Use of Biomaterials for Periodontal Regeneration: A Review

Bylbyl Reçica; Mirjana Popovska; Amella Cana; Lindita Zendeli Bedxeti; Urim Tefiku; Spiro Spasovski; Ana Spasovska-Gjorgovska; Teuta Kutllovci; Jehona F. Ahmedi

doi:10.3889/oamjms.2020.4354

Authors

Bylbyl Reçica Department of Dental Emergency, University Dental Clinical Centre, Pristina, Kosovo
Mirjana Popovska Department of Periodontology and Oral Pathology, University Dental Clinical Centre, Faculty of Dentistry, “Ss. Cyril and Methodius University”, Skopje, Republic of Macedonia
Amella Cana Department of Orthodontics, University Dental Clinical Centre, Skopje, Republic of Macedonia
Lindita Zendeli Bedxeti Department of Periodontology and Oral Pathology, University Dental Clinical Centre, Faculty of Dentistry, “Ss. Cyril and Methodius University”, Skopje, Republic of Macedonia
Urim Tefiku “Denta Med” - Desmoret e Golakut n.n., Pristina, Kosovo
Spiro Spasovski “Dr. Spasovski”, Skopje, Republic of Macedonia
Ana Spasovska-Gjorgovska PZU “Ilinden 96, Skopje, Republic of Macedonia
Teuta Kutllovci Department of Pedodontics and Preventive Dentistry, University Clinical Centre of Kosovo, Pristina, Kosovo
Jehona F. Ahmedi Department of Oral Surgery, University Dental Clinical Center Pristina, Pristina, Kosovo

DOI:

https://doi.org/10.3889/oamjms.2020.4354

Keywords:

Periodontal disease, Biomaterials, Bio-Oss, Platelet-rich fibrin, 4MATRIX

Abstract

BACKGROUND: Management of bone periodontal defects, destruction, and loss of the alveolar bone is considered a challenge for modern periodontal regeneration and implant dentistry. Numerous of biomaterials are being used in periodontal regenerative treatment.

AIM: This study aims to know the characteristics of biomaterials and their efficiency in periodontal surgical treatment as regenerative therapy.

METHODS: A systematic review of the literature considering reviews, clinical studies, original papers, and articles from electronic data has been used.

RESULTS: Different biomaterials such as Straumann® Emdogain®, Geistlich Bio-Oss®, MIS 4MATRIX – Bone Graft, Platelet-rich fibrin (PRF), Mis Bone-4MATRIX, and PRF are being used for periodontal regeneration treatment, hence revealing more effective outcomes when combined. PRP together with conventional grafting procedures may be a beneficial treatment approach, guided tissue regeneration with bioabsorbable membranes in combination with Bio-Oss are stable on a long-term basis.

CONCLUSION: Biomaterials being used in periodontal surgical treatment have the different regenerative ability. The combined use of biomaterials might result in a better clinical outcome. There are also a number of other biomaterials used to treat periodontal regeneration, but generally all have the same ability and the same molecular structure as highlighted in this literature review.

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References

Dentino A, Lee S, Mailhot J, Hefti AF. Principles of periodontology. Periodontol 2000. 2013;61(1):16-53. https://doi. org/10.1111/j.1600-0757.2011.00397.x PMid:23240942

Esposito M, Grusovin MG, Papanikolaou N, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain(R)) for periodontal tissue regeneration in intrabony defects. Cochrane Database Syst Rev. 2009;4:CD003875. https://doi. org/10.1002/14651858.cd003875 PMid:19821315

Pihlstrom BL, Michalowcz BS, Johmson NW. Periodontal diseases. Lancet. 2005;366(9499):1809-20. PMid:16298220

Wang HL, Greenwell H, Fiorellini J, Giannobile W, Offenbacher S, Salkin L, et al. Periodontal regeneration. J Periodontol. 2005;76(9):1601-22. PMid:16171453

Savage A, Eaton KA, Moles DR, Needleman I. A systematic review of definitions of periodontitis and methods that have been used to identify this disease. J Clin Periodontol. 2009;36(6):458- 67. https://doi.org/10.1111/j.1600-051x.2009.01408.x PMid:19508246

Greenstein G, Lamster I. Changing periodontal paradigms: Therapeutic implications. Int J Periodontics Restorative Dent. 2000;20(4):337-57. PMid:11203574

Glickman I, Smulow JB. Periodontal Diseas: Clinical, Radiographic and Histopathologic Features. Philadelphia, PA: Saunders; 1974.

