Effects of Moringa Oleifera Leaves and Honey Supplementation during Pregnancy on Mothers and Newborns: A Review of the Current Evidence

Authors

  • Veni Hadju School of Public Health, Hasanuddin University, Makassar, Indonesia
  • Muhammad Dassir School of Forestry, Hasanuddin University, Makassar, Indonesia
  • Andi Sadapotto School of Forestry, Hasanuddin University, Makassar, Indonesia
  • Aliyah Putranto School of Pharmacy, Hasanuddin University, Makassar, Indonesia
  • Geoffrey Marks School of Public Health, University of Queensland, Brisbane, Australia
  • Andi Imam Arundhana School of Public Health, Hasanuddin University, Makassar, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4670

Keywords:

pregnant women, Moringa oleifera, honey, newborn, supplementation

Abstract

BACKGROUND: Malnutrition in pregnant women has been known to bring effects on the mothers’ and infants’ health. Food or nutrient supplementation is now being used to correct the problems. Moringa Oleifera leaves and honey are the two types of natural supplements used by pregnant women.

AIM: This systematic review aimed to evaluate the potential effects of Moringa, honey, and both compared to ironfolic acid supplements given to pregnant women on the pregnancy outcomes.

METHODS: A systematic review was conducted to evaluate the extent of the benefits of the supplementation of M. Oleifera, honey, or both against pregnant women. There were seven studies which are conducted in Indonesia on this topic.

RESULTS: This review shows that M. Oleifera leaves in the form of extract and powder as well as honey could improve maternal weight and hemoglobin, and baby’s birth weight. Moreover, both interventions could reduce stress and protect mothers and their babies from negative effects of oxidative stress.

CONCLUSION: Nevertheless, efforts are needed to formulate a recommended dose as adequate supplements for pregnant women.

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References

Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, et al. Maternal and child undernutrition: Global and regional exposures and health consequences. Lancet. 2008;371(9608):243-60. https://doi.org/10.1016/ s0140-6736(07)61690-0 PMid:18207566

Sloan NL, Lederman SA, Leighton J, Himes JH, Rush D. The effect of prenatal dietary protein intake on birth weight. Nutr Res. 2001;21(1):129-39. https://doi.org/10.1016/ s0271-5317(00)00258-x

dos Santos Q, Sichieri R, Marchioni DM, Junior EV. Brazilian pregnant and lactating women do not change their food intake to meet nutritional goals. BMC Pregnancy Childbirth. 2014;14(1):186. https://doi.org/10.1186/1471-2393-14-186 PMid:24890188

Lindsay KL, Buss C, Wadhwa PD, Entringer S. The interplay between nutrition and stress in pregnancy: Implications for fetal programming of brain development. Biol Psychiatry. 2019;85(2):135-49. https://doi.org/10.1016/j. biopsych.2018.06.021 PMid:30057177

Entringer S, Buss C, Wadhwa PD. Prenatal stress, development, health and disease risk: A psychobiological perspective-2015 curt richter award paper. Psychoneuroendocrinology. 2015;62:366- 75. https://doi.org/10.1016/j.psyneuen.2015.08.019 PMid:26372770

Walker J, Littlewood R. Pragmatic implementation studies to improve nutrition practices and policies: Childcare during the first 1000 days as a contributor to long-term health. Public Health Nutr. 2018;21(7):1209-11. https://doi.org/10.1017/ s1368980018000022 PMid:29642971

Sampeangin H, Thaha AR, Hadju V, Sirajuddin S, Malongi A. Effectiveness of PMT supplement biscuit to hemoglobin content of pregnant woman in Parepare city. Int J Sci Basic Appl Res. 2017;36(6):156-64.

Haider BA, Yakoob MY, Bhutta ZA. Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes. BMC Public Health. 2011;11 Suppl 3:S19. https://doi.org/10.1186/1471-2458-11-s3-s19 PMid:21501436

Vongsak B, Sithisarn P, Mangmool S, Thongpraditchote S, Wongkrajang Y, Gritsanapan W. Maximizing total phenolics, total flavonoids contents and antioxidant activity of Moringa oleifera leaf extract by the appropriate extraction method. Ind Crops Prod. 2013;44:566-71. https://doi.org/10.1016/j. indcrop.2012.09.021

Leone A, Spada A, Battezzati A, Schiraldi A, Aristil J, Bertoli S. Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera Leaves: An overview. Int J Mol Sci. 2015;16(6):12791-835. https://doi.org/10.3390/ ijms160612791

Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, propolis, and royal jelly: A comprehensive review of their biological actions and health benefits. Oxid Med Cell Longev. 2017;2017:1259510. https://doi.org/10.1155/2017/1259510 PMid:28814983

Islam MR, Pervin T, Hossain H, Saha B, Hossain SJ. Physicochemical and antioxidant properties of honeys from the sundarbans mangrove forest of Bangladesh. Prev Nutr Food Sci. 2017;22(4):335-44. https://doi.org/10.3746/pnf.2017.22.4.335 PMid:29333387

Choi JY. Complementary therapy for improvement of quality of life in cancer patients. J Korean Med Assoc. 2008;51(5):435-48.

Alam F, Islam MA, Gan SH, Khalil MI. Honey: A potential therapeutic agent for managing diabetic wounds. Evid Based Complement Alternat Med. 2014;2014:169130. PMid:25386217

Otoluwa A, Salam A, Syauki Y, Nurhasan M, Monoarfa Y, As’ad S, et al. Effect of Moringa oleifera Leaf extracts supplementation in preventing maternal DNA damage. Int J Sci Res Publ. 2014;4(11):1-4.

