A Pilot Study of the Evaluation of Using Antibiotics in Sepsis Patients in Palu, Indonesia


  • Alwiyah Mukaddas Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, Indonesia
  • Tatat Rahmita Utami Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, Indonesia
  • Amelia Rumi Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, Indonesia




Heart rate, Respiration rate, Glasgow Coma, Scale, Comorbid, Sepsis


BACKGROUND: Treatment therapy with antibiotics is one of the factors supporting success in the treatment of sepsis.

AIM: This study aims to evaluate the use of antibiotics in patients with sepsis using parameters of the day of decline in body temperature, heart rate, respiration rate, changes in consciousness status, and comorbid factors.

MATERIALS AND METHODS: The design of this study is pilot study with a retrospective approach on sample of 14 sepsis patients who met the inclusion criteria. Descriptive analysis using the univariate method for see changes in levels of body temperature, length of stay, respiration rate, heart rate, comorbid factors, and changes in the consciousness status.

RESULTS: The results showed an average value for decline of body temperature after using antibiotics with a baseline of 38.47°C–37.87°C, heart rate shows the average value from baseline heart rate after using antibiotics from baseline of 110.8 bpm to 88.4 bpm, the respiration rate shows the average value for the respiration rate after using antibiotics from baseline of 30.8 x/min to 22.1 x/min, Glasgow Coma Scale (GCS) score showed an average value after using antibiotics from baseline 9 to 7, on comorbid factors showing six patients with one comorbid and eight patients with more than 1 comorbid factor.

CONCLUSION: The study concluded that body temperature is still in the category of fever, heart rate, and respiration rate which are the normal category, patient consciousness is still at the level of somnolence even though patient’s GCS score has decreased, and patients with one factor of comorbidities are faster in death because they have a fatal type of comorbid such as acute of hepatitis, coma hepaticum, and acute kidney injury.


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Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy: A Pathophysiologic Approach. 10th ed. United State: McGraw Hill; 2017.

Dellinger R, Levy MM, Rhodes A, Rhodes A, Annane D, Gerlach H, et al. Surviving sepsis campaign : International guidelines for management of severe sepsis and septic shock. Intensive Care Med. 2013;39:165-228. https://doi.org/10.1007/s00134-012-2769-8

Rhodes A, Evans L, Alhazzani W, Levy M, Antonelli M, Ferrer R, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med. 2017;45(3):486-552. https://doi.org/10.1097/ccm.0000000000000192 PMid:28098591

Seputra K, Tarmono T, Noegroho B, Mochtar C. Guideline Does The Urinary Tract Infection and Male Genitalia. 2nd ed. Surabaya: Indonesian Urological Association; 2015.

Soong J, Sony N. Sepsis: Recognition and treatment. Clin Med. 2012;12(3):276-80. PMid:22783783

Dewi SA, Pudjiaji AH, Djer MM, Supriyanto B, Syarif DR, Kurniati N. Risk Factors That Play a Role in Sepsis Mortality. Jakarta: The University of Indonesia; 2014.

Hidayati, Arifin H, Raveinal R. The Study of Antibiotic Use in Patients Sepsis with Kidney Disease. J Sains Farm Klin. 2016.

Ahmad N. The Correlation between the SOFA Score and Length of Stay Sepsis Patient at the Intensive Care Unit. Semarang: Dr. Kariadi Hospital; 2015.

Bhattacharjee P, Edelson D, Churpek MM. Identifying patients with sepsis on the hospital wards. Chest. 2017;151(4):898-907. https://doi.org/10.1016/j.chest.2016.06.020

Tambayong RN, Diana CL, Lucky K. Profile of Sepsis Patients in Dr. R. D Kandou Manado Hospital. Manado: Journal of E-Clinic; 2016.

Indonesian Intensive Care Doctor Association. The Alignment of Sepsis and Septic Shock Optimize Fasthugsbid. Jakarta: Indonesian Intensive Care Doctor Association; 2014.

Yuliarto S, Kadafi KT, Nugrahani IT, Aminingrum R, Asariati H. The barrier of surviving sepsis campaign guideline 2012 implementation for children at tertiary hospital. Malang. Brawijaya Med J. 2014;28(1):4-6. https://doi.org/10.21776/ub.jkb.2014.028.01.11

Alalawi MS, Aljabran HA, Alkhamri AM, Alwahbi AM, AlQarrash ZA, Iraqi HA, et al. Glasgow coma scale in anticipation of sepsis and septic shock. Egypt J Hosp Med. 2017;69(6):2663- 6. https://doi.org/10.12816/0042245

Leekha S. General principles of antimicrobial theraphy. Mayo Clin Proc. 2011;86(2):156-67. PMid:21282489

Apriliana W. Rational Evaluation Use of Antibiotics Prophylaxis to Acute Appendicitis Operation in Adults and Geriatric Patients at Bethesda Hospital in Yogyakarta, Thesis, School of Pharmacy. Indonesia: Sanata Dharma Univesity; 2017.




How to Cite

Mukaddas A, Utami TR, Rumi A. A Pilot Study of the Evaluation of Using Antibiotics in Sepsis Patients in Palu, Indonesia. Open Access Maced J Med Sci [Internet]. 2020 Jul. 29 [cited 2021 Jul. 31];8(B):1036-40. Available from: https://oamjms.eu/index.php/mjms/article/view/4879