The Relationship between Endothelial Nitric Oxide Synthase with Dyslipidemia in Coronary Heart Disease


  • Eryati Darwin Department of Histology, Faculty of Medicine, Universitas Andalas, Padang, West Sumatera, Indonesia
  • Eka Fithra Elfi Department of Cardiology, Faculty of Medicine, Universitas Andalas, Padang, West Sumatera, Indonesia
  • Eva Decroli Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, West Sumatera, Indonesia
  • Dwitya Elvira Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, West Sumatera, Indonesia



Coronary heart disease, Dyslipidemia, Endothelial nitric oxide synthase


BACKGROUND: Dyslipidemia is a medical condition that refers to an abnormal of blood lipids level, most common is hyperlipidemia. Elevation of blood lipid such as cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, or a low high-density lipoprotein (HDL) cholesterol level induces disturbance of endothelial function. Endothelial dysfunction in dyslipidemia is in large part due to a reduced bioavailability of nitric oxide (NO) which is synthesized by endothelial NO synthase (eNOS) which will trigger the development of atherosclerosis, and increases the risk of coronary heart disease (CHD).

AIM: This study aims to determine the relationship of lipid profiles of dyslipidemia with eNOS levels in CHD patients.

MATERIALS AND METHODS: This study design was a cross-sectional study. The sample in this study was 26 patients which diagnosed as CHD of outpatients in the department of cardiology of a regional general hospital and fulfilled the inclusion and exclusion criteria. Fifteen healthy individuals who come for the general check-up were included as a control group. Blood samples were collected for measurements of eNOS levels and lipid profiles that carried out according to laboratory standards. Statistical analyses were conducted using analysis of variance and Shapiro–Wilk test.

RESULTS: The results of this study showed that eNOS levels in the group of CHD patients (24.174 ± 7.136 ng/ml) were significantly lower (p < 0.05) than those in the control group (72.092 ± 30.065 ng/ml). The mean of triglycerides and HDL levels has a weak correlation with the level of eNOS (p > 0.05). The mean of LDL level has moderately positive correlation with eNOS, while cholesterol has a moderate negative correlation with the level of eNOS (p > 0.05).

CONCLUSION: This study concluded that high cholesterol levels and low HDL levels in dyslipidemia condition were correlated with eNOS, which has a protective function in CHD.


Download data is not yet available.


Metrics Loading ...

Plum Analytics Artifact Widget Block


Sayols BS, Lluís GC, Lucas G, Elosua R. Pathogenesis of coronary artery disease: Focus on genetic risk factors and identification of genetic variants. Appl Clin Genet. 2014;7:15-32. PMid:24520200

World Health Organization. Global Atlas on Cardiovascular Disease Prevention and Control. Geneva: World Health Organization; 2011.

Sanchis GF, Perez QC, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016;4(13):256. PMid:27500157

Marzilli M, Merz NB, Boden WE, Bonow RO, Capozza PG, Chilian WM, et al. Obstructive coronary atherosclerosis and ischemic heart disease: An elusive link! J Am Coll Cardiol. 2012;60(11):951-6. PMid:22954239

Sanz J, Moreno PR, Fuster V. The year in atherothrombosis. J Am Coll Cardiol. 2013;62(13):1131-43. PMid:23916939

Leon A, Bronas UG. Dyslipidemia and risk of coronary heart disease: Role of lifestyle approaches for its management. Am J Lifestyle Med. 2009;3(4);257-73.

Shaima C, Moorthi PV, Shaheen NK. Cardiovascular diseases: Traditional and non-traditional risk factors. J Med Allied Sci. 2016;6(2):46-51.

Hajar R. Risk factors for coronary artery disease: Historical perspectives. Heart Views. 2017;18(3):109-14. PMid:29184622

Bentzon JF, Otsuka F, Virmani R, Falk E. Mechanisms of plaque formation and rupture. Circ Res. 2014;114(12):1852-66. PMid:24902970

Kim JA, Montagnani M, Chandrasekran S, Michael J, Quon MJ. Role of lipotoxicity in endothelial dysfunction. Heart Fail Clin. 2012;8(4):589-607. PMid:22999242

Heiss C, Rodriguez MA, Kelm M. Central role of eNOS in the maintenance of endothelial homeostasis. Antioxid Redox Signal. 2015;22(14):1230-42. PMid:25330054

Yang Z, Ming XF. Recent advances in understanding endothelial dysfunction in atherosclerosis. Clin Med Res. 2006;4(1):53-65. PMid:16595793

Towfighi A, Zheng L, Ovbiagele B. Sex-specific trends in midlife coronary heart disease risk and prevalence. Arch Intern Med. 2009;169(19):1762-6. PMid:19858433

Maas AH, Appelman YE. Gender differences in coronary heart disease. Neth Heart J. 2010;18(12):598-602. PMid:21301622

Abd AM, Goyfman M, Chaus A, Dabbous F, Tamura L, Sandfort V, et al. The correlation of dyslipidemia with the extent of coronary artery disease in the multiethnic study of atherosclerosis. J Lipids. 2018;2018:1-9.

Orozco BD, Gil GV, Redon J, Martin MJ, Pallares CV, Navarro PJ, et al. Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study. PLoS One. 2017;12(10):e0186196. PMid:29045483

Förstermann U, Sessa WC. Nitric oxide synthases: Regulation and function. Eur Heart J. 2012;33(7):829-37. PMid:21890489

Kajikawa M, Maruhashi T, Matsumoto T, Iwamoto Y, Iwamoto A, Oda N, et al. Relationship between serum triglyceride levels and endothelial function in a large community-based study. Atherosclerosis. 2016;249:70-5. PMid:27065244

Hermida N, Balligand JL. Low-density lipoprotein-cholesterol-induced endothelial dysfunction and oxidative stress: The role of statins. Antioxid Redox Signal. 2014;20(8):1216-37. PMid:23924077

Tran DA, Diallo D, Delbosc S, Varela PL, Dang QB, Lapergue B, et al. HDL and endothelial protection. Br J Pharmacol. 2013;169(3):493-511. PMid:23488589

Yasunobu HY, Nagata D, Suzuki E, Nishimatsu H, Suzuki J, Nagai R. Diagnosis and treatment of endothelial dysfunction in cardiovascular disease. Int Heart J. 2010;51(1):1-6. PMid:20145343




How to Cite

Darwin E, Elfi EF, Decroli E, Elvira D. The Relationship between Endothelial Nitric Oxide Synthase with Dyslipidemia in Coronary Heart Disease. Open Access Maced J Med Sci [Internet]. 2020 Aug. 12 [cited 2023 Dec. 6];8(A):537-42. Available from:

Most read articles by the same author(s)

1 2 3 > >>