Iskandar I, Hadju V, As’ad S, Natsir R. Effect of Moringa Oleifera Leaf extracts supplementation in preventing maternal anemia and low birth weight. Int J Sci Res Publ. 2015;5(2):1-3.

Muis M, Hadju V, Russeng S, Naiem MF. Effect of Moringa Leaves extract on occupational stress and nutritional status of pregnant women informal sector workers. Int J Curr Res Acad Rev. 2014;2(11):86-92.

Hermansyah H, Hadju V, Bahar B. Moringa Leaves extract on food intake and weight gain of pregnant women working in informal sector. J Ilmu Kesehatan Masyarakat. 2014;5(3):192-201.

Nadimin, Hadju V, As’ad S, Buchari A. The extract of Moringa Leaf has an equivalent effect to iron folic acid in increasing hemoglobin levels of pregnant women: A randomized control study in the coastal area of Makassar. Int J Sci Basic Appl Res. 2015;22(1):287-94. https://doi. org/10.5958/0976-5506.2019.00102.5

Khuzaimah A, Hadju V, As’ad S, Abdullah N, Burhanuddin B, Riu D. Effect of honey and Moringa oleifera Leaf extracts supplementation for preventing DNA damage in passive smoking pregranancy. Int J Sci Basic Appl Res. 2015;23(1):138-45.

Nurdin MS, Hadju V, Zulkifli A, Arundhana AI. The effect of Moringa Leaf extract and powder to haemoglobin concentration among pregnant women in Jeneponto regency. Indian J Public Health Res Dev. 2018;9(2):262-7. https://doi. org/10.5958/0976-5506.2018.00130.4

Arundhana AI, Nurdin MS, Hadju V, Ansariadi A, Zulkifli AJ. The effect of Moringa-based supplementation on fetal birth weight in Jeneponto regency. J Pharm Nutr Sci. 2018;8(3):144-9. https:// doi.org/10.6000/1927-5951.2018.08.03.9

Hafid RA. Effect of Moringa oleifera Leaf Powder in Pregnant Women on Brith Weight. Makassar: Midwifery Program, Hasanuddin University; 2018.

Hasni. The Effect of Moringa oleifera Leaf Powder in Pregnant Women on Stress and Salivary Cortisol Level. Makassar: Midwifery Program, Hasanuddin University; 2018.

Yusnidar. The Effect of Moringa oleifera Leaf Powder in Pregnant Women on Hemoglobin. Makassar: Midwifery Program, Hasanuddin University; 2018.

Ningsih S. The Effect of Moringa oleifera Leaf Powder Supplementation in Pregnant Women on Maternal Stress and Birthweight. Makassar: Midwife Program, Hasanuddin University; 2018.

Rini AS. The Effect of Moringa oleifera Leaf Powder in Pregnant Women On Maternal Malondialdehyde and Brith Weight. Makassar: Midwifery Program, Hasanuddin University; 2018.

Valdez-Solana MA, Mejía-García VY, Téllez-Valencia A, García-Arenas G, Salas-Pacheco J, Alba-Romero JJ, et al. Nutritional content and elemental and phytochemical analyses of grown in Moringa oleifera Mexico. J Chem. 2015;2015:860381. https://doi.org/10.1155/2015/860381

Gopalakhrisnan L, Doriya K, Kumar DS. Moringa oleifera: A review on nutritive importance and its medicinal application. Food Sci Hum Wellness. 2016;5(2):49-56. https://doi. org/10.1016/j.fshw.2016.04.001

Saini RK, Manoj P, Shetty NP, Srinivasan K, Giridhar P. Dietary iron supplements and Moringa oleifera Leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats. Nutr Res. 2014;34(7):630-8. https:// doi.org/10.1016/j.nutres.2014.07.003 PMid:25150122

Stewart CP, Oaks BM, Laugero KD, Ashorn U, Harjunmaa U, Kumwenda C, et al. Maternal cortisol and stress are associated with birth outcomes, but are not affected by lipidbased nutrient supplements during pregnancy: An analysis of data from a randomized controlled trial in rural Malawi. BMC Pregnancy Childbirth. 2015;15(1):346. https://doi.org/10.1186/ s12884-015-0793-8 PMid:26694646

Lindsay KL, Buss C, Wadhwa PD, Entringer S. The interplay between maternal nutrition and stress during pregnancy: Issues and considerations. Ann Nutr Metab. 2017;70(3):191-200. https://doi.org/10.1159/000457136 PMid:28301838

Weinstock M. The potential influence of maternal stress hormones on development and mental health of the offspring. Brain Behav Immun. 2005;19(4):296-308. https://doi. org/10.1016/j.bbi.2004.09.006 PMid:15944068

Mulder EJ, Robles de Medina PG, Huizink AC, van den BerghBR, Buitelaar JK, Visser GH. Prenatal maternal stress: Effects on pregnancy and the (unborn) child. Early Hum Dev. 2002;70(1- 2):3-14. https://doi.org/10.1016/s0378-3782(02)00075-0 PMid:12441200

Rasmussen KM, Stoltzfus RJ. New evidence that iron supplementation during pregnancy improves birth weight: New scientific questions. Am J Clin Nutr. 2003;78(4):673-4. https:// doi.org/10.1093/ajcn/78.4.673 PMid:14522723

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Published

2020-09-20

How to Cite

1.
Hadju V, Dassir M, Sadapotto A, Putranto A, Marks G, Arundhana AI. Effects of Moringa Oleifera Leaves and Honey Supplementation during Pregnancy on Mothers and Newborns: A Review of the Current Evidence. Open Access Maced J Med Sci [Internet]. 2020 Sep. 20 [cited 2021 Dec. 4];8(F):208-14. Available from: https://oamjms.eu/index.php/mjms/article/view/4670

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