Duration and Mortality Characteristics of Patients with Cerebral Tumors Treated in the Intensive Care Unit of Sanglah General Hospital from January to December 2017

Authors

  • Wayan Widyantara Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • I Gusti Agung Gede Ariswanda Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • Kadek Agus Sudha Naryana Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • Ni Nyoman Ayu Trisnadewi Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • Ida Bagus Kusuma Putra Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • Ni Putu Witari Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • IGN Purna Putra Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • I Putu Eka Widyadharma Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia
  • Ketut Sinardja Department of Anesthesiology and Reanimation, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.3297

Keywords:

Brain tumor, Surgery, Intensive care, Mortality

Abstract

BACKGROUND: The incidence and survival rates of cerebral tumor patients are increasing, along with advances in medical technology. Severe complications, such as multiorgan failure in patients, cause the need for intensive care to improve. The effectiveness of intensive care in tumor patients is still controversial, considering that patients included in low and vulnerable performance status. Patients with cerebral tumors also require intensive care either before or after effective action. The controversy of economic and ethical issues still places aggressive action in intensive care on oncology patients. It is necessary to identify and know the characteristics of tumor patients that are useful in intensive management.

AIM: The purpose of this study was to determine the demographic characteristics, length of stay, complications, and mortality rates of cerebral tumor patients undergoing intensive care at Sanglah Hospital Denpasar, the period January–December 2017.

METHODS: This study is a cross-sectional descriptive where all sample data collection is secondarily based on existing medical records. The sample population in this study were cerebral tumor patients treated in the intensive care ward Sanglah period January–December 2017 who met the inclusion criteria.

RESULTS: In the study, it found that 54 patients with the highest number of cerebral tumors treated in the intense sex with women (64.85%) and middle-aged adults (41–60 years) were 31 patients (57.4%). Most diagnoses of cerebral tumors were 39 non-glioma tumors (72.2%) followed by glioma tumors (20.4%) and tumor metastases (7.4%). Non-glioma tumors noted were meningiomas of around 48.1%, followed by glioblastoma multiforme tumors of 9.3%, tumors at the cerebellopontine angle and tumor metastases of 7.4%, respectively. All patients were treated intensively after receiving surgical therapy with a Karnofsky 50 score of about 29 patients (53.7%). All patients came out alive, and there were no recorded complications during treatment with the maximum length of stay of patients in the intensive care unit for up to 3 days by 45 patients (83.3%).

CONCLUSION: The most brain tumor cases are meningioma, which occurred in women, middle-aged adults with no mortality and complications within 3 days during treatment intensive care.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

Author Biography

I Putu Eka Widyadharma, Department of Neurology, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia

Department of Neurology, Udayana University, Bali, Indonesia

References

Biskup E, Cai F, Vetter M, Marsch S. Oncological patients in the intensive care unit: Prognosis, decision-making, therapies, and end-of-life care. Swiss Med Wkly. 2017;147(3132):w14481. https://doi.org/10.4414/smw.2017.14558 PMid:28804862

Azoulay E, Soares M, Darmon M, Benoit D, Pastores S, Afessa B. Intensive care of the cancer patient: Recent achievements and remaining challenges. Ann Intensive Care. 2011;1(1):5. https:// doi.org/10.1186/2110-5820-1-5 PMid:21906331

Tabouret E, Boucard C, Devillier R, Barrie M, Boussen S, Autran D, et al. Neuro-oncological patients admitted in the intensive-care unit: Predictive factors and functional outcome. J Neurooncol. 2016;127(1):111-7. https://doi.org/10.1007/ s11060-015-2015-7 PMid:26608523

Lonjaret L, Guyonnet M, Berard E, Vironneau M, Peres F, Sacrista S, et al. Postoperative complications after craniotomy for brain tumor surgery. Anaesth Crit Care Pain Med. 2017;36(4):213-8. https://doi.org/10.1016/j.accpm.2016.06.012 PMid:27717899

Oemiati R, Rahajeng E, Kristanto AY. Prevalensi tumour dan beberapa faktor yang mempengaruhinya di Indonesia. Bul Penelit Kesehat. 2012;39(4):190-204.

Jazayeri SB, Rahimi-Movaghar V, Shokraneh F, Saadat S, Ramezani R. Epidemiology of primary CNS tumors in Iran: A systematic. Asian Pac J Cancer Prev. 2013;14(6):3979-85. https://doi.org/10.7314/apjcp.2013.14.6.3979 PMid:23886218

McKinley BP, Michalek AM, Fenstermaker RA, Plunkett RJ. The impact of age and gender on the incidence of glial tumors in New York state from 1976-1995. J Neurosurg. 2000;93(6):932- 9. https://doi.org/10.3171/jns.2000.93.6.0932 PMid:11117865

Warrington NM, Sun T, Luo J, McKinstry RC, Parkin PC, Ganzhorn S, et al. The cyclic AMP pathway is a sex-specific modifier of glioma risk in Type I neurofibromatosis patients. Cancer Res. 2015;75(1):16-21. https://doi.org/10.1158/0008- 5472.can-14-1891 PMid:25381154

Goldhoff P, Warrington NM, Limbrick DD, Hope A, Woerner BM, Jackson E, et al. Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res. 2008;14(23):7717-25. https://doi. org/10.1158/1078-0432.ccr-08-0827 PMid:19047098

Warrington NM, Gianino SM, Jackson E, Goldhoff P, Garbow JR, Piwnica-Worms D, et al. Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1. Cancer Res. 2010;70(14):5717-27. https:// doi.org/10.1158/0008-5472.can-09-3769 PMid:20551058

Yang L, Jackson E, Woerner BM, Perry A, Piwnica-Worms D, Rubin JB. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007;67(2):651- 8. https://doi.org/10.1158/0008-5472.can-06-2762 PMid:17234775

Bajenaru ML, Hernandez MR, Perry A, Zhu Y, Parada LF, Garbow JR, et al. Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res. 2003;63(24):8573-7. PMid:14695164

Jung KW, Park S, Shin A, Oh CM, Kong HJ, Jun JK, et al. Do female cancer patients display better survival rates compared with males? Analysis of the Korean national registry data, 2005- 2009. PLoS One. 2012;7(12):e52457. https://doi.org/10.1371/ journal.pone.0052457 PMid:23300677

McKinney PA. Brain tumors: Incidence, survival, and etiology. J Neurol Neurosurg Psychiatry. 2004;75 Suppl 2:ii12-7. https:// doi.org/10.1136/jnnp.2004.040741 PMid:15146034

Wiemels J, Wrensch M, Claus EB. Epidemiology and etiology of meningioma. J Neurooncol. 2010;99(3):307-14. https://doi. org/10.1007/s11060-010-0386-3 PMid:20821343

Wiratma AT. Buku Ajar Neurologi. Jakarta: Kedokteran Indonesia; 2017. p. 323-36.

Downloads

Published

2020-09-03

How to Cite

1.
Widyantara W, Ariswanda IGAG, Naryana KAS, Trisnadewi NNA, Putra IBK, Witari NP, Putra IP, Widyadharma IPE, Sinardja K. Duration and Mortality Characteristics of Patients with Cerebral Tumors Treated in the Intensive Care Unit of Sanglah General Hospital from January to December 2017. Open Access Maced J Med Sci [Internet]. 2020 Sep. 3 [cited 2024 Nov. 23];8(A):797-800. Available from: https://oamjms.eu/index.php/mjms/article/view/3297