Anti-Inflammatory Activity of Rhaphidophora pinnata (L.F) Schott Leaf Extract


  • Sumaiyah Sumaiyah Department of Pharmacy Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Masfria Masfria Department of Pharmacy Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Aminah Dalimunthe Department of Pharmacy Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia



Anti-inflammatory, Ethanol extract, Paw edema, Rhaphidophora pinnata leaf


BACKGROUND: Cancer growth is influenced by many factors and in general it is an interaction between gene factors and environmental factors, especially the microenvironment that exists around cancer. The inflammatory response plays a decisive role in various stages of cancer growth.

AIM: The aim of this study was to determine the anti-inflammatory activity of ethanol extract of Rhaphidophora pinnata leaves.

METHODS: R. pinnata leaf extract was obtained by percolation method using 96% ethanol as the solvent at room temperature. Anti-inflammatory activity was determined based on the paw edema method. Thirty male albino mice were treated orally with sodium carboxyl cellulose suspension (as negative control group), R. pinnata leaf extract (35, 70, 140, and 280 mg/kgBW), and diclofenac (as positive control group), 60 min before 0.2 mL 1% carrageenan injection. The paw thickness was measured using plethysmometer before injecting the carrageenan and after 1, 2, 3, 4, 5, and 6 h.

RESULTS: The subplantar injection of carrageenan caused a time-dependent paw edema in the mice. Oral administration of R. pinnata leaf extract inhibited paw swelling at 1, 2, 3 4, 5, and 6 h after carrageenan injection. R. pinnata leaf extracts doses of 35, 70, 140, and 280 mg/kgBW gave a percentage inhibition of 56.56%, 56.18%, 62.77%, and 49.30%, respectively. The effective dose of R. pinnata leaf extract as an anti-inflammatory was 140 mg/kgBW.

CONCLUSION: Ethanol extract of R. pinnata leaf has anti-inflammatory activity in male albino mice.


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How to Cite

Sumaiyah S, Masfria M, Dalimunthe A. Anti-Inflammatory Activity of Rhaphidophora pinnata (L.F) Schott Leaf Extract. Open Access Maced J Med Sci [Internet]. 2020 Aug. 20 [cited 2024 May 24];8(A):487-90. Available from:

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