Musical Therapy with Balinese Flute Increased Cognitive Function, Brain-derived Neurotrophic Factor Serum Levels, and Decreased Interleukin-6 Serum Levels among the Elderly in West Denpasar Primary Health Clinic

I Made Oka Adnyana; Ni Putu Ayu Putri Mahadewi; A.A.A. Putri Laksmidewi

doi:10.3889/oamjms.2020.4522

Authors

I Made Oka Adnyana Department of Neurology, Division of Headache, Faculty of Medicine, Udayana University, Sanglah Hospital, Denpasar, Bali, Indonesia
Ni Putu Ayu Putri Mahadewi Department of Neurology, Division of Headache, Faculty of Medicine, Udayana University, Sanglah Hospital, Denpasar, Bali, Indonesia
A.A.A. Putri Laksmidewi Department of Neurology, Division of Headache, Faculty of Medicine, Udayana University, Sanglah Hospital, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4522

Keywords:

Balinese flute, cognitive function, BDNF levels, IL-6 levels, traditional music

Abstract

BACKGROUND: Studies have shown the effects of music toward improved cognitive function due to changes in molecular production and signaling through increased messenger secretion, including hormones, neurotransmitters, and growth factor proteins. Most of the studies used Western classical music as an intervention.

AIM: We would like to investigate whether traditional Balinese flute musical composition entitled can improve cognitive function as well as brain-derived neurotrophic factor (BDNF) and interleukin (IL)-6 levels, on par with the Western classical composition.

METHODS: This was a prospective intervention trial involving 40 participants recruited from Primary Health Clinic 2 in West Denpasar, Bali, and divided into two groups. Participants were asked to listen to either “Morning Happiness” by Mr. Agus Teja Sentosa, S. Sn (treatment), or Vivaldi’s composition of “Spring” (control group) for 20 min each day for 21 days. Cognitive evaluation was performed using Montreal Cognitive Assessment (MoCA)-INA and blood sample was withdrawn during the 1^stday for BDNF and IL-6 levels measurement. All statistical analyses were conducted using IBM SPSS Statistics 20.

RESULTS: There was a significant difference between initial and endpoint MoCA-INA test results among treatment and control group (p < 0.001), but there was no significant difference between control and treatment (p = 1.00). BDNF levels differed significantly between initial and endpoint BDNF levels among control group (p < 0.001), but did not differ significantly between control and treatment groups (p = 0.534). There was no significant difference between initial and endpoint IL-6 levels between the control group, but there was a close to statistical difference between of initial and endpoint IL-6 levels among the treatment group (p = 0.052). There was a significant difference in the memory domain between the control and treatment groups (p = 0.01) as measured using MoCA-INA questionnaire.

CONCLUSION: Balinese traditional flute composition was proven to be non-inferior when compared with Western classical composition as it improved mainly memory domain accompanied by increasing BDNF and decreased IL-6 levels.

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References

Salimpoor VN, Benovoy M, Larcher K, Dagher A, Zatorre RJ. Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nat Neurosci. 2011;14(2):257-62. https://doi.org/10.1038/nn.2726 PMid:21217764

Yamasaki A, Booker A, Kapur V, Tilt A, Niess H, Lillemoe KD, et al. The impact of music on metabolism. Nutrition. 2012;28(11- 12):1075-80. https://doi.org/10.1016/j.nut.2012.01.020 PMid:22858194

Gangrade A. The effect of music on the production of neurotransmitters, hormones, cytokines, and peptides: A review. Music Med. 2012;4(1):40-3. https://doi. org/10.1177/1943862111415117

Foster NA, Valentine ER. The effect of auditory stimulation on autobiographical recall in dementia. Exp Aging Res. 2001;27(3):215-28. https://doi. org/10.1080/036107301300208664 PMid:11441644

Calabrese F, Rossetti AC, Racagni G, Gass P, Riva MA, Molteni R. Brain-derived neurotrophic factor: A bridge between inflammation and neuroplasticity. Front Cell Neurosci. 2014;8:430. https://doi.org/10.3389/fncel.2014.00430 PMid:25565964

Fukui H, Yamashita M. The effects of music and visual stress on testosterone and cortisol in men and women. Neuro Endocrinol Lett. 2003;24(3-4):173-80.

Koyama M, Wachi M, Utsuyama M, Bittman B, Hirokawa K, Kitagawa M. Recreational music-making modulates immunological responses and mood states in older adults. J Med Dent Sci. 2009;56(2):79-90. PMid:20099470

Soni A. Harumkan Indonesia Dengan Music Tradisional. Kompasiana; 2013.

