Convalescent Plasma Therapy in Effort of Weaning from Mechanical Ventilation Using Music Stimulation in Severe COVID-19 Patients


  • Made Ayu Dessy Dwitasari Department of Resident of Neurology, Medical Faculty, Udayana University, Sanglah General Hospital, Indonesia
  • Anak Agung Ayu Putri Laksmidewi Department of Neurology, Medical Faculty, Udayana University, Sanglah General Hospital, Indonesia



COVID-19, Severe acute respiratory syndrome-CoV-2 infection, Weaning failure from mechanical ventilation, music stimulation in mechanical ventilation


Nowadays, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or CoV disease of 2019 (COVID-19) infection is a big threat to global health and becomes a global pandemic. The exact treatment for this disease is still an on-going experiment. Meanwhile, there are more people infected by this disease, leading to severe acute respiratory syndrome (SARS). COVID-19 patients with severe clinical symptoms may need mechanical ventilation. These patients at the same time, struggle with the infection and also the effort to wean from the ventilation. Weaning failure commonly occurred in patients with severe respiratory disease. In this article, we discuss the use of convalescence plasma therapy and the benefit of music stimulation for weaning from mechanical ventilation in COVID-19 patients.



Download data is not yet available.


Metrics Loading ...

Plum Analytics Artifact Widget Block


Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-3. PMid:32015507

World Health Organization, Coronavirus Disease (COVID-19) Pandemic. Available from: diseases/novel-coronavirus-2019. [Last accessed on 2020 Mar 11].

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239-42. PMid:32091533

Channappanavar R, Perlman S. Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 2017;39(5):529-39. PMid:28466096

Mahdi BM. COVID-19 Type III hypersensitivity reaction. Med Hypotheses 2020;140:109763. mehy.2020.109763 PMid:32344307

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 2020;395(10223):507-13. s0140-6736(20)30211-7 PMid:32007143

Huang C, Wang Y, Li X, Ren L, Zhao I, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.

Ko JH, Seok H, Cho SY, Ha YE, Baek JY, Kim SH, et al. Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: A single centre experience. Antivir Ther. 2018;23(7):617-22. https://doi. org/10.3851/imp3243 PMid:29923831

Hung IF, To KK, Lee CK, Lee KL, Chan K, Yan WW, et al. Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection. Clin Infect Dis. 2011;52(4):447-56. PMid:21248066

Cheng Y, Wong R, Soo YO, Wong WS, Lee CK, Ng MH, et al. Use of convalescent plasma therapy in SARS patients in Hong Kong. Eur J Clin Microbiol Infect Dis. 2005;24(1):44-6. https:// PMid:15616839

Karthick R, Krishnasamy N, Jayanthi R, Jeyalalitha R, Murugan N, Arunkumar R. Convalescent plasma transfusion for the treatment of COVID-19: Systematic review. J Med Virol. 2020;1- 9. PMid:32356910

Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et al. Treatment of 5 critically ill patients with covid-19 with convalescent plasma. JAMA 2020;323(16):1582-9. jama.2020.4783 PMid:32219428

Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367(19):1814- 20. PMid:23075143

Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First case of 2019 novel coronavirus in the United States. N Engl J Med. 2020;382(10):929-36. https://doi. org/10.1056/NEJMoa2001191 PMid:32004427

Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis. 2020;20(4):398-400. PMid:32113510

Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci U S A. 2020;117(17):9490-6. PMid:32253318

Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et al. Treatment of 5 critically ill patients with covid-19 with convalescent plasma. JAMA 2020;323(16):1582-9. jama.2020.4783 PMid:32219428

Carlucci A, Richard JC, Wysocki M, Lepage E, Brochard L. Noninvasive versus conventional mechanical ventilation: An epidemiologic survey. Am J Respir Crit Care Med. 2001;163(4):874- 80. PMid:11282759

Demoule A, Girou E, Richard JC, Taille S, Brochard L. Increased use of noninvasive ventilation in French intensive care units. Intensive Care Med. 2006;32(11):1747-55. https://doi. org/10.1007/s00134-006-0229-z PMid:16799775

Eskandar N, Apostolakos MJ. Weaning from mechanical ventilation. Crit Care Clin. 2007;23(2):263-74. https://doi. org/10.1016/j.ccc.2006.12.002 PMid:17368170

Pustavoitau A, Stevens RD. Mechanisms of neurologic failure in critical illness. Crit Care Clin. 2008;24(1):1-24. https://doi. org/10.1016/j.ccc.2007.11.004 PMid:18241776

Hopkins RO, Jackson JC. Long-term neurocognitive function after critical illness. Chest. 2006;130(3):869-78. https://doi. org/10.1378/chest.130.3.869 PMid:16963688

Pandharipande P, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: The MENDS randomized controlled trial. J Am Med Assoc. 2007;298(22):2644-53. PMid:18073360

Gonzalvo R, Marti-Sistac O, Blanch L, López-Aguilar J. Bench-to-bedside review: Brain-lung interaction in the critically ill-a pending issue revisited. Crit Care. 2007;11(3):216. https://doi. org/10.1186/cc5930 PMid:17581271

Stawicki SP. Mechanical ventilation: Weaning and extubation. OPUS 12 Sci. 2007;1(2):13-6.

Hopkins SJ. Central nervous system recognition of peripheral inflammation: A neural, hormonal collaboration. Acta Biomed. 2007;78(1):231-47. PMid:17465337

Capurn L, Miller AH. Immune system to brain signaling: Neuropsychopharmacological implication. Pharmacol Ther. 2011;130(2):226-38. PMid:21334376

Coplin WM, Pierson DJ, Cooley KD, Newell DW, Rubenfeld GD. Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med. 2000;161(5):1530-6. PMid:10806150

Stevens RD. The brain-lung axis. Intensive Care Med. 2011;37(7):1054-6. PMid:21544691

Tracy MF, Chlan L. Nonpharmacological interventions to manage common symptoms in patients receiving mechanical ventilation. Crit Care Nurse. 2011;31(3):19-28. https://doi. org/10.4037/ccn2011653 PMid:21632591

Hunter BC, Oliva R, Sahler OJ, Gaisser D, Salipante DM, Arezina CH. Music therapy as an adjunctive treatment in the management of stress for patients being weaned from mechanical ventilation. J Music Ther. 2010;47(3):198-219. PMid:21275332

Lee CH, Chang SH, Wang SM, Lai CH, Lai LM. The effects of a musical intervention on the anxiety level of mechanical ventilation patients: A pilot study. Cheng Ching Med J. 2015;11:31-8.

Lee OK, Chung YF, Chan MF, Chan WM. Music and its effect on the physiological responses and anxiety levels of patients receiving mechanical ventilation: A pilot study. J Clin Nurs. 2005;14(5):609- 20. PMid:15840076

Blackwood B. The art and science of predicting patients readiness for weaning from mechanical ventilation. Int J Nurs Stud. 2000;37(2):145-51. PMid:10684956




How to Cite

Dwitasari MAD, Laksmidewi AAAP. Convalescent Plasma Therapy in Effort of Weaning from Mechanical Ventilation Using Music Stimulation in Severe COVID-19 Patients. Open Access Maced J Med Sci [Internet]. 2020 Sep. 20 [cited 2021 Oct. 19];8(T1):192-7. Available from:

Most read articles by the same author(s)