Relationship between Plasma Neuregulin-1 and MDA Levels with Severity of CAD


  • Gestina Aliska Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Andalas, Indonesia
  • Muhammad Fadil Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Andalas, Indonesia
  • Yose Ramda Ilhami Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Andalas, Indonesia
  • Elly Usman Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Andalas
  • Ivan Mahendra Raditya Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Andalas, Indonesia
  • Rahma Tsania Zhuhra Department of Medical Education, Faculty of Medicine, Universitas Andalas, Indonesia
  • Robby Alfadli Undergraduate Program, Faculty of Medicine, Universitas Andalas, Indonesia



malondialdehyde, cardiac injury, coronary arterial disease, severity of CAD, Neuregulin-1


BACKGROUND: Neuregulins (NRGs) are one of the epidermal growth factors (EGF) superfamily, which released in cellular injuries, such as neurons and myocardial cells. Neuregulin-1β (NRG-1β) could be activated when stress happens to myocardial cells, acting as a survival factor to repair the injury. Malondialdehyde (MDA) is also produced during oxidative stress in cardiac injury. In vivo study of myocardial cells in rats and dogs that got ischemic, dilated, and viral cardiomyopathy showed that NRG-1 could improve the injured cardiac performance, attenuated pathological changes, and prolonged survival of the cells.

AIM: We aimed to observe NRG-1 levels in CAD patients in Indonesia, mainly focused in Minang ethnicity. This study also analyzes the relationship between NRG-1 and MDA with CAD’s severity.

METHODS: We measured plasma NRG-1 in 61 nondiabetic patients within 38–82 years old range with STEMI, NSTEMI, and UAP.

RESULTS: We found their plasma NRG1, respectively, was 10.3 (1.9–38.2) ng/ml, 14.3 ± 7.2 ng/ml, and 7.05 (4.5–0.4) ng/mL. Plasma NRG 1 increased in AMI patients.

CONCLUSION: This study concludes that NRG1’s activated during cardiac cells injury, in any AMI.


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How to Cite

Aliska G, Fadil M, Ilhami YR, Usman E, Raditya IM, Zhuhra RT, Alfadli R. Relationship between Plasma Neuregulin-1 and MDA Levels with Severity of CAD. Open Access Maced J Med Sci [Internet]. 2020 Sep. 15 [cited 2024 May 26];8(B):687-91. Available from:

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