Tunicamycin Anticancer Drug May Reliable to Treat Coronavirus Disease-19

Ali Dawood; Haitham Abdul-Malik Alnori

doi:10.3889/oamjms.2020.4954

Authors

Ali Dawood Department of Anatomy, Medical Biology, College of Medicine, University of Mosul, Mosul, Iraq
Haitham Abdul-Malik Alnori Department of Surgery, College of Medicine, University of Mosul, Mosul, Iraq

DOI:

https://doi.org/10.3889/oamjms.2020.4954

Keywords:

Tunicamycin, Glycosylation, Virion, Coronavirus, Post-translational modification

Abstract

BACKGROUND: SARS-CoV-2 outbreaks remains a medical and economic challenge, due to the lack of a suitable drug or vaccine. The glycan in some proteins plays an important role in protein folding, sorting, transport, and oligomerization, so the hindering of N-linked glycosylation of glycoproteins will prevent assembly of the virion. Tunicamycin anticancer drug inhibits the N- linked glycan.

AIM: This study aimed to find out the mechanism action of tunicamycin on the viral glycoproteins.

RESULTS: The growth of the virus in the presence of tunicamycin conducted in the production of non-infectious and absence of spike protein (spikeless virions). Tunicamycin inhibits E2, S, and M glycoproteins of coronaviruses. Tunicamycin has also diminished glycosylation of PTMs such as HE, and 8ab of SARS-CoV. Finally,

CONCLUSION: This study recommends using this drug to treat the SARS-CoV-2.

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