Assessment of Urinary Kidney Injury Molecule-1 as an Indicator of Early Renal Insult in Children with Cystic Fibrosis

Walaa Shahin; Ahmed Bader; Rawdah Ahmed; Mona Alattar; Mona Alfalaki; Walaa Rabie

doi:10.3889/oamjms.2020.4160

Authors

Walaa Shahin Department of Paediatrics, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
Ahmed Bader Department of Paediatrics, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
Rawdah Ahmed Department of Paediatrics, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
Mona Alattar Department of Paediatrics, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
Mona Alfalaki Department of Paediatrics, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
Walaa Rabie Department of Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

DOI:

https://doi.org/10.3889/oamjms.2020.4160

Keywords:

Cystic Fibrosis, Urinary β2–Microglobulin, Urinary kidney injury molecule-1 (KIM-1), Renal, Children

Abstract

BACKGROUND: The risk of acute kidney injury in cystic fibrosis (CF) patients is due to renal tubular affection by CFTR gene.

AIM: Our study aimed at early detection of renal impairment in CF patients, to enable careful monitoring and adjustment of nephrotoxic medications.

METHODS: Fifty patients with CF were enrolled in our study; they were age- and sex-matched to 40 healthy control children. All subjects were screened by urine analysis, measurements of kidney function tests, fractional excretion of sodium, β2-microglobulin (beta-2-M) excretion, and renal ultrasound examination. Urinary kidney injury molecule-1 (KIM-1) was assayed using ELISA technique.

RESULTS: Both urinary beta-2-M and KIM-1 concentrations were significantly higher in CF patients compared to the control group (p < 0.001). The duration of the disease was significantly positively correlated with the urinary beta-2-M and KIM-1 levels (r = 0.6 and 0.7, respectively; p < 0.01).

CONCLUSIONS: Our results showed that urinary KIM-1 can be considered as a sensitive early indicator of acute renal injury.

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