A Review on the Novel Coronavirus and Its Effects on Children

Authors

  • Gholamreza Bahoush Department of Pediatrics, Ali Asghar Children’s Hospital, Faculty of Medicine, Iran University of Medical sciences, Tehran, Iran
  • Elham Zarei Department of Radiology, Ali Asghar Children’s Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.3889/oamjms.2020.4951

Keywords:

Coronavirus, Pneumonia, Immune system, Children, Risk factors, Coronavirus disease-19

Abstract

BACKGROUND: The outbreak of the new coronavirus was first reported in China and then spread to other parts of the world. The number of people infected with the virus is significantly increasing, making the disease an international concern.

AIM: The present study aimed to investigate the coronavirus and its effects on children.

MATERIALS AND METHODS: In the present study, search engines, and scientific databases of Google Scholar, Science Direct, PubMed, Medline, and Cochrane were searched to examine the effect of coronavirus on children. To collect information, keywords were also searched in the databases.

RESULTS: In spite of contradictory results, among the children, those under 5 years old are the high-risk group.

CONCLUSION: Some researchers believe that the virus shows fewer symptoms in children. However, the immune system of infants under six months develops pneumonia in rare cases.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet. 2020;395(10224):565-74. PMid:32007145

Cahyono B, Ariani J, Failasufa H, Suzery M. Extraction of homologous compounds of curcuminoid isolated from temulawak (Curcuma xanthorriza roxb.) plant. Rasayan J Chem. 2019;12(1):7-13. https://doi.org/10.31788/rjc.2019.1213092

Pediatric Branch of Hubei Medical Association; Pediatric Branch of Wuhan Medical Association; Pediatric Medical Quality Control Center of Hubei. Recommendation for the diagnosis and treatment of novel coronavirus infection in children in Hubei province (trial version 1). Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(2):96-9. https://doi.org/10.46234/ccdcw2020.022 PMid:32051073

Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of covid-19 in children in early January 2020 in Wuhan, China. N Engl J Med. 2020;382(14):1370-1. PMid:32163697

Cai J, Xu J, Lin D, Yang Z, Xu L, Qu Z, et al. A case series of children with 2019 novel coronavirus infection: Clinical and epidemiological features. Clin Infect Dis. 2020;2020:ciaa198. PMid:32112072

Medical Expert Group of Tongji Hospital. Quick Guide to the Diagnosis and Treatment of Pneumonia for Novel Coronavirus Infections. 3rd ed. New Zealand: Herald of Medicine; 2020. Available from: http://www.kns.cnki.net/kcms/detail/42.129 3.r.20200130.1803.002.html. [Last accessed on 2020 Feb 02].

Mission T. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Geneva: World Health Organization; 2020.

Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020;382(10):970-71. PMid:32003551

Drexler JF, Gloza-Rausch F, Glende J, Corman VM, Muth D, Goettsche M, et al. Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences. J Virol. 2010;84(21):11336-49. https://doi.org/10.1128/jvi.00650-10 PMid:20686038

Zhavoronkov A, Aladinskiy V, Zhebrak A, Zagribelnyy B, Terentiev V, Bezrukov DS, et al. Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches. Hong Kong: Insilico Medicine Ltd.; 2020. p. 307.

Liu X, Zhang B, Jin Z, Yang H, Rao Z. The Crytal Structure of 2019-NCoV Main Protease in Complex with an Inhibitor N3. United States: RCSB Protein Data Bank; 2020.

