Protection Effects of Nothopanax scutellarium on Hepatotoxicity of Copper(II) Induced to Experimental Rats

Authors

  • Sri Wahyuni Nasution Doctoral Student of Postgraduate Chemistry Science, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Department of Tropical Medicine, Faculty of Medicine, University of Prima Indonesia, Medan, Indonesia
  • Eti Yerizel Department of Biochemistry, Faculty of Medicine, Andalas University, Padang, Indonesia
  • Zulkarnain Chaidir Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia
  • Rahmiana Zein Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Department of Environmental Analytical Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4238

Keywords:

Copper(II), Hepatotoxicity, Nothopanax scutellarium, Serum glutamic pyruvic transaminase, Serum glutamic oxaloacetic transaminase

Abstract

BACKGROUND: Nothopanax scutellarium is a plant containing substance such as flavonoids, saponins, amygdalin, peroxidase, calcium oxalate, polyphenols, proteins, fats, calcium, phosphorus, iron, and Vitamins A, B1, and C.

AIM: The purpose of this study was to investigate the hepatoprotective effect of N. scutellarium leaves against rats induced with Cu(II).

MATERIALS AND METHODS: Three groups of female Wistar rats (Rattus norvegicus) within the range of age 2.5–3 months were used. Each group was composed of three female rats. Group I was a control given a normal diet and distilled water. Group II was exposed to 1000 mg/L of Cu(II) solution with a dosage of 1 mL × bw/200 g. Group III was given 5 mL of antidote N. scutellarium extract for 7 days then exposed to 1000 mg/L of Cu(II) solution with a dosage of 1 mL × bw/200 g. The blood test (malondialdehyde [MDA], serum glutamic oxaloacetic transaminase [SGOT], and serum glutamic pyruvic transaminase [SGPT]) and histopathology of liver were examined after 5 h of exposure.

RESULTS: The administration of N. scutellarium as hepatoprotective in experimental rats resulted in significant reductions in MDA, SGOT, and SGPT as much as 33.87%, 51.14 %, and 12.57 %, respectively.

CONCLUSION: This study concluded that indicates the increase of the parameters of liver function and stress oxidative parameters including MDA, SGOT, and SGPT.

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Published

2020-04-28

How to Cite

1.
Nasution SW, Yerizel E, Chaidir Z, Zein R. Protection Effects of Nothopanax scutellarium on Hepatotoxicity of Copper(II) Induced to Experimental Rats. Open Access Maced J Med Sci [Internet]. 2020 Apr. 28 [cited 2024 Mar. 28];8(A):283-6. Available from: https://oamjms.eu/index.php/mjms/article/view/4238

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