Coronavirus Disease-19 and Liver Injury


  • Gontar Alamsyah Siregar Department of Internal Medicine, Division of Gastroenterohepatology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Ginanda Putra Siregar Department of Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Darmadi Darmadi Department of Internal Medicine, Division of Gastroenterohepatology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Riska Habriel Ruslie Department of Child Health, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia



COVID-19, liver, SARS-CoV-2


Coronavirus Disease (COVID)-19 is a pandemic since March 11, 2020. The total case is more than a half million worldwide. Liver injury is quite common in COVID-19 patients. Direct viral infection is possible due to the presence of angiotensin converting enzyme 2 in cholangiocytes and hepatocytes. Other proposed mechanisms are virus-induced cytopathic effects, inflammation process, hypoxia and shock, increased apoptotic activity, increased positive end expiratory effect, and drug-induced. The manifestation of liver injury is mild and transient with elevated liver enzymes, bilirubin, and gamma-glutamyl transferase levels. Deterioration of liver function can occur in subjects with COVID-19 and underlying liver injury. The management is principally supportive. Hepatoprotective drugs may be administered in severe cases.


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How to Cite

Siregar GA, Siregar GP, Darmadi D, Ruslie RH. Coronavirus Disease-19 and Liver Injury. Open Access Maced J Med Sci [Internet]. 2020 Sep. 30 [cited 2022 Jul. 1];8(T1):154-7. Available from:

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