Evaluation  of  Magnetic  Parameters  and  Kinetics  of  the  Magnetic  Nanoparticles in High Magnetic Fields and its Potential Applications

Mark Christopher Arokiaraj; Aleksandr Liubimtcev

doi:10.3889/oamjms.2020.3256

Authors

Mark Christopher Arokiaraj Department of Cardiology, Pondicherry Institute of Medical Sciences, Pondicherry, India
Aleksandr Liubimtcev Quickfield Support Team, Tera Analysis Ltd., Svendborg, Denmark

DOI:

https://doi.org/10.3889/oamjms.2020.3256

Keywords:

Magnetic nanoparticles, High magnetic fields, Electromagnetic finite element analysis, Angiogenesis, Tissue engineering, Halbach array

Abstract

BACKGROUND: Multifunctional nanoparticles are known for their wide range of biomedical applications. Controlling the magnetic properties of these nanoparticles is imperative for various applications, including therapeutic angiogenesis. AIM: The study was performed to evaluate the magnetic properties and their control mechanisms by the external magnetic field.

METHODS: A100 nm magnetic nanoparticle was placed in the magnetic field, and parametrically, the magnet field strength and distance were evaluated. Various models of magnetic strength and disposition were evaluated. Magnetic flux density, force/weight, and magnetic gradient strength were the parameters evaluated in the electromagnetic computational software.

RESULTS: The seven-coil method with three centrally placed coils as Halbach array, and each coil with a flux density of 7 Tesla, and with a coil dimension of 20 cm Ã— 20 cm (square model) of each coil showed a good magnetic strength and force/weight parameters in a distance of 15 cm from the centrally placed coil. The particles were then evaluated for their motion characteristics in saline. It showed good displacement and acceleration properties. After that, the particles were theoretically assessed in a similar mathematical model after parametrically correcting the drag force. After the application of high drag forces, the particles showed adequate motion characteristics. When the particle size was reduced further, the motion characteristics were preserved even with high drag forces.

CONCLUSION: There is potential for a novel method of controlling multifunctional magnetic nanoparticles using high magnetic fields. Further studies are required to evaluate the motion characteristics of these particles in vivo and in vitro.

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