Comparison of Serum Matrix Metalloproteinase-9 Value in Spondylitis Tuberculous with Degenerative Spine Disease

Otman Siregar; Yohanes Augustinus; Benny Benny; Ahmad Jabir Rahyussalim

doi:10.3889/oamjms.2020.4258

Authors

Otman Siregar Spine Division, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik Hospital, Medan, Indonesia
Yohanes Augustinus 2Resident of Orthopaedic and Traumatology, Faculty of Medicine UniversitasSumatera Utara/ Haji Adam Malik Hospital-Medan
Benny Benny Faculty of Medicine Universitas Sumatera Utara/Haji Adam Malik Hospital-Medan
Ahmad Jabir Rahyussalim Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4258

Keywords:

Matrix metalloproteinase, Spondylitis tuberculous, Degenerative spine disease

Abstract

AIM: We aimed to evaluate and compare the expression of MMP-9 in TB spondylitis using serum levels in the blood of patients suffering from TB spondylitis and compared to the control group; in this case, the control group in this study was patients with degenerative diseases of the spine.

METHODS: Fourteen subjects were divided into two groups, with seven subjects of spondylitis tuberculous (TB) (ST) and seven subjects of degenerative spine disease (DSD) in the period from December 2017 to November 2018 who were included in the inclusion criteria included in this study and blood sampling was taken for the examination of serum matrix metalloproteinase-9 (MMP-9) levels.

RESULTS: There were significant differences in serum MMP-9 levels between ST and DSDs with a significance value of 0.002 (p < 0.05) with low serum MMP-9 levels in the ST study group 1857.14 ± 377.96 and mean in the control group 857.14 ± 243.97. There were significant differences in serum MMP-9 levels between ST and DSDs with a significance value of 0.002 (p < 0.05) with low serum MMP-9 levels in the ST study group 1857.14 ± 377.96 and mean in the control group 857.14 ± 243.97.

CONCLUSION: Patients suffering from ST have higher serum MMP-9 levels than patients with DSD, although MMP-9 is not a specific marker examination for ST, the results of this study can be suggestive into that can help to evaluate enzyme activity in patients with ST disease.

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References

Lindsay, KW, Bone I, dan Calldaner R. Spinal cord and root compression. In: Neurology and Neurosurgery Illustrated. 2nd ed. Edinburgh: Churchill Livingstone; 1991. p. 388.

Martini FH, Welch K. The lymphatic system and Immunity. In: Fundamentals of Anatomy and Physiology. 5th ed. New Jersey: Upper Saddle River; 2001. p. 132-51.

Tachdjian MO. Tuberculosis of the spine. In: Pediatric Orthopedics. 2nd ed. Philadelphia, PA: W.B. Saunders; 1990. p. 1449-54.

Graham JM, Kozak J. Spinal tuberculosis. In: Hochschule SH, Cotler HB, Guyer RD, editors. Rehabilitation of the Spine: Science and Practice. St. Louis: Mosby-Year Book, Inc.; 1993. p. 387-90.

Patil T, Garg RK, Jain A, Goel MM, Malhotra HS, Verma R, et al. Serum and CSF cytokines and matrix metalloproteinases in spinal tuberculosis. Inflamm Res. 2015;64(2):97-106. https:// doi.org/10.1007/s00011-014-0786-5. PMid:25503789

Salgame P. MMPs in tuberculosis: Granuloma creators and tissue destroyers. J Clin Invest. 2011;121(5):1686-8. https://doi. org/10.1172/jci57423 PMid:21519148

Agarwal P, Rathi P, Verma R, Pradhan CG. Tuberculous Spondylitis: “Global lesion”. Special Issues on Tuberkulosa. Bombay: Bombay Hospital Journal; 1999.

Hrabec E, Strek M, Zieba M, Kwiatkowska S, Hrabec Z. Circulation level of matrix metalloproteinase-9 is correlated with disease severity in tuberculosis patients. Int J Tuberc Lung Dis. 2002;6(8):713-9. PMid:12150484

Leibert E, Haralambou G. Tuberkulosa. In: Rom WN, Garay S, editors. Spinal Tuberculosis. Philadelphia, PA: Lippincott, Williams, and Wilkins; 2004.

López-Otín C, Palavalli LH, Samuels Y. Protective roles of matrix metalloproteinases: From mouse models to human cancer. Cell Cycle. 2009;8(22):3657-62. https://doi.org/10.4161/ cc.8.22.9956 PMid:19844170

Singh S, Dawar H, Das K, Mohapatra B, Prasad S. Functional and radiological outcomes of anterior decompression and posterior stabilization via posterior transpedicular approach in thoracic and thoracolumbar Pott’s disease: A retrospective study. Asian Spine J. 2017;11(4):618-26. https://doi.org/10.4184/ asj.2017.11.4.618 PMid:28874981