The Stromal Cell-derived Factor-1/CXCL12 3’A-gene Polymorphism is Related to the Increased Risk of Coronary Artery Disease: A Systematic Review and Meta-analysis
DOI:
https://doi.org/10.3889/oamjms.2020.4724Keywords:
SDF-1, CXCL-12, Polymorphism, coronary artery disease, geneAbstract
BACKGROUND: Single-nucleotide polymorphism in the stromal cell-derived factor-1 (SDF-1)/CXCL12 gene had been associated with an increased risk of coronary artery disease (CAD). However, several published studies have shown inconsistent results.
AIM: A meta-analysis was assessed to evaluate the association between SDF-1 3’A-gene polymorphism and CAD in the literature.
METHODS: A systematic review was conducted in accordance with PRISMA guidelines and adhering to the Cochrane Handbook for Systematic Reviews. The literature search strategy was carried out on April 3, 2019, from PubMed, EBSCO, Google Scholar, and DOAJ during 2013–2018 period using various keywords related to SDF-1, CXCL12, polymorphism, and CAD. Original data from the group, case-control study, English full-text, and DNA polymorphism assessment using polymerase chain reaction were enrolled. Gene polymorphism in A-base nucleotide among patients with CAD and healthy subjects were evaluated. All data were analyzed using Review Manager 5.3 (Cochrane, Denmark) for meta-analysis.
RESULTS: Five eligible studies extracted for data analysis (2013–2018) based on the assessment of 2-independent reviewers. Several studies have been excluded due to irrelevant criteria evaluated. A significant result was found between SDF-1 3’A gene polymorphism with the increased risk of CAD in the overall effect evaluation using a fixed-effects model (odds ratio [OR]: 2.02; 95% confidence interval 1.54-2.65; I2: 34%; p<0.001) on the forest plot.
CONCLUSION: Our meta-analysis suggests that gene polymorphism in A-base nucleotide of SDF-1/CXCL-12 was associated with the susceptibility of CAD. However, a bigger-scale and well-design of case-control study should be conducted to clarify these conclusions.
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GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the global burden of disease study 2013. Lancet. 2015;385(9963):117-71. https://doi.org/10.1016/s0140-6736(14)61682-2 PMid:25530442
Álvarez-Álvarez MM, Zanetti D, Carreras-Torres R, Moral P, Athanasiadis G. A survey of Sub-3.Saharan gene flow into the Mediterranean at risk loci for coronary artery disease. Eur J Hum Genet. 2017;25(4):472-6. https://doi.org/10.1038/ejhg.2016.200 PMid:28098150
Ross R, Glomset J, Harker L. Response to injury and atherogenesis. Am J Pathol. 1977;86(3):675-84. PMid:842616
Tedgui A, Mallat Z. Cytokines in atherosclerosis: Pathogenic and regulatory pathways. Physiol Rev. 2006;86(2):515-81. https://doi.org/10.1152/physrev.00024.2005 PMid:16601268
Alam SE, Nasser SS, Fernainy KE, Habib AA, Badr KF. Cytokine imbalance in acute coronary syndrome. Curr Opin Pharmacol. 2004;4(2):166-70. PMid:15063361
Farouk SS, Rader DJ, Reilly MP, Mehta NN. CXCL12: A new player in coronary disease identified through human genetics. Trends Cardiovasc Med. 2010;20(6):204-9. https://doi.org/10.1016/j.tcm.2011.08.002 PMid:22137643
Akhtar S, Gremse F, Kiessling F, Weber C, Schober A. CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in apoe-deficient mice. Arterioscler Thromb Vasc Biol. 2013;33(4):679-86 https://doi.org/10.1161/atvbaha.112.301162 PMid:23393393
Teicher BA, Fricker SP. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res. 2010;16(11):2927-31. https://doi.org/10.1158/1078-0432.ccr-09-2329 PMid:20484021
Melamed KH, Goldhaber SZ. Cardiology patient page: Inflammation and myocardial infarction. Circulation. 2014;130(24):e334-6. PMid:25602951
Subramanian S, Liu C, Aviv A, Ho JE, Courchesne P, Muntendam P, et al. Stromal cell-derived factor 1 as a biomarker of heart failure and mortality risk. Arterioscler Thromb Vasc Biol. 2014;34(9):2100-5. https://doi.org/10.1161/atvbaha.114.303579 PMid:25060794