Loe H, Silness J. Periodontal disease in pregnancy I. Prevalence and severity. Acta Odontol Scand. 1963;21:533-51. https://doi. org/10.3109/00016356309011240 PMid:14121956

Löe H. Progress in improving dental health a discussion. J Public Health Dent. 1978;38(4):329-32. https://doi. org/10.1111/j.1752-7325.1978.tb03758.x

Neely JG. Clinical experience with a surgical approach to hydrops. Ann N Y Acad Sci. 2001;942:322-7. PMid:11710474

Löe H. Periodontology in the past 20 years. Tandlaegebladet. 1986;90(18):788-94. PMid:3468647

Mitsis FJ. Hippocrates in the golden age. His life, his work 79-83. J Periodontol. 1965;36:177-87.

Faurhard P. Le Chirurgien-Dentiste. 2nd ed. Paris: Mariet-Le, 1746. p. 1-494.

Hunter J. The Natural History of the Human Teeth, Explaining Their Structure Use, Formation, Growth and Disease. London: Johnson; 2007. p. 1-128.

Hunter J. A practical treatise on the diseases of the teeth. In: Longbottom B, editors. A Treatise on Dentistry. Baltimore: Prentiss and Cole; 1802. p. 1-66.

Krayer JW, Rees TI. Histologic observation on the topography of a human periodontal pocket viewed intransverse step-serial section. J Periodontol. 1993;58(3):122-34. https://doi. org/10.1902/jop.1993.64.7.585

Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL Jr., Socransky SS. The effect of SRP on the clinical and microbiological parameters of periodontal diseases. J Clin Periodontol. 1997;24(5):324-34. https://doi.org/10.1111/j.1600- 051x.1997.tb00765.x PMid:9178112

Bowers GM, Chadroff B, Carnevale R, Mellonig J, Corio R, Emerson J, et al. Histologic evaluation of new attachment apparatus formation in humans. Part I. J Periodontol. 1989;60(12):664-74. https://doi.org/10.1902/jop.1989.60.12.664 PMid:2614631

Bowers GM, Chadroff B, Carnevale R, Mellonig J, Corio R, Emerson J, et al. Histologic evaluation of new attachment apparatus formation in humans. Part II. J Periodontol. 1989;60(12):675-82. https://doi.org/10.1902/jop.1989.60.12.675 PMid:2614632

Döri F, Arweiler N, Húszár T, Gera I, Miron RJ, Sculean A. Five-year results evaluating the effects of platelet-rich plasma on the healing of intrabony defects treated with enamel matrix derivative and natural bone mineral. J Periodontol. 2013;84(11):1546-55. https://doi.org/10.1902/jop.2013.120501 PMid:23327604

Arenaz-Búa J, Luaces-Rey R, Sironvalle-Soliva S, Otero- Rico A, Charro-Huerga E, Patiño-Seijas B, et al. A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction. Med Oral Patol Oral Cir Bucal. 2010;15(3):e483-9. https://doi.org/10.4317/ medoral.15.e483 PMid:20038911

Koop R, Merheb J, Quirynen M. Periodontal regeneration with enamel matrix derivative in reconstructive periodontal therapy: A systematic review. J Periodontol. 2012;83(6):707-20. https:// doi.org/10.1902/jop.2011.110266 PMid:22050544

Najeeb S, Khurshid Z, Agwan MA, Ansari SA, Zafar MS, Matinlinna JP. Regenerative potential of platelet rich fibrin (PRF) for curing intrabony periodontal defects: A systematic review of clinical studies. Tissue Eng Regen Med. 2017;14(6):735-42. https://doi.org/10.1007/s13770-017-0079-5 PMid:30603523

