Antiaging Activity of Gel Preparation Containing Three Varieties of Passion Fruit Peel Ethanolic Extract

Nazliniwaty Nazliniwaty; Fathur Rahman Harun; Effendy De Lux Putra; Nerdy Nerdy

doi:10.3889/oamjms.2020.3462

Authors

Nazliniwaty Nazliniwaty Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sumatera Utara, Padang Bulan, Medan Baru, Medan, Sumatera Utara 20155, Indonesia
Fathur Rahman Harun Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Padang Bulan, Medan Baru, Medan, Sumatera Utara 20155, Indonesia
Effendy De Lux Putra Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Padang Bulan, Medan Baru, Medan, Sumatera Utara 20155, Indonesia
Nerdy Nerdy Department of Pharmacy, Faculty of Pharmacy, Institut Kesehatan Deli Husada Deli Tua, Deli Tua Timur, Deli Tua, Deli Serdang, Sumatera Utara, 20355, Indonesia http://orcid.org/0000-0002-1993-4415

DOI:

https://doi.org/10.3889/oamjms.2020.3462

Keywords:

Antiaging, Gel, Extract, Peel, Passion Fruit

Abstract

BACKGROUND: Antiaging cosmetics are cosmetics that can prevent or correct the signs of premature aging. Passion fruit (Passiflora sp.) peel is an agricultural waste contains polyphenol compounds and flavonoids which are a source of natural antioxidants to prevent premature aging. The passion fruit peel extract formulated into gel preparations which can increase the economic value of the passion fruit peel waste.

OBJECTIVE: The objective of the study was to test the antiaging activity of gel preparations containing ethanolic extracts of purple, red, and yellow passion fruit on experimental animal skins with several parameters (wrinkle, melanin, pore, moisture, and elasticity).

METHODS: Gel was made by adding passion fruit peel extract with several concentrations (0.05%, 0.10%, 0.15%, 0.20%, and 0.25%) in gel base. The blank used is a gel base without extracts. Measurement of wrinkle, black pigment (melanin), pore size, moisture content, and elasticity was performed using a skin analyzer. The use of gel is done 2 times a day for 28 days.

RESULTS: Gel with purple, red, and yellow passion fruit peel extract can be formulated into gel preparations. The higher concentration of passion fruit peel extract shows a higher antiaging activity. Gel preparations with purple, red, and yellow passion fruit peel extract, respectively, show the recovery of wrinkle 16.16%, 8.73%, and 6.49%; recovery of melanin 20.11%, 10.75%, and 8.06%; recovery of pore 18.78%, 10.15%, and 7.69%; recovery of moisture 32.74%, 17.70%, and 13.04%; and recovery of elasticity 30.08%, 16.13%, and 12.30%.

CONCLUSIONS: The highest antiaging activity was given by gel preparations containing purple passion fruit peel extract and the lowest antiaging activity was given by gel preparations with yellow passion fruit peel extracts.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Zhang S, Duan E. Fighting against skin aging: The way from bench to bedside. Cell Transplant. 2018;27(5):729-38. https://doi.org/10.1177/0963689717725755 PMid:29692196

Wong YS, Sia CH, Khoo HE, Ang YK, Chang SK, Yim HS. Influence of extraction conditions on antioxidant properties of passion fruit (Passiflora edulis) Peel. Acta Sci Pol Technol Aliment. 2014;13(3):257-65. https://doi.org/10.17306/j. afs.2014.3.4 PMid:24887941

Thokchom R, Mandal G. Production preference and importance of passion fruit (Passiflora edulis): A review. J Agric Eng Technol. 2017;4(1):27-30.

Vollmer DL, West VA, Lephart ED. Enhancing skin health: By oral administration of natural compounds and minerals with implications to the dermal microbiome. Int J Mol Sci. 2018;19(10):E3059. https://doi.org/10.3390/ijms19103059 PMid:30301271

Singh D, Sachan AK, Kumar S. Formulation and evaluation of topical gel delivery of lornoxicam. World J Pharm Pharm Sci. 2018;7(6):884-96.

