A Pilot Study of the Evaluation of Using Antibiotics in Sepsis Patients in Palu, Indonesia

Alwiyah Mukaddas; Tatat Rahmita Utami; Amelia Rumi

doi:10.3889/oamjms.2020.4879

Authors

Alwiyah Mukaddas Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, Indonesia
Tatat Rahmita Utami Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, Indonesia
Amelia Rumi Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4879

Keywords:

Heart rate, Respiration rate, Glasgow Coma, Scale, Comorbid, Sepsis

Abstract

BACKGROUND: Treatment therapy with antibiotics is one of the factors supporting success in the treatment of sepsis.

AIM: This study aims to evaluate the use of antibiotics in patients with sepsis using parameters of the day of decline in body temperature, heart rate, respiration rate, changes in consciousness status, and comorbid factors.

MATERIALS AND METHODS: The design of this study is pilot study with a retrospective approach on sample of 14 sepsis patients who met the inclusion criteria. Descriptive analysis using the univariate method for see changes in levels of body temperature, length of stay, respiration rate, heart rate, comorbid factors, and changes in the consciousness status.

RESULTS: The results showed an average value for decline of body temperature after using antibiotics with a baseline of 38.47°C–37.87°C, heart rate shows the average value from baseline heart rate after using antibiotics from baseline of 110.8 bpm to 88.4 bpm, the respiration rate shows the average value for the respiration rate after using antibiotics from baseline of 30.8 x/min to 22.1 x/min, Glasgow Coma Scale (GCS) score showed an average value after using antibiotics from baseline 9 to 7, on comorbid factors showing six patients with one comorbid and eight patients with more than 1 comorbid factor.

CONCLUSION: The study concluded that body temperature is still in the category of fever, heart rate, and respiration rate which are the normal category, patient consciousness is still at the level of somnolence even though patient’s GCS score has decreased, and patients with one factor of comorbidities are faster in death because they have a fatal type of comorbid such as acute of hepatitis, coma hepaticum, and acute kidney injury.

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