Feng L, Nian SY, Hao YL, Xu WB, Zhang XF, Li D, et al. A single nucleotide polymorphism in the stromal cellderived factor 1 gene is associated with coronary heart disease in Chinese patients. Int J Mol Sci. 2014;15(6):11054-63. https://doi.org/10.3390/ijms150611054 PMid:24950177
Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B. Genomewide association analysis of coronary artery disease. New Engl J Med. 2007;357(5):443-53. PMid:17634449
Szalai C, Duba J, Prohászka Z, Kalina A, Szabó T, Nagy B, et al. Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1-2518 G/G genotype in CAD patients. Atherosclerosis. 2001;158(1):233-9. https://doi.org/10.1016/s0021-9150(01)00423-3 PMid:11500196
Eba A, Raza ST, Abbas M, Rizvi S, Rajput M, Mahdi F. Association of SDF1β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease. Br J Biomed Sci. 2019;76(1):49-51. https://doi.org/10.1080/09674845.2018.1527802 PMid:30253706
Mansoori Y, Daraei A, Zendebad Z, Madadizadeh F, Mansoori B, Naghizadeh MM, et al. The SDF1 A/G gene variant: A susceptibility variant for myocardial infarction. Genet Test Mol Biomarkers. 2017;21(8):506-11. https://doi.org/10.1089/gtmb.2017.0023 PMid:28650670
Gu XL, Ma N, Xiang DC, Huang J, Dong ZH, Lei HY, et al. Polymorphism of stromal cell-derived factor 1 selectively upregulates gene expression and is associated with increased susceptibility to coronary artery disease. Biochem Biophys Res Commun. 2014;443(3):932-7. https://doi.org/10.1016/j.bbrc.2013.12.065 Mid:24361877
Borghini A, Sbrana S, Vecoli C, Mercuri A, Turchi S, Carpeggiani C, et al. Stromal cell-derived factor-1-3’A polymorphism is associated with decreased risk of myocardial infarction and early endothelial disturbance. J Cardiovasc Med (Hagerstown). 2014;15(9):710-6. https://doi.org/10.2459/jcm.0000000000000068 PMid:24751515
Zhang J, Ma H, Gao J, Kong S, You J, Sheng Y. Variants in the CXCL12 gene was associated with coronary artery disease susceptibility in Chinese Han population. Oncotarget. 2017;8(33):54518-27. https://doi.org/10.18632/oncotarget.17171 PMid:28903360
Wu N, Zhang X, Jia P, Jia D. Lack of an association between the SDF-1 rs1801157 polymorphism and coronary heart disease: A meta-analysis. Sci Rep. 2015;5:11803. https://doi.org/10.1038/srep11803
van der Vorst EP, Doring Y, Weber C. MIF and CXCL12 in cardiovascular diseases: Functional differences and similarities. Front Immunol. 2015;6:373. https://doi.org/10.3389/fimmu.2015.00373 PMid:26257740
Luan B, Han Y, Zhang X, Kang J, Yan C. Association of the SDF1-3’A polymorphism with susceptibility to myocardial infarction in Chinese Han population. Mol Biol Rep. 2010;37(1):399-403. https://doi.org/10.1007/s11033-009-9845-3 PMid:19821058
Damås JK, Waehre T, Yndestad A, Ueland T, Müller F, Eiken HG, et al. Stromal cell-derived factor-1alpha in unstableangina: Potential antiinflammatory and matrix-stabilizing effects. Circulation. 2002;106(1):36-42. https://doi.org/10.1161/01.cir.0000020001.09990.90 PMid:12093767
Rath D, Chatterjee M, Borst O, Müller K, Stellos K, Mack AF, et al. Expression of stromal cell-derived factor-1 receptors CXCR4 and CXCR7 on circulating platelets of patients with acute coronary syndrome and association with left ventricular functional recovery. Eur Heart J. 2014;35:386-94. https://doi.org/10.1093/eurheartj/eht448 PMid:24168792
Xiao Q, Ye S, Oberhollenzer F, Mayr A, Jahangiri M, Willeit J, et al. SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: The Bruneck study. PLoS One. 2008;3(12):e4061. https://doi.org/10.1371/journal.pone.0004061 PMid:19115008
Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med. 1997;185:111-20. https://doi.org/10.1084/jem.185.1.111 PMid:8996247
Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964-7. https://doi.org/10.1126/science.275.5302.964 PMid:9020076
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Copyright (c) 2020 I Putu Yuda Prabawa, Anak Agung Wiradewi Lestari, I Made Muliarta, Putu Eka Mardhika, Gusti Ayu Riska Pertiwi, Agha Bhargah, Ida Bagus Amertha Putra Manuaba, Made Junior Rina Artha, I Ketut Rina, Starry Homenta Rampengan (Author)
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