Association of Parasite Density and Hematological Parameters of Plasmodium vivax- and Plasmodium falciparum-infected Patients Attending Merauke General Hospital, Papua, Indonesia

Authors

  • Roy Bagus Kurniawan Medical Doctor Study Programme, Faculty of Medicine, Universitas Airlangga, Jl. Prof. Dr. Moestopo No. 47 Surabaya, Indonesia
  • Puspa Wardhani Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Jl. Prof. Dr. Moestopo No. 47 Surabaya, Indonesia
  • Heny Arwati Department of Medical Parasitology, Faculty of Medicine, Universitas Airlangga, Jl. Prof. Dr. Moestopo No. 47 Surabaya, Indonesia
  • Aryati Aryati Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Jl. Prof. Dr. Moestopo No. 47 Surabaya, Indonesia
  • Trieva Verawaty Butarbutar Department of Clinical Pathology, Clinical Pathology Specialist Study Programme, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Jl. Prof. Dr. Moestopo No. 47 Surabaya, Indonesia
  • Christophorus Oetama Adiatmaja Department of Clinical Pathology, Clinical Pathology Specialist Study Programme, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Jl. Prof. Dr. Moestopo No. 47 Surabaya, Indonesia
  • Amarensi Milka Betaubun Department of Clinical Pathology, Clinical Pathology Specialist Study Programme, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Jl. Prof. Dr. Moestopo No. 47 Surabaya, Indonesia
  • Nur Chamidah Department of Mathematics, Faculty of Sciences and Technology, Universitas Airlangga, Jl. Mulyorejo Surabaya, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4881

Keywords:

Parasite density, hematology, malaria, Plasmodium vivax, Plasmodium falciparum

Abstract

BACKGROUND: Plasmodium falciparum and Plasmodium vivax are frequent causes of malaria. Although they are blood parasites, their biological characteristics are dissimilar, and their species-related consequences on hematological parameters have not been widely investigated. They might be valuable to distinguish both species infection, notably for an endemic region with limited diagnostic resources.

AIM: This study aimed to know the species-specific effect on hematological parameters and its correlation to the parasite density in P. vivax- and P. falciparum-infected patients attending Merauke General Hospital, Papua, Indonesia.

MATERIALS AND METHODS: Malaria patients confirmed by blood film microscopy from January 1 to July 31, 2019, were recruited, and their hematological parameters were measured using Sysmex XN-1000 instrument. All obtained data were analyzed statistically.

RESULTS: From 100 malaria-positive patients, 87 patients, consisting of 57 P. vivax and 30 P. falciparum patients, met criteria. Anemia and parasite density >50,000 parasites/μL were significantly higher in P. falciparum than P. vivax patients (p < 0.05) though hemoglobin concentration and parasite density were insignificantly different. Interestingly, basophil count was significantly higher in P. falciparum compared to P. vivax patients (p = 0.04). The eosinophil count was significantly higher in P. vivax (p = 0.01) than P. falciparum patients and indicated a significant positive correlation (p = 0.04, r = +0.28) with the parasite density.

CONCLUSION: There were significant differences between basophil and eosinophil count between P. vivax and P. falciparum infections. Eosinophil count showed a significant positive correlation with parasite density.

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Published

2020-10-10

How to Cite

1.
Kurniawan RB, Wardhani P, Arwati H, Aryati A, Butarbutar TV, Adiatmaja CO, Betaubun AM, Chamidah N. Association of Parasite Density and Hematological Parameters of Plasmodium vivax- and Plasmodium falciparum-infected Patients Attending Merauke General Hospital, Papua, Indonesia. Open Access Maced J Med Sci [Internet]. 2020 Oct. 10 [cited 2021 Apr. 16];8(B):825-31. Available from: https://oamjms.eu/index.php/mjms/article/view/4881

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Infective Diseases

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