The Analysis of Binahong Leaves Potential (Anredera cordifolia) as an Alternative Treatment of Anticataractogenesis

Authors

  • Feriyani Feriyani Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, Indonesia; Faculty of Medicine Universitas Abulyatama
  • Darmawi Darmawi Laboratory of Research, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, Indonesia; Laboratory of Microbiology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, Indonesia
  • Ummu Balqis Laboratory of Pathology, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, Indonesia
  • Rodiah Rahmawaty Lubis Department of Ophthalmology, Faculty of Medicine, Universitas Sumatera Utara, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4849

Keywords:

Binahong leaves, Alternative treatment, Cataractogenesis

Abstract

BACKGROUND: Cataract is a condition where the retina cannot capture images completely and causes blindness due to an imbalance of reactive oxygen species (ROS). These free radicals can be suppressed using antioxidants from several plants, one of which is binahong leaves.

AIM: The purpose of this study is to analyze the potential of binahong leaves as an initial screening that can play a role in inhibiting the process of cataractogenesis.

METHODS: By extracting binahong leaves with 60% ethanol, the extracts were tested for phytochemistry using the X technique and GC–MS using the Perkin-Elmer GC Clarus 500. The experimental process and all laboratory analyses were fully carried out from June to December 2019 at the Laboratory of Food Analysis and Yield Agriculture, Department of Agricultural Product Technology, Syiah Kuala University, Banda Aceh.

RESULTS: Analysis of binahong leaf potential showed that binahong leaves contain flavonoids, steroids, phenols, alcoholics, terpenoids, and saponins. While the GC–MS analysis results showed that binahong leaves are rich in phytol and contain fatty acids.

CONCLUSION: Binahong leaves have the potential to be anticataractogenesis because they contain compounds rich in antioxidants.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Flaxman SR, Bourne RR, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, et al. Global causes of blindness and distance vision impairment 1990-2020: A systematic review and meta-analysis. Lancet Glob Health. 2017;5(12):e1221-34. PMid:29032195

WHO Media Centre. Vision Impairment and Blindness. Geneva: World Health Organization; 2018.

Ottonello S, Foroni C, Carta A, Petrucco S, Maraini G. Oxidative stress and age-related cataract. Ophthalmologica. 2000; 214(1):78-85. https://doi.org/10.1159/000027474 PMid:10657746

Truscott RJ. Age-related nuclear cataract-oxidation is the key. Exp Eye Res. 2005;80(5):709-25. https://doi.org/10.1016/j. exer.2004.12.007 PMid:15862178.

Ho MC, Peng YJ, Chen SJ, Chiou SH. Senile cataracts and oxidative stress. J Clin Gerontol Geriatr. 2010;1(1):17-21.

Dillon J. UV-B as a pro-aging and pro-cataract factor. Doc Ophthalmol. 1995;88(3-4):339-44. https://doi.org/10.1007/ bf01203686 PMid:7635001

Nagy ZZ. New technology update: Femtosecond laser in cataract surgery. Clin Ophthalmol. 2014;8:1157-67. PMid:24970994

De la Fuente JÁ, Manzanaro S, Martín MJ, de Quesada TG, Reymundo I, Luengo SM, et al. Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product. J Med Chem. 2003;46(24):5208-21. https://doi.org/10.1021/jm030957n PMid:14613323

Tewari D, Samoilă O, Gocan D, Mocan A, Moldovan C, Devkota HP, et al. Medicinal plants and natural products used in cataract management. Front Pharmacol. 2019;10:466. https:// doi.org/10.3389/fphar.2019.00466 PMid:31263410

Kaur A, Gupta V, Christopher AF, Malik MA, Bansal P. Nutraceuticals in prevention of cataract-an evidence based approach. Saudi J Ophthalmol. 2017;31(1):30-7. https://doi. org/10.1016/j.sjopt.2016.12.001 PMid:28337060

Julien M, McFadyen RE, Cullen J. Biological Control of Weeds in Australia. Australia: Csiro Publishing; 2012. p. 60-4. https:// doi.org/10.1071/9780643104204

Wang T, Zhang P, Zhao C, Zhang Y, Liu H, Hu L, et al. Prevention effect in selenite-induced cataract in vivo and antioxidative effects in vitro of Crataegus pinnatifida leaves. Biol Trace Elem Res. 2011;142(1):106-16. https://doi.org/10.1007/ s12011-010-8752-8 PMid:20596791

Rooban BN, Sasikala V, Devi VG, Sahasranamam V, Abraham A. Prevention of selenite induced oxidative stress and cataractogenesis by luteolin isolated from Vitex negundo. Chem Biol Interact. 2012;196(1-2):30-8. https://doi.org/10.1016/j. cbi.2012.01.005 PMid:22342831

Selawa W, Runtuwene MR, Citraningtyas GH. Flavonoid content and total antioxidant capacity of binahong leaf ethanol extract Anredera cordifolia (ten.) steenis. Pharmacon J. 2013;2(1):18-23. https://doi.org/10.18860/al.v0i1.2917

Fidrianny I, Wirasutisna KR, Amanda P. Senyawa antioksidan dari ekstrak etil asetat daun binahong (Anredera cordifolia (Ten.) Steenis) dari babakan ciparay, Bandung Selatan, Indonesia. Acta Pharm Indones. 2013;38(1):26-30. https://doi. org/10.32382/mf.v15i2.1127

Amertha, IB, Soeliongan S, Kountul C. In vitro inhibition zone test of binahong (Anredera cordifolia) towards Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. Indones J Biomed Sci. 2012;6(1):30-4.

Astuti, SM, M Sakinah, R Andayani, Risch A. Determination of saponin compound from Anredera cordifolia (Ten) Steenis plant (binahong) to potential treatment for several diseases. J Agric Sci. 2011;3(4):224-32. https://doi.org/10.5539/jas.v3n4p224

Nazaruk J, Borzym-Kluczyk M. The role of triterpenes in the management of diabetes mellitus and its complications. Phytochem Rev. 2015;14(4):675-90. https://doi.org/10.1007/ s11101-014-9369-x PMid:26213526

Xiang M, Wang J, Zhang Y, Ling J, Xu X. Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFκB pathway in streptozocin-induced diabetic rats. Arch Pharm Res. 2012;35(5):877-86. https://doi.org/10.1007/s12272-012-0513-0 PMid:22644855

Santos CC, Salvadori MS, Mota VG, Costa LM, de Almeida AA, de Oliveira GA, et al. Antinociceptive and antioxidant activities of phytol in vivo and in vitro models. Neurosci J. 2013;2013:949452. PMid:26317107

Islam MT, Ali ES, Uddin SJ, Shaw S, Islam MA, Ahmed MI, et al. Phytol: A review of biomedical activities. Food Chem Toxicol. 2018;121:82-94. PMid:30130593

Asha R, Devi VG, Abraham A. Lupeol, a pentacyclic triterpenoid isolated from Vernonia cinerea attenuate selenite induced cataract formation in Sprague Dawley rat pups. Chem Biol Interact. 2016;245:20-9. https://doi.org/10.1016/j. cbi.2015.12.002 PMid:26697995

Downloads

Published

2020-08-20

How to Cite

1.
Feriyani F, Darmawi D, Balqis U, Lubis RR. The Analysis of Binahong Leaves Potential (Anredera cordifolia) as an Alternative Treatment of Anticataractogenesis. Open Access Maced J Med Sci [Internet]. 2020 Aug. 20 [cited 2024 Apr. 23];8(B):820-4. Available from: https://oamjms.eu/index.php/mjms/article/view/4849

Most read articles by the same author(s)