Presepsin Levels in Emergency Patients with Bacterial and Viral Infection
DOI:
https://doi.org/10.3889/oamjms.2020.3204Keywords:
Sepsis, Bacterial infection, Viral infection, Emergency department, Emergency medicineAbstract
BACKGROUND: Sepsis is a major problem with a high mortality rate, and emergency rooms are the first service point at which sepsis patients are treated. Blood presepsin levels are used as a tool to identify patients who may suffer from sepsis caused by bacterial infection, necessitating immediate antibiotic treatment.AIM: The aim of the study was to evaluate presepsin levels in patients with bacterial and viral infections in the emergency department.
METHODS: This was a prospective study consisting of 88 patients over 18 years of age who visited the Srinagarind Hospital emergency room and fulfilled one or more criteria for systemic inflammatory response syndrome. Presepsin levels in the leftover blood specimens were tested.
RESULTS: In the bacterial infection group, 63.6% of the patients were male, and the mean age was 43.7 ± 10.5 years. Mean presepsin levels were 2904.73, pg/ml in the bacterial infection group and 204.88 pg/ml in the viral infection group.
CONCLUSION: Presepsin levels in the bacterial infection group were significantly higher than in the viral infection group, in which they were below the standard cutoff point.
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References
Angus DC, Van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369(9):840-51. https://doi.org/10.1056/nejmra1208623 PMid:23984731
Angkasekwinai N, Rattanaumpawan P, Thamlikitkul V. Epidemiology of sepsis in Siriraj Hospital 2007. J Med Assoc Thai. 2009;92(Suppl 2):S68-78. PMid:19562989
Filbin MR, Arias SA, Camargo CA, Barche A, Pallin DJ. Sepsis visits and antibiotic utilization in U.S. emergency departments. Crit Care Med. 2014;42(3):528-35. https://doi.org/10.1097/ccm.0000000000000037 PMid:24201179
Kibe S, Adams K, Barlow G. Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother. 2011;66(Suppl 2):33-40. PMid:21398306
Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: A systematic review and meta-analysis. Lancet Infect Dis. 2013;13(5):426-35. https://doi.org/10.1016/s1473-3099(12)70323-7 PMid: 23375419
Sridharan P, Chamberlain RS. The efficacy of procalcitonin as a biomarker in the management of sepsis: Slaying dragons or tilting at windmills? Surg Infect. 2013;14(6):489-511. https://doi.org/10.1089/sur.2012.028 PMid: 24274059
Lu B, Zhang Y, Li C, Liu C, Yao Y, Su M, et al. The utility of presepsin in diagnosis and risk stratification for the emergency patients with sepsis. Am J Emerg Med. 2018;36(8):1341-5. https://doi.org/10.1016/j.ajem.2017.12.038 PMid: 29276032
Shirakawa K, Naitou K, Hirose J, Takahashi T, Furusako S. Presepsin (sCD14-ST): Development and evaluation of one-step ELISA with a new standard that is similar to the form of presepsin in septic patients. Clin Chem Lab Med. 2011;49(5):937-9. https://doi.org/10.1515/cclm.2011.145 PMid: 21345045
Shozushima T, Takahashi G, Matsumoto N, Kojika M, Okamura Y, Endo S. Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemother. 2011;17(6):764-9. https://doi.org/10.1007/s10156-011-0254-x PMid: 21560033
Okamura Y, Yokoi H. Development of a point-of-care assay system for measurement of presepsin (sCD14-ST). Clin Chim Acta. 2011;412(23-24):2157-61. https://doi.org/10.1016/j.cca.2011.07.024 PMid: 21839732
Sugie Y, Igami K, Shoji K, Arai N, Tazaki Y, Kouta H, et al. Performance evaluation of the new rapid fertility assays in whole blood and plasma on PATHFAST. Clin Lab. 2011;57(1-2):99-106. PMid:21391473
Endo S, Suzuki Y, Takahashi G, Shozushima T, Ishikura H, Murai A, et al. Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study. J Infect Chemother. 2012;18:891-7. https://doi.org/10.1007/s10156-012-0435-2 PMid: 21391473
Yaegashi Y, Shirakawa K, Sato N, Suzuki Y, Kojika M, Imai S, et al. Evaluation of anewly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemother. 2005;11(5):234-8. https://doi.org/10.1007/s10156-005-0400-4 PMid: 16258819
Godnic M, Stubljar D, Skvarc M, Jukic T. Diagnostic and prognostic value of sCD14- ST–presepsin for patients admitted to hospital intensive care unit (ICU). Wien Klin Wochenschr. 2015;127(13-14):521-7. https://doi.org/10.1007/s00508-015-0793-8 PMid: 25854904
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Copyright (c) 2020 Korakot Apiratwarakul, Nipa Srimookda, Pariwat Phungoen , Kamonwon Ienghong, Somsak Tiamkao, Vajarabhongsa Bhudhisawasdi (Author)
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