Experience of Cancer Patients for the Usage of Complementary and Alternative Medicine Therapy
DOI:
https://doi.org/10.3889/oamjms.2020.5012Keywords:
Cancer patients, CAM therapy, chemotherapy, green tea, black seedsAbstract
BACKGROUND: Cancer patients have always been reported to have multiple complications and the treatment has always seemed challenging. The complementary and alternative medicine (CAM) therapy has widely accepted by the patients with various disorders.
AIM: This study evaluated the experience of cancer patients for the usage of CAM therapy.
MATERIALS AND METHODS: This is a cross-sectional study designed to determine the experience of cancer patients for the usage of CAM therapy.
RESULTS: Out of 232 cancer patients, 94% were urban residents and were non-smokers. Importantly, 66.4% of cancer patients experienced that the combination of CAM with conventional chemotherapy was effective for their treatment. Among all CAM therapies, 31.5% cancer patients experienced that herbal medicines/herbs were good. Among herbal therapies, green tea and black seeds were most effective for cancer patients. In contrast, 12.5% patients experienced that homeopathic medicines were good for their treatment.
CONCLUSIONS: To the best of our knowledge, this is the first comprehensive study from Saudi Arabia to show the experience of cancer patients toward the usage of CAM therapy. Most of the cancer patients experienced that CAM therapies with the convention chemotherapy were effective for their treatment. Among all studied CAM therapies, green tea and black seeds were suggested by most of the cancer patients for their treatment.
Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Torre LA, Islami F, Siegel RL, Ward EM, Jemal A. Global cancer in women: Burden and trends. Cancer Epidemiol Biomarkers Prev. 2017;26(4):444-57. https://doi.org/10.1158/1055-9965. epi-16-0858 PMid:28223433
Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends an update. Cancer Epidemiol Biomarkers Prev. 2016;25(1):16-27. https://doi. org/10.1158/1055-9965.epi-15-0578 PMid:26667886
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87- 108. https://doi.org/10.3322/caac.21262 PMid:25651787
Cresanta JL. Epidemiology of cancer in the United States. Prim Care. 1992;19(3):419-41. PMid:1410056
Bazarbashi S, Al Eid H, Minguet J. Cancer incidence in Saudi Arabia: 2012 data from the Saudi cancer registry. Asian Pac J Cancer Prev. 2017;18(9):2437-44. PMid:28952273
Rudat V, Brune-Erbe I, Noureldin A, Bushnag Z, Almuraikhi N, Altuwaijri S. Epidemiology of breast cancer patients at a tertiary care center in the Eastern Province of Saudi Arabia. Gulf J Oncolog. 2012;11:45-9. PMid:22227545
Herzallah HK, Antonisamy BR, Shafee MH, Al-Otaibi ST. Temporal trends in the incidence and demographics of cancers, communicable diseases, and non-communicable diseases in Saudi Arabia over the last decade. Saudi Med J. 2019;40(3):277- 86. https://doi.org/10.15537/smj.2019.3.23585 PMid:30834424
Jabour AM, Dixon BE. Monitoring public health reporting: Data tracking in cancer registries. Online J Public Health Inform. 2018;10(3):e220. https://doi.org/10.5210/ojphi.v10i3.9432 PMid:30680053
Ernst E. The role of complementary and alternative medicine. Br Med J. 2000;321:1133-5. PMid:11061738
Molassiotis A, Fernández-Ortega P, Pud D, Ozden G, Scott JA, Panteli V, et al. Use of complementary and alternative medicine in cancer patients: A European survey. Ann Oncol. 2005;16(4):655-63. https://doi.org/10.1093/annonc/mdi110 PMid:15699021
Ernst E, Cassileth BR. The prevalence of complementary/ alternative medicine in cancer. A systematic review. Cancer. 1998;83(4):777-82. https://doi.org/10.1002/ (sici)1097-0142(19980815)83:4<777::aid-cncr22>3.0.co;2-o PMid:9708945
Niggemann B, Gruber C. Side-effects of complementary and alternative medicine. Allergy. 2003;58(8):707-16. https://doi. org/10.1034/j.1398-9995.2003.00219.x PMid:12859546
Richardson MA, Sanders T, Palmer JL, Greisinger A, Singletary SE. Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol. 2000;18(13):2505-14. https://doi.org/10.1200/ jco.2000.18.13.2505 PMid:10893280
Oneschuk D, Fennell L, Hanson J, Bruera E. The use of complementary medications by cancer patients attending an outpatient pain and symptom clinic. J Palliat Care. 1998;14(4):21-6. https://doi.org/10.1177/082585979801400404 PMid:9893394
Bernstein BJ, Grasso T. Prevalence of complementary and alternative medicine use in cancer patients. Oncology. 2001;15(10):1267-72. PMid:11702957
Sparber A, Bauer L, Curt G, Eisenberg D, Levin T, Parks S, et al. Use of complementary medicine by adult patients participating in cancer clinical trials. Oncol Nurs Forum. 2000;27:623-30. t https://doi.org/10.1097/01893697-200119020-00031 PMid:10833691
Swisher EM, Cohn DE, Goff BA, Parham J, Herzog TJ, Rader JS, et al. Use of complementary and alternative medicine among women with gynecologic cancers. Gynecol Oncol. 2002;84(3):363-7. https://doi.org/10.1006/gyno.2001.6515 PMid:11855870
