814905 DOI: https://doi.org/10.1111/all.15889
Arzola-Martínez L, Ptaschinski C, Lukacs NW. Trained in innate immunity, epigenetics, and food allergy. Front Allergy. 2023;4:1105588. https://doi.org/10.3389/falgy.2023.1105588 PMid:37304168 PMCid:PMC10251748 DOI: https://doi.org/10.3389/falgy.2023.1105588
Citi S, Fromm M, Furuse M, González-Mariscal L, Nusrat A, Tsukita S, Turner JR. A short guide to the tight junction. J Cell Sci. 2024;137(9):jcs261776. https://doi.org/10.1242/jcs.261776 PMid:38712627 PMCid:PMC11128289 DOI: https://doi.org/10.1242/jcs.261776
Kanagaratham C, El Ansari YS, Lewis OL, Oettgen HC. IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy. Front Immunol. 2020;11:603050. https://doi.org/10.3389/fimmu.2020.603050 PMid:33362785 PMCid:PMC7759531 DOI: https://doi.org/10.3389/fimmu.2020.603050
Burton OT, Tamayo JM, Stranks AJ, Koleoglou KJ, Oettgen HC. Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance. J Allergy Clin Immunol. 2018;141(1):189-201. https://doi.org/10.1016/j.jaci.2017.03.045 PMid:28479335 PMCid:PMC5671359 DOI: https://doi.org/10.1016/j.jaci.2017.03.045
Dawson KP, Ford RP, Mogridge N. Childhood asthma: What do parents add or avoid in theirchildren'ss diets? N Z Med J.1990;103:239 40.
Kumar R; Singh M; Gupta N; Kumar M; Bisht I; Gaur SN. Prevalence of food intolerance in bronchial asthma in India.Indian Journal of Allergy, Asthma and Immunology.2013;27(2):121-128. https://doi.org/10.4103/0972-6691.124394 DOI: https://doi.org/10.4103/0972-6691.124394
Vance GHS, et al. Ovalbumin-specific immunoglobulin G and subclass responses through the first 5 years of life in relation to duration of egg sensitization and the development of asthma. Clin Exp Allergy.2004;34:1542-1549. https://doi.org/10.1111/j.1365-2222.2004.02058.x PMid:15479268 DOI: https://doi.org/10.1111/j.1365-2222.2004.02058.x
Virdee K, et al. Food-specific IgG Antibody-guided elimination diets followed by resolution of asthma symptoms and reduction in pharmacological interventions in two patients: A case report. Glob Adv Health Med. 2005; 4:62-66. https://doi.org/10.7453/gahmj.2014.068 PMid:25694853 PMCid:PMC4311561 DOI: https://doi.org/10.7453/gahmj.2014.068
Wilders-Truschnig M, Mangge H, Lieners C, Gruber H, Mayer C, März W. IgG antibodies against food antigens are correlated with inflammation and intima media thickness in obese juveniles. Exp Clin Endocrinol Diabetes. 2008;116(4):241-5. https://doi.org/10.1055/s-2007-993165 PMid:18072008 DOI: https://doi.org/10.1055/s-2007-993165
Koshak EA, Atwah AF, Ahmad HMY. IgG food hypersensitivity: A potential hidden precipitant for chronic spontaneous urticaria A case report. Allergol Immunopathol (Madr). 2023;51(4):148-150. https://doi.org/10.15586/aei.v51i4.889 PMid:37422791 DOI: https://doi.org/10.15586/aei.v51i4.889
Shakoor Z, Al Faifi A, Al Amro B, Al Tawil LN, Al Ohaly RY. Prevalence of IgG-mediated food intolerance among patients with allergic symptoms. Ann Saudi Med. 2016;36(6):386-390. https://doi.org/10.5144/0256-4947.2016.386 PMid:27920409 PMCid:PMC6074204 DOI: https://doi.org/10.5144/0256-4947.2016.386
Antico A, Pagani M, Vescovi P, Bonadonna P, Senna G. Foodspecific IgG4 lack diagnostic value in adult patients with chronic urticaria and other suspected allergy skin symptoms. Int Arch Allergy Immunol. 2011;155(1):52-56. https://doi.org/10.1159/000318736 PMid:21109748 DOI: https://doi.org/10.1159/000318736
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Copyright (c) 2024 Marija Andjelković, Aleksandra Vojvodić, Nenad Dikić (Author)
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