Comparative Study of the Mucoadhesive Properties of Polymers for Pharmaceutical Use

Elena Bakhrushina; Maria Anurova; Natalia Demina; Alena Kashperko; Olga Rastopchina; Alexander Bardakov; Ivan Krasnyuk

doi:10.3889/oamjms.2020.4930

Authors

Elena Bakhrushina Sechenov First Moscow State University, Moscow, Russia
Maria Anurova Sechenov First Moscow State University, Moscow, Russia
Natalia Demina Sechenov First Moscow State University, Moscow, Russia
Alena Kashperko Sechenov First Moscow State University, Moscow, Russia
Olga Rastopchina Sechenov First Moscow State University, Moscow, Russia
Alexander Bardakov Sechenov First Moscow State University, Moscow, Russia
Ivan Krasnyuk Sechenov First Moscow State University, Moscow, Russia

DOI:

https://doi.org/10.3889/oamjms.2020.4930

Keywords:

mucoadhesion, excipients, evaluation of mucoadhesive properties, polymers, xanthan gum, polyethyleneglycol

Abstract

BACKGROUND: In recent years, mucoadhesive dosage forms due to their advantages have attracted the interest of researchers and developers. Polymeric excipients are included into the drug composition to give adhesion to the mucous membrane.

AIM: The aim of this research was to select a specific brand of pharmaceutical quality polymer that is promising for inclusion in the drug formulation.

METHODS: The article presents the results of studying the mucoadhesive properties of polymers on two models using mucin: By measuring the amount of adhesion and by the evaluation the sample movement speed.

RESULTS: According to the combination of two indicators, the highest mucoadhesive properties were shown by the brands of hydroxypropylmethylcellulose and xanthan gum. In addition, it was noted that hydroxyethylcellulose (HEC), sodium alginate, and hydroxypropylmethylcellulose (HPMC) also have good mucoadhesive properties. Polyethylene glycols proved to have the weakest mucoadhesive properties. The negative relationship between the average molecular weight and the sample movement speed of the HEC and HPMC was established. Obtained data showed no direct influence of the polymer average molecular weight on the amount of adhesion. It was also noted that there is no strong correlation between the amount of adhesion and the sample movement speed of the experimental samples.

CONCLUSION: Based on the results of the study, it was suggested that the complex influences of the physical and chemical properties of the polymer on its mucoadhesive properties.

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References

Kharenko EA, Larionova NI, Demina NB. Mucoadhesive drug delivery systems (review). Pharm Chem J. 2009;43:200-8. https://doi.org/10.1007/s11094-009-0271-6

Baus RA, Haug MF, Leichner C, Jelkmann M, Bernkop- Schnürch A. In Vitro-in Vivo correlation of mucoadhesion studies on buccal mucosa. Mol Pharm. 2019;16(6):2719-27. https://doi. org/10.1021/acs.molpharmaceut.9b00254 PMid:31038970

Kumar A, Naik PK, Pradhan D, Ghosh G, Rath G. Mucoadhesive formulations: Innovations, merits, drawbacks and future outlook. Pharm Dev Technol. 2020;25(7):797-814. https://doi.org/10.108 0/10837450.2020.1753771 PMid:32267180

Anurova MN, Bakhrushina, EO, Demina NB. Review of contemporary gel-forming agents in the technology of dosage forms. Pharm Chem J. 2015;49:627-34. https://doi.org/10.1007/ s11094-015-1342-5

Feng Q, Wei K, Lin S, Xu Z, Sun Y, Shi P, et al. Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration. Biomaterials. 2016;101:217-28. https://doi.org/10.1016/j.biomaterials.2016.05.043 PMid:27294539

Mustafin RI, Semina II, Garipova VR, Bukhovets AV, Sitenkov AY, Salakhova AR, et al. Comparative study of polycomplex oral drug delivery systems based on Carbopol® and oppositely charged polyelectrolytes as a new oral drug delivery system. Pharm Chem J. 2015;49(1):1-6. https://doi.org/10.1007/s11094-015-1211-2

Demouveaux B, Gouyer V, Magnien M, Plet S, Gottrand F, Narita T, et al. Gel-forming mucins structure governs mucus gels viscoelasticity. Med Sci (Paris). 2018;34(10):806-12. https://doi. org/10.1051/medsci/2018206 PMid:30451674

Ashland Global. Performance Specialties Reference Guide. Wilmington: Ashland Global. p. 78. Available from: https://www. brenntag.com/media/documents/bsi/product_data_sheets/ material_science/ashland_polymers/performance_specialties_ reference_guide.pdf. [Last accessed on 2020 Jan 10].

Lee K, Mooney D. Alginate: Properties and biomedical applications. Prog Polym Sci. 2012;37(1):106-26. https://doi. org/10.1016/j.progpolymsci.2011.06.003 PMid:22125349

Kumar A, Rao KM, Han SS. Application of xanthan gum as polysaccharide in tissue engineering: A review. Carbohydr Polym. 2018;180:128-44. https://doi.org/10.1016/j.carbpol.2017.10.009 PMid:29103488

Carbopol® Polymer Products. Available from: https:// www.lubrizol.com/en/Health/Pharmaceuticals/Excipients/ Carbopol%20Polymer%20Products.