Cognitive Profile of Patients with Schizophrenia in North Sumatera Indonesia

Mustafa M. Amin; Elmeida Effendy; Bahagia Loebis

doi:10.3889/oamjms.2020.4508

Authors

Mustafa M. Amin Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Jl. dr. T. Mansur No.5 Medan, Indonesia
Elmeida Effendy Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Jl. dr. T. Mansur No.5 Medan, Indonesia
Bahagia Loebis Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Jl. dr. T. Mansur No.5 Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4508

Keywords:

Mini-mental state examination, Cognitive function, Schizophrenia

Abstract

BACKGROUND: Cognitive dysfunction is one of the characteristics of schizophrenia traditionally experienced by elderly patients. In the past 25 years, studies have proven that the cognitive dysfunction is an early characteristic of this disease, besides introversion, drug abuse, suicidal behavior, and depressive symptoms. The mini-mental state examination is a test designed to identify functional and organic disorders in psychiatric patients. North Sumatera is often considered as “small Indonesia” due to the variety of tribes live in the province; therefore, a study in relation with the cognitive profile of patients with schizophrenia (PwS) is needed.

AIM: We aimed to analyze cognitive function in PwS in the North Sumatera.

METHODS: The study was a descriptive study with a cross-sectional approach of cognitive profile of PwS stressing in the age, sex, education, and illness duration of the patients.

RESULTS: The results of the study using 200 subjects found that the most affected gender were male (62.5%), between the ages of 25–34 years (46%), with secondary school education background (55.5%), and with an illness duration >1 year (64.0%). The results showed that cognitive function in schizophrenic patients was probable cognitive dysfunction (56.5%).

CONCLUSIONS: From the results of this study, it was found that the most affected subjects were men, between 25 and 34 years, with high school education, and the illness lasted more than 1 year. Most of the schizophrenic patients experienced probable cognitive dysfunction.

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References

Sadock BJ, Sadock VA. Kaplan and Sadock’s Synopsis of Psychiatry Behavioral Science/Clinical Psychiatry. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2007.

Weickert TW, Goldberg TE, Gold JM, Bigelow LL, Egan MF, Weinberger DR. Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Arch Gen Psychiatry. 2000;57(9):907-13. https://doi. org/10.1001/archpsyc.57.9.907 PMid:10986554

Folstein MF, Folstein SE, McHugh PR. Mini-mental state exam. In: Rush AJ Jr., Pincus HA, First MB, Blacker D, Endicott J, Keith SJ, et al, editors. Handbook of Psychiatric Measures. Washington, DC: American Psychiatric Association; 2000. p. 422-49. https://doi.org/10.1016/0022-3956(75)90026-6

Goldberg TE, Green MF. Neurocognitive functioning in patients with schizophrenia: An overview. In: Davis KL, Charney D, Coyle JT, Nemeroff CB, editors. Neuropsychopharmacology: The Fifth Generation of Progress. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2002. p. 657-69. https://doi. org/10.1056/nejm200210173471624

Ong HL, Subramaniam M, Abdin E, Wang P, Vaingankar JA, Lee SP, et al. Performance of mini-mental state examination (MMSE) in long-stay patients with schizophrenia or schizoaffective disorders in a psychiatric institute. Psychiatry Res. 2016;241:256-62. https://doi.org/10.1016/j.psychres.2016.04.116 PMid:27203153

Portney LG, Watkins MP. Foundations of Clinical Research. 2nd ed. Upper Saddle River, USA: Prentice Hall Inc.; 2000.

Kelly C, Sharkey V, Morrison G, Allardyce J, McCreadie R. Nithsdale schizophrenia surveys 20: Cognitive function in a catchment-area-based population of patients with schizophrenia. Br J Psychiatry. 2000;177:348-53. https://doi. org/10.1192/bjp.177.4.348 PMid:11116777

Talreja BT, Shah S, Kataria L. Cognitive function in schizophrenia and its association with socio-demographic factors. Ind Psychitary J. 2013;22(1):47-53. https://doi. org/10.4103/0972-6748.123619 PMid:24459374

Arapidis K, Rafou-Arapidi T, Taratsidou I, Fokas K, Kaprinis G. Assessment of cognitive function with MMSE in chronic schizophrenic inpatients. Ann Gen Psychiatry. 2006;5(1):S309. https://doi.org/10.1186/1744-859x-5-s1-s309

World Health Organization. International Classification of Disease and Related Health Problems. 10th ed. Geneva: World Health Organization; 1993.

Fisekovic S, Memic A, Pasalic A. Correlation between MOCA and MMSE for the assessment of cognition in schizophrenia. Acta Inform Med. 2012;20(3):186-9. https://doi.org/10.5455/ aim.2012.20.186-189 PMid:23322976

Lee J, Green MF, Nuechterlein KH, Swerdlow NR, Greenwood TA, Hellemann GS, et al. The effects of age and sex on cognitive impairment in schizophrenia: Findings from the consortium on the genetics of schizophrenia (COGS) study. PLoS One. 2020;15(5):e0232855. https://doi.org/10.1371/ journal.pone.0232855 PMid:32401791

Han M, Huang XF, Chen DC, Xiu MH, Hui L, Liu H, et al. Gender differences in cognitive function of patients with chronic schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2012;39(2):358-63. https://doi.org/10.1016/j. pnpbp.2012.07.010 PMid:22820676

Li R, Ma X, Wang G, Yang J, Wang C. Why sex differences in schizophrenia? J Transl Neurosci (Beijing). 2016;1(1):37-42. PMid:29152382

Zhang B, Han M, Tan S, De Yang F, Tan Y, Jiang S, et al. Gender differences measured by the MATRICS consensus cognitive battery in chronic schizophrenia patients. Sci Rep. 2017;7(1):11821. https://doi.org/10.1038/s41598-017-12027-w PMid:28928440

Antonova E, Sharma T, Morris R, Kumari V. The relationship between brain structure and neurocognition in schizophrenia: A selective review. Schizophr Res. 2004;70(2-3):117-45. https:// doi.org/10.1016/j.schres.2003.12.002 PMid:15329292

Geisler D, Walton E, Naylor M, Roessner V, Lim KO, Schulz CS, et al. Brain structure and function correlates of cognitive subtypes in schizophrenia. Psychiatry Res. 2015;234(1):74-83. https://doi.org/10.1016/j.pscychresns.2015.08.008 PMid:26341950

Kalwa A, Rzewuska M, Borkowska A. Cognitive dysfunction progression in schizophrenia-relation to functional and clinical outcome. Arch Psychiatry Psychother. 2012;14(1):5-13.

Ko YH, Joe SH, Cho W, Park JH, Lee JJ, Jung IK, et al. Estrogen, cognitive function and negative symptoms in female schizophrenia. Neuropsychobiology. 2006;53(4):169-75. https:// doi.org/10.1159/000093780 PMid:16763376

Wciórka J, Bembenek A, Hintze B, Kühn-Dymecka A. Schizophrenic disorders-do cognitive dysfunctions relate to course characteristics and the psychopathological picture? Arch Psychiatry Psychother. 2007;4:5-17.