The Relation of Gene Polymorphism Interferon Gamma+874 A/T and Schizophrenia Occurred in Batak Ethnicity
Keywords:Schizophrenia, gen, polymorphism, gamma interferon
BACKGROUND: Massive heritability occurs in schizophrenia. Gene identification which is defenceless against this disorder is difficult to be proven. The potential aspect of gen vulnerability in developing schizophrenic symptoms, for instance, is shown by several complex gene of tumor necrosis factor-alpha, interleukin (IL)-1, IL-6, and IL-10.
AIMS: The aim of the study was to investigate the relationship of gene polymorphism of interferon-gamma (IFN-Î³) +874 A/T and schizophrenia symptoms to Batakâ€™s schizophrenic patients.
METHODS: This study is a caseâ€“control study involved with 248 subjects from Prof. M. Ildrem Medan Hospital. The subjects were divided into two groups, the first group (124 subjects) was recruited as the case group, while the other 124 subjects were grouped as control cases with ages of 20â€“55 years of old. The case study group was hospitalized patients in the hospital, while the control group is those donors in the blood transfusion unit at Pirngadi General Hospital, Medan, Indonesia. IFN-Î³ +874 A/T gene polymorphism was examined by polymerase chain reaction-restriction fragment length polymorphism method.
RESULTS: Genotype AT frequencies from gen IFN-Î³ +874 A/T were found higher in case study than those from control groups, which were accounted for 43.5% and 41.1%, respectively, with p = 0.005, odds ratio (OR) = 2.83 95% confidence interval (CI) 1.36â€“5.86. The allele T was displayed higher in case group compared to control groups contributed for 46.0% and 33.5%, respectively, with p = 0.006, OR = 0.59 95% (CI) 0.41â€“0.85, (p = 0.006).
CONCLUSIONS: There was a relationship between gen IFN-Î³ +874 A/T and schizophrenia on Batak ethnicity with schizophrenic disorder. The genotype AT contributes for increasing schizoprenic risk up to 2.83 times.
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Kim HJ, Eom CY, Kwon J, Joo J, Lee S, Nah SS, et al. Roles of interferon-gamma and its target genes in schizophrenia: Proteomics-based reverse genetics from mouse to human. Proteomics. 2012;12(11):1815-29. https://doi.org/10.1002/pmic.201100184 PMid:22623148
Light G, Greenwood TA, Swerdlow NR, Calkins ME, Freedman R, Green MF, et al. Comparison of the heritability of schizophrenia and endophenotypes in the COGS-1 family study. Schizophr Bull. 2014;40(6):1404-11. PMid:24903414
Patel KR, Cherian J, Gohil K, Atkinson D. Schizophrenia: Overview and treatment options. P T. 2014;39(1):638-45. PMid:25210417
World Health Organization. Schizophrenia; 2015. Available: https://www.who.int/news-room/factsheets/detail/schizophrenia. [Last accessed on 2018 Jun 12].
Kanazawa T, Bousman CA, Liu C, Everall IP. Schizophrenia genetics in the genome-wide era: A review of Japanese studies. NPJ Schizophr. 2017;3(1):27. https://doi.org/10.1038/s41537-017-0028-2 PMid:28855529
Dai N. Investigation of Findings of Recent Schizophrenia Genome Wide Association and Linkage Studies in Indonesian Samples. Thesis School of Psychiatry and Clinical Neuroscience. Australia: The University of Western Australia; 2013. p. 1-200.
Paul-Samojedny M, Owczarek A, Suchanek R, Kowalczyk M, Fila-Danilow A, Borkowska P, et al. Association study of interferon gamma (IFN-Î³) +874T/A gene polymorphism in patients with paranoid schizophrenia. J Mol Neurosci 2011;43(3):309-15. https://doi.org/10.1007/s12031-010-9442-x PMid:20821074
Kontsek P, KontsekovÃ¡ E. Forty years of interferon. Acta Virol. 1997;41(6):349-53.
Tamandani DM, Najafi M, Mojahed A, Shahraki A. Analysis of IFN-Î³ (++874 A/T) and IL-10 (-1082 G/A) genes polymorphisms with risk of schizophrenia. J Cell Mol Res. 2014;6:64-8.