Liu X, Wang XJ. Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines. J Genet Genomics. 2020;47(2):119-21. https://doi.org/10.1016/j. jgg.2020.02.001 PMid:32173287

Chang KO, Kim Y, Lovell S, Rathnayake AD, Groutas WC. Antiviral drug discovery: Norovirus proteases and development of inhibitors. Viruses. 2019;11(2):197. https://doi.org/10.3390/ v11020197 PMid:30823509

Yamamoto N, Yang R, Yoshinaka Y, Amari S, Nakano T, Cinatld J, et al. HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus. Biochem Biophys Res Commun. 2004;318(3):719-25. https://doi.org/10.1016/j.bbrc.2004.04.083

Li JY, You Z, Wang Q, Zhou ZJ, Qiu Y, Luo R, et al. The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future. Microbes Infect. 2020;22(2):80-5. https://doi.org/10.1016/j.micinf.2020.02.002 PMid:32087334

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. PMid:32031570

Wang C, Wang X. Prevalence, nosocomial infection and psychological prevention of novel coronavirus infection. Chin General Pract Nurs. 2020;18:2-3.

World Health Organization. Coronavirus Disease (COVID- 2019) Situation Reports; 2020. Available from: https://www. who.int/emergencies/diseases/novel-coronavirus2019/ situation-reports.

Cruz A, Zeichner S. COVID-19 in children: Initial characterization of the pediatric disease. Pediatrics. 2020;145(6):e20200834. https://doi.org/10.1542/peds.2020-0834 PMid:32179659

Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatr Pulmonol. 2020;55(5):1169-74. PMid:32134205

Wei M, Yuan J, Liu Y, Fu T, Yu X, Zhang ZJ. Novel coronavirus infection in hospitalized infants under 1 year of age in China. JAMA. 2020;323(13):1313-4. PMid:32058570

Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med. 2020;58(7):1131-4. https://doi.org/10.1515/cclm-2020-0198 PMid:32119647

Wang X, Yuan J, Zheng YJ, Chen J, Bao YM, Wang YR, et al. Retracted: Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen. Zhonghua Er Ke Za Zhi. 2020;58:E008. PMid:32062875

Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N, et al. Chest CT findings in coronavirus disease-19 (COVID-19): Relationship to duration of infection. Radiology. 2020;295(3):200463. https://doi.org/10.1148/radiol.2020200463

Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: An observational cohort study. Lancet Infect Dis. 2020;20(6):P689-96. https://doi. org/10.1016/s1473-3099(20)30198-5

Li YT, Liang Y, Ling YS, Duan MQ, Pan L, Chen ZG. The spectrum of viral pathogens in children with severe acute lower respiratory tract infection: A 3-year prospective study in the pediatric intensive care unit. J Med Virol. 2019;91(9):1633-42. https://doi.org/10.1002/jmv.25502 PMid:31081548

Heimdal I, Moe N, Krokstad S, Christensen A, Skanke LH, Nordbø SA, et al. Human coronavirus in hospitalized children with respiratory tract infections: A 9-year population-based study from Norway. J Infect Dis. 2019;219(8):1198-206. https:// doi.org/10.1093/infdis/jiy646 PMid:30418633

Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145(6):e20200702. PMid:32179660

Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, et al. Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors. Nat Struct Mol Biol. 2019;26(12):1151-7. https://doi.org/10.1038/ s41594-019-0334-7 PMid:31792450

Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS coronavirus. J Virol. 2020;94(7):20.

Diao B, Wang C, Tan Y, Chen X, Liu Y, Ning L, et al. Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19). Front Immunol. 2020;11:827. https:// doi.org/10.3389/fimmu.2020.00827 PMid:32425950

Channappanavar R, Zhao J, Perlman S. T cell-mediated immune response to respiratory coronaviruses. Immunol Res. 2014;59(1-3):118-28. https://doi.org/10.1007/s12026-014-8534-z PMid:24845462

McComb S, Thiriot A, Krishnan L, Stark F. Introduction to the immune system. In: Methods and Protocols, Methods in Molecular Biology. Ch. 1. Berlin, Germany: Springer; 2013. p. 1061. https://doi.org/10.1007/978-1-62703-589-7_1

Yewdell JW, Bennink JR. Mechanisms of Viral Interference with MHC Class I Antigen Processing and Presentation. Annu Rev Cell Dev Biol. 1999;15:579-606. PMid:10611973

