Efficacy of Albendazole Against Soil-transmitted Helminthiasis among Children in Asia: Systematic Review

M. Mohd Faizal; BP  Anaanthan; M. Nur   Ezdiani; M. N.  Azmawati; A.  Norfazilah; F. G. Hasanain; Mohammad Safrree  Jeffree; Syed Sharizman  Syed Abdul Rahim; Mohd Rohaizat  Hassan

doi:10.3889/oamjms.2020.4305

Authors

M. Mohd Faizal Department of Community Health, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, Malaysia; Department of Community and Family Medicine, Faculty of Medicine and Health Science, Universiti Malaysia Sabah
BP Anaanthan Department of Community Health, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, Malaysia; Department of Pharmacy, Hospital Tuanku Ja’afar, 70300 Seremban, Negri Sembilan, Malaysia
M. Nur Ezdiani Department of Community Health, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, Malaysia
M. N. Azmawati Department of Community Health, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, Malaysia
A. Norfazilah Department of Community Health, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, Malaysia
F. G. Hasanain Department of Community Medicine, International Medical School, Management and Science University, Malaysia
Mohammad Safrree Jeffree Department of Community and Family Medicine, Faculty of Medicine and Health Science, Universiti Malaysia Sabah
Syed Sharizman Syed Abdul Rahim Department of Community and Family Medicine, Faculty of Medicine and Health Science, Universiti Malaysia Sabah
Mohd Rohaizat Hassan Department of Community Health, Universiti Kebangsaan Malaysia, Kuala Lumpur, 56000, Malaysia

DOI:

https://doi.org/10.3889/oamjms.2020.4305

Keywords:

albendazole, asia, efficacy, soil-transimtted helminths

Abstract

BACKGROUND: The World health organization reported that 875 million children worldwide require antihelminth preventive chemotherapy annually. Vast majority of STH infections (67%) and YLDs (68%) occurred in Asia.

METHODS: A systematic search was performed for relevant titles, abstract, and keywords from Cochrane Library, PubMed, and Scopus around October 2018 based on the PICO strategy. Out of 173 papers that were evaluated, final assessment for eligibility had yielded a total of five papers to be included for analysis covering period from 2013 to 2018.

RESULTS: Of the five selected studies, three were randomized controlled trial, one was cohort and another one was described more like a quasi-experimental trial. All infection intensity showed improvement post-intervention. Four of the five studies used Kato Katz as diagnostic method with one combined it with Baermann techniques. One used McMaster egg counting method. All except one study tested albendazole efficacy in their study either alone or in combination with other chemotherapy such as diethyl carbazide or combining with education pamphlet. Egg reduction rate was reported as low as 63% and as high as 99.9%.

CONCLUSION: In general, albendazole is efficacious enough to control STH.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Jourdan PM, Lamberton PH, Fenwick A, Addiss DG. Soil-transmitted helminth infections. Lancet. 2018;391(10117):252- 65. https://doi.org/10.1016/s0140-6736(17)31930-x PMid:28882382

World Health Organization. Investing to Overcome the Global Impact of Neglected Tropical Diseases. Third WHO Report on Neglected Tropical Diseases. Geneva: World Health Organization; 2015. https://doi.org/10.1128/9781555818753. ch10

Stolk WA, Kulik MC, le Rutte EA, Jacobson J, Richardus JH, de Vlas SJ, et al. Between-country inequalities in the neglected tropical disease burden in 1990 and 2010, with projections for 2020. PLoS Negl Trop Dis. 2016;10(5):e0004560. https://doi. org/10.1371/journal.pntd.0004560 PMid:27171193

Pullan RL, Smith JL, Jasrasaria R, Brooker SJ. Global numbers of infection and disease burden of soil transmitted helminth infections in 2010. Parasit Vectors. 2014;7(1):37. https://doi. org/10.1186/1756-3305-7-37 PMid:24447578

Webster JP, Molyneux DH, Hotez PJ, Fenwick A. The contribution of mass drug administration to global health: Past, present and future. Philos Trans R Soc Lond B Biol Sci. 2014;369(1645):20130434. https://doi.org/10.1098/ rstb.2013.0434 PMid:24821920

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The prisma statement. PLoS Med. 2009;6(7):e1000097. https://doi. org/10.1371/journal.pmed.1000097 PMid:19621072

Jadad AR, Moore RA, Carroll D, Jenkinson C, ReynoldsDJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials. 1996;17(1):1-12. https://doi.org/10.1016/0197-2456(95)00134-4 PMid:8721797

Moser W, Sayasone S, Xayavong S, Bounheuang B, Puchkov M, Huwyler J, et al. Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos: A randomised, single-blind trial. Lancet Infect Dis. 2018;18(7):729-37. https://doi.org/10.1016/ s1473-3099(18)30220-2

Levecke B, Montresor A, Albonico M, Ame SM, Behnke JM, Bethony JM, et al. Assessment of anthelmintic efficacy of mebendazole in school children in six countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis. 2014;8(10):e3204. https://doi.org/10.1371/journal.pntd.0003204 PMid:25299391

Liu C, Lu L, Zhang L, Luo R, Sylvia S, Medina A, et al. Effect of deworming on indices of health, cognition, and education among schoolchildren in Rural China: A cluster-randomized controlled trial. Am J Trop Med Hyg. 2017;96(6):1478-89. https://doi.org/10.4269/ajtmh.16-0354 PMid:28093533

Yap P, Du ZW, Wu FW, Jiang JY, Chen R, Zhou XN, et al. Rapid re-infection with soil-transmitted helminths after triple-dose albendazole treatment of school-aged children in Yunnan, people’s republic of China. Am J Trop Med Hyg. 2013;89(1):23- 31. https://doi.org/10.4269/ajtmh.13-0009 PMid:23690551

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The prisma statement. Ann Intern Med. 2009;151(4):264-9. https://doi. org/10.7326/0003-4819-151-4-200908180-00135 PMid:19622511

Sunish I, Rajendran R, Munirathinam A, Kalimuthu M, Kumar V, Nagaraj J, et al. Impact on prevalence of intestinal helminth infection in school children administered with seven annual rounds of diethyl carbamazine (DEC) with albendazole. Indian J Med Res. 2015;141(3):330-9. https://doi. org/10.4103/0971-5916.156622 PMid:25963494

Cuzick J. Forest plots and the interpretation of subgroups. Lancet. 2005;365(9467):1308. https://doi.org/10.1016/ s0140-6736(05)61026-4 PMid:15823379

Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: Systematic review and meta-analysis. JAMA. 2008;299(16):1937-48. https://doi.org/10.1001/ jama.299.16.1937 PMid:18430913

Viswanath A, Williams M. Trichuris Trichiura (Whipworm, Roundworm). Treasure Island, FL: StatPearls; 2018.