The Effect of Salam Leaf (Syzygium polyanthum [Wight] Walp.) Extract on Inflammation in Rat Model of Acute Coronary Syndrome

Refli Hasan; Dharma Lindarto; Gontar Alamsyah Siregar; Zulfikri Mukhtar

doi:10.3889/oamjms.2020.3459

Authors

Refli Hasan Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, H. Adam Malik General Hospital, Medan, Indonesia
Dharma Lindarto Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, H. Adam Malik General Hospital, Medan, Indonesia
Gontar Alamsyah Siregar Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, H. Adam Malik General Hospital, Medan, Indonesia
Zulfikri Mukhtar Department of Cardiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.3459

Keywords:

Salam leaf, Regenerating islet-derived protein 3 β, C-reactive protein, Infarction

Abstract

AIM: The aim of the study was to determine the effect of Salam leaf extract on regenerating islet-derived protein 3 β (Reg3β) and C-reactive protein (CRP) in cardiomyocyte of rat model of ACS.

METHODS: Thirty-six male Wistar rats were divided into three groups: Negative control group, positive control group (ACS-induced group), and treatment group (ACS-induced group with Salam leaf administration). Macroscopic appearance and histopathology examination were done to ensure the occurrence of infarction. Reg3β and CRP levels were measured and compared between the positive control group and treatment group.

RESULTS: There were significantly lower Reg3β and CRP levels in the treatment group than in the positive control group from day 4 to day 14.

CONCLUSION: These data suggest that a Salam leaf extract can improve inflammation by decreasing Reg3β and CRP levels in rat model of ACS.

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