Ahmad I, Mulia K, Yanuar A, Mun’im A. Metabolite profiling analysis of conventional and non-conventional extraction methods on secondary metabolite from Peperomia pellucida (L.) Kunth using UPLC-QToF-MS/MS system. J Young Pharm. 2018;10(2s):S40-4. https://doi.org/10.5530/jyp.2018.2s.8

Kurniawansyah IS, Sopyan I, Wardhana YW, Gunasekaran M. Formulation and evaluation of chloramphenicol hydrogel ophthalmic preparation. J Young Pharm. 2018;10(2):S73-8. https://doi.org/10.5530/jyp.2018.2s.14

Sumaiyah S, Leisyah BM. The effect of antioxidant of grapeseed oil as skin anti-aging in nanoemulsion and emulsion preparations. Rasayan J Chem. 2019;12(3):1185-94. https://doi. org/10.31788/rjc.2019.1235337

Kim HI, Jeong YU, Kim JH, Park YJ. 3, 5, 6, 7, 8, 3’, 4’-Heptamethoxyflavone, a citrus flavonoid, inhibits collagenase activity and induces Type I procollagen synthesis in HDFn cells. Int J Mol Sci. 2018;19(2):E620. https://doi.org/10.3390/ ijms19020620 PMid:29470423

Ginwala R, Bhavsar R, Chigbu DI, Jain P, Khan ZK. Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of apigenin. Antioxidants (Basel). 2019;8(2):E35. https://doi.org/10.3390/ antiox8020035 PMid:30764536

Stout R, Birch-Machin M. Mitochondria’s role in skin ageing. Biology (Basel). 2019;8(1):E29. https://doi.org/10.3390/ biology8020029 PMid:31083540

Choi W, Yin L, Smuda C, Batzer J, Hearing VJ, Kolbe L. Molecular and histological characterization of age spots. Exp Dermatol. 2017;26(3):242-8. https://doi.org/10.1111/exd.13203 PMid:27621222

Bino SD, Duval C, Bernerd F. Clinical and biological characterization of skin pigmentation diversity and its consequences on UV impact. Int J Mol Sci. 2018;19(9):E2668. https://doi.org/10.3390/ijms19092668 PMid:30205563

Webb AR, Kazantzidis A, Kift RC, Farrar MD, Wilkinson J, Rhodes LE. Colour counts: Sunlight and skin type as drivers of Vitamin D deficiency at UK latitudes. Nutrients. 2018;10(4):E457. https://doi.org/10.3390/nu10040457 PMid:29642423

Zolghadri S, Bahrami A, Khan MT, Munoz-Munoz J, Garcia- Molina F, Garcia-Canovas F, et al. A comprehensive review on tyrosinase inhibitors. J Enzyme Inhib Med Chem. 2019;34(1):279- 309. https://doi.org/10.1080/14756366.2018.1545767 PMid:30734608

Ifeanyi OE. A review on free radicals and antioxidants. Int J Curr Res Med Sci. 2018;4(2):123-33.

Rembiesa J, Ruzgas T, Engblom J, Holefors A. The impact of pollution on skin and proper efficacy testing for anti-pollution claims. Cosmetics. 2018;5(1):4-12. https://doi.org/10.3390/ cosmetics5010004

Campa M, Baron E. Anti-aging effects of select botanicals: Scientific evidence and current trends. Cosmetics. 2018;5(3):54- 68. https://doi.org/10.3390/cosmetics5030054

Petruk G, Giudice RD, Rigano MM, Monti DM. Antioxidants from plants protect against skin photoaging. Oxid Med Cell Longev. 2018;2018:1454936. https://doi.org/10.1155/2018/1454936 PMid:30174780

Lu F, Wang C. Zhao R, Du L, Fang Z, Guo X, Zhao Z. Review of stratum corneum impedance measurement in non-invasive penetration application. Biosensors (Basel). 2018;8(2):E31. https://doi.org/10.3390/bios8020031 PMid:29587456

Schagen SK, Zampeli VA, Makrantonaki E, Zouboulis CC. Discovering the link between nutrition and skin aging. Dermatoendocrinol. 2012;4(3):298-307. https://doi.org/10.4161/ derm.22876 PMid:23467449

Addor FA. Beyond photoaging: Additional factors involved in the process of skin aging. Clin Cosmet Investig Dermatol. 2018;11:437-43. https://doi.org/10.2147/ccid.s177448 PMid:30288075