Hou X, Yuan J, Aisaiti A, Liu Y, Zhao J. The effect of platelet-rich plasma on clinical outcomes of the surgical treatment of periodontal intrabony defects: A systematic review and meta-analysis. BMC Oral Health. 2016;16(1):71. https://doi. org/10.1186/s12903-016-0261-5 PMid:27531202

Stavropoulos A, Karring T. Five-year results of guided tissue regeneration in combination with deproteinized bovine bone (Bio-Oss) in the treatment of intrabony periodontal defects: A case series report. Clin Oral Investig. 2005;9(4):271-7. https:// doi.org/10.1007/s00784-005-0002-7 PMid:16010581

Agarwal A, Gupta ND, Jain A. Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: A randomized split mouth clinical trail. Acta Odontol Scand. 2016;74(1):36-43. https://doi. org/10.3109/00016357.2015.1035672 PMid:25972081

Pradeep AR, Karvekar S, Nagpal K, Patnaik K, Raju A, Singh P. Rosuvastatin 1.2 mg in situ gel combined with 1: 1 mixture of autologous platelet-rich fibrin and porous hydroxyapatite bone graft in surgical treatment of mandibular class II furcation defects: A randomized clinical control trial. J Periodontol. 2016;87(1):5-13. https://doi.org/10.1902/jop.2015.150131 PMid:26439386

Shah M, Patel J, Dave D, Shah S. Comparative evaluation of platelet-rich fibrin with demineralized freeze-dried bone allograft in periodontal infrabony defects: A randomized controlled clinical study. J Indian Soc Periodontol. 2015;19(1):56-60. https://doi. org/10.4103/0972-124x.145803 PMid:25810594

Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet-rich fibrin and bovine porous bone mineral vs. Platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodontal Res. 2012;47(4):409-17. https://doi.org/10.1111/j.1600-0765.2011.01446.x PMid:22126591

Panda S, Doraiswamy J, Malaiappan S, Varghese SS, Del Fabbro M. Additive effect of autologous platelet concentrates in treatment of intrabony defects: A systematic review and meta-analysis. J Investig Clin Dent. 2016;7(1):13-26. https://doi. org/10.1111/jicd.12117 PMid:25048153

Galgut PN. Oxidized cellulose mesh. II. Using hydroxy-apatite bone grafting material in the treatment of infrabony defects. Biomaterials. 1990;11(8):565-7. https://doi. org/10.1016/0142-9612(90)90079-6 PMid:2279058

Kökdere NN, Baykul T, Findik Y. The use of platelet-rich fibrin (PRF) and PRF-mixed particulated autogenous bone graft in the treatment of bone defects: An experimental and histomorphometrical study. Dent Res J (Isfahan). 2015;12(5):418-24. https://doi.org/10.4103/1735-3327.166188 PMid:26604954

Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: From the wound healing to bone regeneration. Immun Ageing. 2013;10(1):23. https://doi.org/10.1186/1742-4933-10-23 PMid:23763951

Célio-Mariano R, de Melo WM, Carneiro-Avelino C. Comparative radiographic evaluation of alveolar bone healing associated with autologous platelet-rich plasma after impacted mandibular third molar surgery. J Oral Maxillofac Surg. 2012;70(1):19-24. https:// doi.org/10.1016/j.joms.2011.03.028 PMid:21778014

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e37- 44. https://doi.org/10.1016/j.tripleo.2005.07.008 PMid:16504849

Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016;20(9):2353-60. https://doi.org/10.1007/ s00784-016-1719-1 PMid:26809431

Needleman IG, Worthington HV, Giedrys-Leeper E, Tucker RJ. Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev. 2006;2:CD001724. https://doi. org/10.1002/14651858.cd001724 PMid:16625546

Sebben AD, Hoff G, Klein CP, Freitas TA, Assad C, Santos LA, et al. Comparative study on use of platelet-rich plasma alone and in combination with alpha-tricalcium phosphate cement for bone repair in rats. Rev Bras Ortop. 2015;47(4):505-12. https:// doi.org/10.1016/s2255-4971(15)30137-3 PMid:27047859