Pravica V, Asderakis A, Perrey C, Hajeer A, Sinnott PJ, Hutchinson IV. In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene. Eur J Immunogenet. 1999;26(1):1-3. https://doi.org/10.1046/j.1365-2370.1999.00122.x PMid:10068907
Jemli A, Eshili A, Trifa F, Mechri A, Zaafrane F, Gaha L, et al. Association of the IFN-Î³ (++874 A/T) genetic polymorphism with paranoid schizophrenia in tunisian population. Immunol Invest. 2017; 46(2):159-71. https://doi.org/10.1080/08820139.2016.1237523
Giegling I, Hosak L, MÃ¶ssner R, Serretti A, Bellivier F, Claes S, et al. Genetics of schizophrenia: A consensus paper of the WFSBP task force on genetics. World J Biol Psychiatry. 2017;18(7):492-505. https://doi.org/10.1080/15622975.2016.1268715
Machado EZ, Duarte FA. Localization of genes modulating the predisposition to schizophrenia: A revision. Genet Mol Biol. 2000;23(3):549-56. https://doi.org/10.1590/s1415-47572000000300009
Chen J, Cao F, Liu L, Wang L, Chen X. Genetic studies of schizophrenia: An update. Neurosci Bull. 2015;31(1):87-98. PMid:25652814
Voisey J, Swagell CD, Hughes IP, Lawford BR, Young RM, Morris CP. Analysis of HapMap tag-SNPs in dysbindin (DTNBP1) reveals evidence of consistent association with schizophrenia. Eur Psychiatry. 2010;25(6):314-9. https://doi.org/10.1016/j.eurpsy.2009.11.011 PMid:20615671
Shi J, Gershon ES, Liu C. Genetic associations with schizophrenia: Meta-analyses of 12 candidate genes. Schizophr Res 2008;104(1-3):96-107. https://doi.org/10.1016/j.schres.2008.06.016 PMid:18715757
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Philadelphia, PA: American Psychiatric Publishing; 2013. p. 33-40.
Zambon CF, Basso D, Navaglia F, Belluco C, Falda A, Fogar P, et al. Pro and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: Interactions influence outcome. Cytokine. 2005;29(4):141-52. https://doi.org/10.1016/j.cyto.2004.10.013 PMid:15652446
Karki R, Pandya D, Elston RC, Ferlini C. Defining â€œmutationâ€ and â€œpolymorphismâ€ in the era of personal genomics. BMC Med Genomics. 2015;8:37. https://doi.org/10.1186/s12920-015-0115-z PMid:26173390
Hu D, Ziv E. Confounding in genetic association studies and its solution. Pharmacogenomics Drug Discov Dev. 2008;448:31-9. PMid:18370229
Orgogozo V, Morizot B, Martin A. The differential view of genotype-phenotype relationships. Front Genet. 2015;6:179. https://doi.org/10.3389/fgene.2015.00179 PMid:26042146
Liao PY, Lee KH. From SNPs to functional polymorphism: The insight into biotechnology application. Biochem Eng J. 2010;49(2):149-58.
Peferoen L, Kipp M, van der Valk P, van Noort JM, Amor S. Oligodendrocyte-microglia cross-talk in the central nervous system. Immunology. 2014;141(3):302-13. https://doi.org/10.1111/imm.12163 PMid:23981039
Muller N, Weidinger E, Leitner B, Schwarz MJ. The role of inflammation and the immune system in schizophrenia. Neurobiol Schizophr. 2016; Front neurosci. 2015;9:372. https://doi.org/10.3389/fnins.2015.00372 PMid:26539073
Kim YS, Joh TH. Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinsonâ€™s disease. Exp Mol Med. 2006;38(4):333-47. https://doi.org/10.1038/emm.2006.40 PMid:16953112
Laskaris LE, Di Biase MA, Everall I, Chana G, Christopoulos A, Skafidas E, et al. Microglial activation and progressive brain changes in schizophrenia. Br J Pharmacol. 2016;173(4):666-80. https://doi.org/10.1111/bph.13364 PMid:26455353
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