Von Gruenigen VE, White LJ, Kirven MS, Showalter AL, Hopkins MP, Jenison EL. A comparison of complementary and alternative medicine use by gynecology and gynecologic oncology patients. Int J Gynecol Cancer. 2001;11:205-9. https:// doi.org/10.1046/j.1525-1438.2001.01011.x PMid:11437926
Bennett M, Lengacher C. Use of complementary therapies in a rural cancer population. Oncol Nurs Forum. 1999;26:1287-94. PMid:10497768
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34. PMid:30620402
Shah SC, Kayamba V, Peek RM Jr., Heimburger D. Cancer control in low- and middle-income countries: Is it time to consider screening? J Glob Oncol. 2019;5:1-8. https://doi.org/10.1200/ jgo.18.00200 PMid:30908147
Cialdella-Kam L, Sabado P, Bispeck MK, Silverman S, Bernstein L, Krawiec V, et al. Implementing cancer prevention into clinical practice. J Cancer Educ. 2012;27(Suppl 2):S136-43. https://doi.org/10.1007/s13187-012-0331-6 PMid:22367592
Jazieh AR, AlGhamdi M, AlGhanem S, AlGarni M, AlKattan K, AlRujaib M, et al. Saudi lung cancer prevention and screening guidelines. Ann Thorac Med. 2018;13(4):198-204. https://doi. org/10.4103/atm.atm_147_18 PMid:30416590
Meyskens FL Jr., Mukhtar H, Rock CL, Cuzick J, Kensler TW, Yang CS, et al. Cancer prevention: Obstacles, challenges and the road ahead. J Natl Cancer Inst. 2015;108(2):djv309. https:// doi.org/10.1093/jnci/djv309 PMid:26547931
Devlin EJ, Denson LA, Whitford HS. Cancer treatment side effects: A meta-analysis of the relationship between response expectancies and experience. J Pain Symptom Manage 2017;54(2):245-58. https://doi.org/10.1016/j. jpainsymman.2017.03.017 PMid:28533160
Wode K, Henriksson R, Sharp L, Stoltenberg A, Hok Nordberg J. Cancer patients’ use of complementary and alternative medicine in Sweden: A cross-sectional study. BMC Complement Altern Med. 2019;19(1):62. https://doi.org/10.1186/s12906-019-2452-5 PMid:30866916
Rasheed Z. Molecular evidences of health benefits of drinking black tea. Int J Health Sci (Qassim). 2019;13(3):1-3. PMid:31123432
Rasheed Z. Medicinal values of bioactive constituents of camel milk: A concise report. Int J Health Sci (Qassim). 2017;11(5):1-2. PMid:29114185
Rasheed Z. Green tea bioactive polyphenol epigallocatechin- 3-O-Gallate in osteoarthritis: Current status and future perspectives. Int J Health Sci (Qassim). 2016;10(4):5-8. https:// doi.org/10.12816/0048888
Rasheed Z, Rasheed N, Al-Shaya O. Epigallocatechin-3-O-gallate modulates global microRNA expression in interleukin- 1β-stimulated human osteoarthritis chondrocytes: potential role of EGCG on negative co-regulation of microRNA-140-3p and ADAMTS5. Eur J Nutr. 2018;57(3):917-28. https://doi. org/10.1007/s00394-016-1375-x PMid:28110479
Rasheed Z, Altorbag AA, Al-Bossier AS, Alnasser NA, Alkharraz OS, Altuwayjiri KM, et al. Protective potential of thymoquinone against peroxynitrite induced modifications in histone H2A: In vitro studies. Int J Biol Macromol. 2018;112:169- 74. https://doi.org/10.1016/j.ijbiomac.2018.01.157 PMid:29414727
Rasheed Z, Rasheed N, Al-Shobaili HA. Epigallocatechin- 3-O-gallate up-regulates microRNA-199a-3p expression by down-regulating the expression of cyclooxygenase-2 in stimulated human osteoarthritis chondrocytes. J Cell Mol Med. 2016;20(12):2241-8. https://doi.org/10.1111/jcmm.12897 PMid:27515563
Rasheed Z. Intake of pomegranate prevents the onset of osteoarthritis: Molecular evidences. Int J Health Sci (Qassim). 2016;10(2):5-8. https://doi.org/10.12816/0048807
Rasheed N, Alghasham A, Rasheed Z. Lactoferrin from Camelus dromedarius inhibits nuclear transcription factor-kappa B activation, cyclooxygenase-2 expression and prostaglandin E2 production in stimulated human chondrocytes. Pharmacogn Res. 2016;8(2):135-41. https://doi.org/10.4103/0974-8490.175612 PMid:27034605
Rasheed Z, Akhtar N, Haqqi TM. Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes. Arthritis Res Ther. 2010;12(5):R195. https://doi. org/10.1186/ar3166 PMid:20955562
Rasheed Z, Akhtar N, Khan A, Khan KA, Haqqi TM. Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: Suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. J Pharmacol Exp Ther. 2010;333(2):354-63. https://doi.org/10.1124/jpet.109.165209 PMid:20164300
Rasheed Z, Anbazhagan AN, Akhtar N, Ramamurthy S, Voss FR, Haqqi TM. Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes. Arthritis Res Ther. 2009;11(3):R71. https://doi.org/10.1186/ar2700 PMid:19445683
Rasheed Z, Akhtar N, Anbazhagan AN, Ramamurthy S, Shukla M, Haqqi TM. Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-kappaB in human KU812 cells. J Inflamm (Lond). 2009;6:1. https://doi.org/10.1186/1476-9255-6-1 PMid:19133134
Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM. Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro. J Inflamm (Lond). 2008;5:9. https://doi.org/10.1186/1476-9255-5-9 PMid:18554383
Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition. 2008;24(7-8):733-43. https://doi. org/10.1016/j.nut.2008.03.013 PMid:18490140
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2020 Zafar Rasheed, Mohammed Al-Rashidy, Anas Al-Raqibah, Abdulrahman Al-Moqbel, Abdulmajeed Al-Bakri, Abdulaziz Al-Harbi, Naila Rasheed, Waleed Al Abdulmonem (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0