Ozdemir B, Okte E. Treatment of intrabony defects with beta-tricalciumphosphate alone and in combination with platelet-rich plasma. J Biomed Mater Res B Appl Biomater. 2012;100(4):976- 83. https://doi.org/10.1002/jbm.b.32660 PMid:22287494

Gojkov-Vukelic M, Hadzic S, Gojkov E. Evaluation of efficacy of surgical periodontal therapy with the use of bone graft in the treatment of periodontal intrabony defects. Med Arch. 2017;71(3):208-11. https://doi.org/10.5455/ medarh.2017.71.208-211 PMid:28974835

Gokhale ST, Dwarakanath H. The use of a natural osteoconductive porous bone mineral (Bio OssTM) in infrabony periodontal defects. J Indian Soc Periodontol. 2012;16:247-52. https://doi.org/10.4103/0972-124x.99270 PMid:23055593

Chhina S. A 12 months clinical and radiographic study to assess the efficacy of open flap debridement and subepithelial connective tissue graft in management of supracrestal defects. J Int Oral Health. 2015;7(8):108-13.PMid:26464551

Trombelli L. Which reconstructive procedures are effective for treating the periodontal intraosseous defect? Periodontol 2000. 2005;37:88-105. https://doi. org/10.1111/j.1600-0757.2004.03798.x PMid:15655027

Patel S, Dhillon MS, Agarwal S, Marwaha N, Jain A. Treatent with platelet rich plasma is more effective than placebo for knee osteoarthritis: A prospective, double-blind, randomized trial. Am J Sports Med. 2013;41:356-64. https://doi. org/10.1177/0363546512471299

Marx Re, Carlson RE, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):638-46. https://doi.org/10.1016/ s1079-2104(98)90029-4 PMid:9638695

Kobayashi E, Fluckiger L, Fujioka-Kobayashi M, Sawada K, SculeanA, Schaller B, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016;20(9):2353-60. https://doi.org/10.1007/ s00784-016-1719-1 PMid:26809431

Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: From the wound healing to BNE regeneration. Immun Ageing. 2013;10:23. https://doi.org/10.1186/1742-4933-10-23

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: Platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e45-50. https://doi.org/10.1016/j.tripleo.2005.07.009

Ehrenfest DM, Bielecki T, Mishra A, Borzini P, Inchingolo F, Sammartino G, et al. In search of a consensus terminology in the field of platelet concentrates for surgical use: Platelet-rich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes. Curr Pharm Biotechnol. 2012;13(7):1131-7. https://doi.org/10.2174/138920112800624328 PMid:21740379

Kawazoe T, Kim HH. Tissue augmentation by white blood cell-containing platelet-rich plasma. Cell Transplant. 2012;21(2-3): 601-7. https://doi.org/10.3727/096368911x605538 PMid:22793069

Perut F, Filardo G, Mariani E, Cenacchi A, Pratelli L, Devescovi V, et al. Preparation method and growth factor content of platelet concentrate influence the osteogenic differentiation of bone marrow stromal cells. Cytotherapy. 2013;15(7):830-9. https:// doi.org/10.1016/j.jcyt.2013.01.220 PMid:23731763

Pirraco RP, Reis RL, Marques AP. Effect of monocytes/ macrophages on the early osteogenic differentiation of hBMSCs. J Tissue Eng Regen Med. 2013;7(5):392-400. https:// doi.org/10.1002/term.535 PMid:22392849

Zumstein MA, Berger S, Schober M, Boileau P, Nyffeler RW, Horn M, et al. Leukocyte- and platelet-rich fibrin (L-PRF) for long-term delivery of growth factor in rotator cuff repair: Review, preliminary results and future directions. Curr Pharm Biotechnol. 2012;13:1196-206. https://doi. org/10.2174/138920112800624337 PMid:21740372

Dvorak HF, Harvey VS, Estrella P, Brown LF, McDonagh J, Dvorak AM. Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab Invest. 1987;57:673-86. PMid:2447383