Protection Effects of Nothopanax scutellarium on Hepatotoxicity of Copper(II) Induced to Experimental Rats

Sri Wahyuni  Nasution; Eti  Yerizel; Zulkarnain  Chaidir; Rahmiana  Zein

doi:10.3889/oamjms.2020.4238

Authors

Sri Wahyuni Nasution Doctoral Student of Postgraduate Chemistry Science, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Department of Tropical Medicine, Faculty of Medicine, University of Prima Indonesia, Medan, Indonesia
Eti Yerizel Department of Biochemistry, Faculty of Medicine, Andalas University, Padang, Indonesia
Zulkarnain Chaidir Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia
Rahmiana Zein Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Department of Environmental Analytical Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4238

Keywords:

Copper(II), Hepatotoxicity, Nothopanax scutellarium, Serum glutamic pyruvic transaminase, Serum glutamic oxaloacetic transaminase

Abstract

BACKGROUND: Nothopanax scutellarium is a plant containing substance such as flavonoids, saponins, amygdalin, peroxidase, calcium oxalate, polyphenols, proteins, fats, calcium, phosphorus, iron, and Vitamins A, B1, and C.

AIM: The purpose of this study was to investigate the hepatoprotective effect of N. scutellarium leaves against rats induced with Cu(II).

MATERIALS AND METHODS: Three groups of female Wistar rats (Rattus norvegicus) within the range of age 2.5–3 months were used. Each group was composed of three female rats. Group I was a control given a normal diet and distilled water. Group II was exposed to 1000 mg/L of Cu(II) solution with a dosage of 1 mL × bw/200 g. Group III was given 5 mL of antidote N. scutellarium extract for 7 days then exposed to 1000 mg/L of Cu(II) solution with a dosage of 1 mL × bw/200 g. The blood test (malondialdehyde [MDA], serum glutamic oxaloacetic transaminase [SGOT], and serum glutamic pyruvic transaminase [SGPT]) and histopathology of liver were examined after 5 h of exposure.

RESULTS: The administration of N. scutellarium as hepatoprotective in experimental rats resulted in significant reductions in MDA, SGOT, and SGPT as much as 33.87%, 51.14 %, and 12.57 %, respectively.

CONCLUSION: This study concluded that indicates the increase of the parameters of liver function and stress oxidative parameters including MDA, SGOT, and SGPT.

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