Joseph A, Ulrich R. Sound Control for Improved Outcomes in Healthcare Settings, Report. The Center for Health Design; 2007.

Bherer L. Cognitive plasticity in older adults: Effects of cognitive training and physical exercise. Ann N Y Acad Sci. 2015;1337:1-6. https://doi.org/10.1111/nyas.12682 PMid:2577361

Wan CY, Schlaug G. Music making as a tool for promoting brain plasticity across the life span. Neuroscientist. 2010;16(5):566-77. https://doi.org/10.1177/1073858410377805 PMid:20889966

Baird A, Samson S. Music and dementia. Prog Brain Res. 2015;217:207-35. PMid:25725917

Irish M, Cunningham CJ, Walsh JB, Coakley D, Lawlor BA, Robertson IH, et al. Investigating the enhancing effect of music on autobiographical memory in mild Alzheimer’s disease. Dement Geriatr Cogn Disord. 2006;22(1):108-20. https://doi. org/10.1159/000093487 PMid:16717466

Sung HC, Chang AM, Lee WL. A preferred music listening intervention to reduce anxiety in older adults with dementia in nursing homes. J Clin Nurs. 2010;19(7-8):1056-64. https://doi. org/10.1111/j.1365-2702.2009.03016.x PMid:20492050

Chanda ML, Levitin DJ. The neurochemistry of music. Trends Cogn Sci. 2013;17(4):179-93. PMid:23541122

Palisson J, Roussel-Baclet C, Maillet D, Belin C, Ankri J, Narme P. Music enhances verbal episodic memory in Alzheimer’s disease. J Clin Exp Neuropsychol. 2015;37(5):503-17. https:// doi.org/10.1080/13803395.2015.1026802 PMid:25951905

Dege F, Kerkovius K. The effects of drumming on working memory in older adults. Ann N Y Acad Sci. 2018;4:13685. https://doi.org/10.1111/nyas.13685 PMid:29727035

Mammarella N, Fairfield B, Cornoldi C. Does music enhance cognitive performance in healthy older adults? The Vivaldi effect. Aging Clin Exp Res. 2007;19(5):394-9. https://doi.org/10.1007/ bf03324720 PMid:18007118

Marzban M, Shahbazi A, Tondar M, Soleimani M, Bakhshayesh M, Moshkforoush A, et al. Effect of mozart music on hippocampal content of BDNF in postnatal rats. Basic Clin Neurosci J. 2011;2(3):21-6.

Noble EE, Billington CJ, Kotz CM, Wang C. The lighter side of BDNF. Am J Physiol Regul Integr Comp Physiol. 2011;300(5):R1053-69. PMid:21346243

Chung JT. Kajian Akustik Suling Bali Dalam Gambelan Kebyar (Tesis), Program Pasca Sarjana Institut Seni Indonesia Bali. Bali: Institut Seni Indonesia Bali; 2015. https://doi.org/10.31091/ mudra.v34i3.794

Chan KL, Tong KY, Yip SP. Relationship of serum brain-derived neurotrophic factor (BDNF) and health-related lifestyle in healthy human subjects. Neurosci Lett. 2008;447(2-3):124-8. https://doi.org/10.1016/j.neulet.2008.10.013 PMid:18852019

Currie J, Ramsbottom R, Ludlow H, Nevill A, Gilder M. Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women. Neurosci Lett. 2009;451(2):152-5. https://doi.org/10.1016/j. neulet.2008.12.043 PMid:19133315

Bus BA, Molendijk ML, Penninx BJ, Buitelaar JK, Kenis G, Prickaerts J, et al. Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinology. 2011;36(2):228-39. https:// doi.org/10.1016/j.psyneuen.2010.07.013 PMid:20702043

Conrad C, Niess H, Jauch KW, Bruns CJ, Hartl W, Welker L. Overture for growth hormone: Requiem for interleukin-6? Crit Care Med. 2007;35(12):2709-13. https://doi.org/10.1097/01. ccm.0000291648.99043.b9 PMid:18074473

Fancourt D, Perkins R, Ascenso S, Carvalho LA, Steptoe A, Williamon A. Effects of group drumming interventions on anxiety, depression, social resilience and inflammatory immune response among mental health service users. PLoS One. 2016;11(3):e0151136. https://doi.org/10.1371/journal. pone.0151136 PMid:26974430

Siejka A, Stepien T, Lawnicka H, Krupinski R, Komorowski J, Stepien H. Effect of the growth hormone-releasing hormone [GHRH(1-44)NH2] on IL-6 and IL-8 secretion from human peripheral blood mononuclear cells in vitro. Endocr Regul. 2005;39(1):7-11. https://doi.org/10.1016/j.npep.2003.12.001 PMid:16107133