Tordesillas L, Lozano-Ojalvo D, Dunkin D, Mondoulet L, Agudo J, Merad M, et al. PDL2(+) CD11b(+) dermal dendritic cells capture topical antigen through hair follicles to prime LAP(+) tregs. Nat Commun. 2018;9(1):5238. https://doi. org/10.1038/s41467-018-07716-7 PMid:30531969

Kawai T, Shizuo A. Innate immune recognition of viral infection. Nat Immunol. 2006;7(2):131-7. PMid:16424890

Li G, Fan Y, Lai Y, Zonghui L, Peiwen Z, Pan P, et al. Coronavirus infections and immune responses. J Med Virol. 2020;92(4):424-32. PMid:31981224

Yazdanpanah F, Hamblin MR, Rezaei N. The immune system and COVID-19: Friend or foe? Life Sci. 2020 Sep 1; 256: 117900. PMid:2502542

Tufan A, Avanoğlu Güler A, Matucci-Cerinic M. COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs. Turk J Med Sci. 2020; 50(3): 620-632.

Capolunghi F, Rosado MM, Sinibaldi M, Aranburu A, Carsetti R. Why do we need IgM memory B cells? Immunol Lett. 2013;152(2):114-20. https://doi.org/10.1016/j.imlet.2013.04.007 PMid:23660557

Throsby M ,van den Brink E, Jongeneelen M, Poon LL, Alard P, Cornelissen L, et al. Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS One. 2008;3(12):3e3942. https://doi.org/10.1371/journal.pone.0003942 PMid:19079604

Grimsholm O, Mortari EP, Davydov AN, Shugay M, Obraztsova AS, Bocci C, et al. The interplay between CD27dull and CD27bright B cells ensures the flexibility, stability, and resilience of human B cell memory. Cell Rep. 2020;30(9):2963-77. https://doi.org/10.1016/j.celrep.2020.02.022 PMid:32130900

Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends. 2020;14(1):72-3. https://doi.org/10.5582/bst.2020.01047 PMid:32074550

Peterhans E. Oxidants and antioxidants in viral diseases: Disease mechanisms and metabolic regulation. J Nutr. 1997;127(5):962S-5. https://doi.org/10.1093/jn/127.5.962s PMid:9164274

Tenero L, Piazza M, Zanoni L, Bodini A, Peroni D, Piacentini GL. Antioxidant supplementation and exhaled nitric oxide in children with asthma. Allergy Asthma Proc. 2016;37(1):e8-13. https://doi. org/10.2500/aap.2016.37.3920 PMid:26831840

Jin YH, Cai L, Cheng ZS, Cheng H, Deng T, Fan YP, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Military Med Res. 2020;7(1):4.

Ghosh AK, Osswald HL, Prato G. Recent progress in the development of HIV-1 protease inhibitors for the treatment of HIV/AIDS. J Med Chem. 2016;59(11):5172-208. https://doi. org/10.1021/acs.jmedchem.5b01697 PMid:26799988

Bolles M, Deming D, Long K, Agnihothram S, Whitmore A, Ferris M, et al. A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge. J Virol. 2011;85(23):12201-15. https://doi.org/10.1128/jvi.06048-11 PMid:21937658

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239-42. https://doi.org/10.1001/jama.2020.2648

Gh NM, Oskouie AA, Aliannejad R, Rezaei-Tavirani M, Tavallaie S, Baghban AA, et al. Pro-oxidant-antioxidant balance in Iranian veterans with sulfur mustard toxicity and different levels of pulmonary disorders. Drug Chem Toxicol. 2016;39(4):362-6. https://doi.org/10.3109/01480545.2015.1122033

Downloads

Published

2020-10-20

How to Cite

1.
Bahoush G, Zarei E. A Review on the Novel Coronavirus and Its Effects on Children. Open Access Maced J Med Sci [Internet]. 2020 Oct. 20 [cited 2024 Nov. 2];8(T1):233-9. Available from: https://oamjms.eu/index.php/mjms/article/view/4951