Profile of Daily Life in Children with Brain Tumors: An Assessment of PedsQL 4.0 Generic Core Scales before and after Treatment

Julius July; Natasha Bastiaan; Steven Tandean; Michael Lumintang Loe

doi:10.3889/oamjms.2020.4529

Authors

Julius July Department of Neurosurgery, Faculty of Medical, Universitas Pelita Harapan, Neuroscience Centre of Siloam Hospital, Lippo Village, Tangerang, Indonesia; Mochtar Riady Institute for Nanotechnology and Medical Science Group, Universitas Pelita Harapan, Lippo Village, Tangerang, Indonesia
Natasha Bastiaan Department of Neurosurgery, Faculty of Medical, Universitas Pelita Harapan, Neuroscience Centre of Siloam Hospital, Lippo Village, Tangerang, Indonesia
Steven Tandean Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara/ Haji Adam Malik General Hospital, Medan 20155, Indonesia
Michael Lumintang Loe Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara/ Haji Adam Malik General Hospital, Medan 20155, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4529

Keywords:

brain tumor, quality of life, peds-ql 4.0 generic core scales

Abstract

BACKGROUND: Pediatric brain tumors are the most common solid tumor and cause of death among all childhood cancers. In America, brain tumor prevalence is 21.42/100.000 population. Even though survival rate is improving, the impact of treatment for long-term quality of life is still a challenge.

AIM: We aimed to investigate quality of life score using PedsQL 4.0 Generic Core Scales.

METHODS: The data collected based on the inclusion criteria from patient’s medical records 2015–2017 period on January 2018–May 2018 in Siloam Hospital, Lippo Village, Karawaci. Twenty-six brain tumor pediatric patients with surgical treatment were evaluated using PedsQL 4.0 Generic Core Scales. The evaluation included before and after condition of the patient. PedsQL 4.0 Generic Core Scales were divided into four categories; physical function, emotional function, social function, and school function. They were analyzed statically using Wilcoxon test with p < 0.05 considered as statistically significant.

RESULTS: The result showed that before treatment score of PedsQL 4.0 Generic Core Scales was classified as medium functioning (58.54/92) and after treatment score of PedsQL 4.0 Generic Core Scales was classified as intermediate functioning (37.3/92).

CONCLUSION: The conclusion is that patient after treatment (surgery, chemotherapy, and radiation) shows improved quality of life score using PedsQL 4.0 Generic Core Scales.

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References

Crawford J. Childhood Brain Tumors. Pediatr Rev. 2013;34(2):63-77.

Bhat SR, Goodwin TL, Burwinkle TM, Lansdale MF, Dahl GV, Huhn SL, et al. Profile of daily life in children with brain tumors: An assessment of health-related quality of life. J Clin Oncol. 2005;23(24):5493-500. https://doi.org/10.1200/jco.2005.10.190 PMid:16110009

Loonen HJ, Derkx BH, Otley AR. Measuring health- related quality of life of pediatric patients. J Pediatr Gastroenterol Nutr. 2001;32(5):523-26. https://doi. org/10.1097/00005176-200105000-00006 PMid:11429510

Kun LE, Mulhern RK, Crisco JJ. Quality of life in children treated for brain tumors. J Neurosurg. 1983;58:1-6. https://doi. org/10.3171/jns.1983.58.1.0001

Child Self-Report (CHQ-CF87). In: Michalos AC, editors. Encyclopedia of Quality of Life and Well- Being Research. Dordrecht: Springer; 2014. https://doi. org/10.1007/978-94-007-0753-5_100468

Varni JW, Burwinkle TM, Seid M, Skarr D. The PedsQL 4.0 as a pediatric population health measure: Feasibility, reliability, and validity. Ambul Pediatr. 2003;3(6):329-41. https://doi. org/10.1367/1539-4409(2003)003<0329:tpaapp>2.0.co;2 PMid:14616041

Kim CW, Joo JD, Kim YH, Han JH, Kim CY. Health-related quality of life in brain tumor patients treated with surgery: Preliminary result of a single institution. Brain Tumor Res Treat. 2016;4(2):87-93. https://doi.org/10.14791/btrt.2016.4.2.87 PMid:27867917

Kuhlthau KA, Pulsifer MB, Yeap BY, Rivera MD, Delahaye J, Hill KS, et al. Prospective study of health-related quality of life for children with brain tumors treated with proton radiotherapy. J Clin Oncol. 2012;30(17):2079-86. https://doi.org/10.1200/ jco.2011.37.0577 PMid:22565004

Singh O, Meena RN, Srivastava V, Pandey V, Shah AG, Meena RK. Impact of brain tumour treatment on quality of life in children: A health perspective. Neurooncol Open Access. 2016;1:1.

Macartney G, VanDenKerkhof E, Harrison MB, Stacey D. Symptom experience and quality of life in pediatric brain tumor survivors: A cross-sectional study. J Pain Symptom Manage. 2014;48(5):957-67. https://doi.org/10.1016/j. jpainsymman.2013.12.243 PMid:24704799

Collins JJ, Byrnes ME, Dunkel IJ, Lapin J, Nadel T, Thaler HT, et al. The measurement of symptoms in children with cancer. J Pain Symptom Manage. 2000;19(5):363-77. https://doi. org/10.1016/s0885-3924(00)00127-5 PMid:10869877

Gupta P, Jalali R. Long-term survivors of childhood brain tumor: Impact on general health and quality of time. Curr Neurol Neurosci Rep. 2017;17(12):99. https://doi.org/10.1007/ s11910-017-0808-0

Gunn ME, Lähdesmäki T, Malila N, Arola M, Grönroos M, Matomäki J, et al. Late morbidity in long-term survivors of childhood brain tumors: A nationwide registry-based study in Finland. Neuro Oncol. 2015;17(5):747-56. https://doi. org/10.1093/neuonc/nou321 PMid:25422316