Iraqi Women with Preeclampsia: Maternal and Neonatal Outcomes
DOI:
https://doi.org/10.3889/oamjms.2020.5043Keywords:
Cesarean section, Hypertension, Low birth weight, Pregnancy weight gain, Preterm birthAbstract
BACKGROUND: Preeclampsia (PE) is a possible etiology of obstetrical and neonatal complications which are increased in resource-limited settings and developing countries.
AIM: We aimed to find out the prevalence of PE in Iraqi ladies and specific outcomes, including gestational weight gain (GWG), cesarean section (CS), preterm delivery (PD), and low birth weight (LBW).
METHODS: All singleton pregnant women visiting our tertiary center for delivery were involved over 3 years. PE women were compared with non-PE ladies. Complete history and examination were done during pregnancy and after delivery by the attending obstetrician and neonatologist with full documentation in medical records.
RESULTS: PE prevalence was 4.79%, and the affected women had significant (p < 0.05) higher age, body mass index, and GWG, but lower gestational age at delivery. The mean significant difference of GWG in PE and non-PE patients was 1.82 kg. PD and LBW had significant higher frequencies in PE. After considering several confounding factors, crude and adjusted odds ratio (OR) of PE with 95% confidence interval (95% CI) were significant in CS (crude OR = 2.25 and 95% CI = 1.42-2.87 while adjusted OR = 2.89 and 95% CI = 1.43–3.06) and PD (crude OR = 2.41 and 95% CI = 1.73–2.46 while adjusted OR = 3.96 and 95% CI = 2.65–6.37). On the other hand, only the crude model touched significance in LBW (crude OR = 3.67 and 95% CI = 2.51–4.99).
CONCLUSIONS: Prevalence of PE in Iraqi pregnant females was higher than other neighboring developing countries. In PE ladies, maternal parameters, including GWG and operative delivery, and neonatal complications, including PD and LBW, were significantly higher than pregnant women without PE.
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Colvin ZA, Feng M, Pan AY, Palatnik A. 979: Duration of labor induction in nulliparous women with preeclampsia and maternal and neonatal outcomes. Am J Obstetr Gynecol. 2020;222(1):S608. https://doi.org/10.1016/j.ajog.2019.11.990
Ratsiatosika AT, Razafimanantsoa E, Andriantoky VB, Ravoavison N, Hery RA, Boukerrou M, et al. Incidence and natural history of preeclampsia/eclampsia at the university maternity of Antananarivo, Madagascar: High prevalence of the early-onset condition. J Matern Fetal Neonatal Med. 2019;32(19):3266-71. https://doi.org/10.1080/14767058.2018.1 462323 PMid:29621911
Ananth CV, Keyes KM, Wapner RJ. Pre-eclampsia rates in the United States, 1980-2010: Age-period-cohort analysis. BMJ. 2013;347:f6564. https://doi.org/10.1136/bmj.f6564
Ngwenya S, Jones B, Heazell AE, Mwembe D. Statistical risk prediction models for adverse maternal and neonatal outcomes in severe preeclampsia in a low-resource setting: Proposal for a single-centre cross-sectional study at Mpilo central hospital, Bulawayo, Zimbabwe. BMC Res Notes. 2019;12(1):500. https:// doi.org/10.1186/s13104-019-4539-y PMid:31409378
Abdulshaheed NA, Al-Habib MF. Electron microscopic study of the effects of preeclampsia on the placental endothelial cells ultra structures during pregnancy. Al-Kindy Coll Med J. 2010;6(1):39-44.
Zoet GA, Koster MP, Velthuis BK, de Groot CJ, Maas AH, Fauser BC, et al. Determinants of future cardiovascular health in women with a history of preeclampsia. Maturitas. 2015;82(2):153- 61. https://doi.org/10.1016/j.maturitas.2015.07.004 PMid:26255680
Ton TG, Bennett MV, Incerti D, Peneva D, Druzin M, Stevens W, et al. Maternal and infant adverse outcomes associated with mild and severe preeclampsia during the first year after delivery in the United States. Am J Perinatol. 2020;37(4):398-408. https://doi.org/10.1055/s-0039-1679916 PMid:30780187
Weitzner O, Yagur Y, Weissbach T, Man El G, Biron-Shental T. Preeclampsia: Risk factors and neonatal outcomes associated with early-versus late-onset diseases. J Matern Fetal Neonatal Med. 2020;33(5):780-4. https://doi.org/10.1080/14767058.2018 .1500551 PMid:30001660
Ver Luanni Bilano EO, Ganchimeg T, Mori R, Souza JP. Risk factors of pre-eclampsia/eclampsia and its adverse outcomes in low-and middle-income countries: A WHO secondary analysis. PLoS One. 2014;9(3):e91198. https://doi.org/10.1371/journal. pone.0091198 PMid:24657964
Jasim SK, Al-Momen H, Al-Asadi F. Maternal anemia prevalence and subsequent neonatal complications in Iraq. Open Access Maced J Med Sci. 2020;8:71-5. https://doi.org/10.3889/ oamjms.2020.3593
Phoa KY, Chedraui P, Pérez-López FR, Wendte JF, Ghiabi S, Vrijkotte T, et al. Perinatal outcome in singleton pregnancies complicated with preeclampsia and eclampsia in Ecuador. J Obstetr Gynaecol. 2016;36(5):581-4. https://doi.org/10.3109/01 443615.2015.1107532 PMid:26790539
Jasim SK, Al-Momen H, Al-Naddawi AM. Prediction of maternal diabetes and adverse neonatal outcome in normotensive pregnancy using serum uric acid. Int J Res Pharm Sci. 2019;10(4):3563-9. https://doi.org/10.26452/ijrps.v10i4.1736
Jasim SK, Al-Momen H, Majeed BA, Hussein MJ. Rate of fetal macrosomia with maternal and early neonatal complications in internally moved people affected by violence. Int J Med Res Health Sci. 2018;7(7):141-6.
Al-Momen H, Muhammed MK, Alshaheen AA. Neonatal seizures in Iraq: Cause and outcome. Tohoku J Exp Med. 2018;246(4):245-9. https://doi.org/10.1620/tjem.246.245
Sakamoto Y, Ishiguro M, Kitagawa G. Akaike Information Criterion Statistics. Dordrecht, Netherlands: D. Reidel; 1986. p. 81.
Shahgheibi S, Rezaie M, Kamangar TM, Zarea S, Yousefi SR. The effect of season on the prevalence of preeclampsia. J Clin Gynecol Obstetr. 2016;5(3):81-4. https://doi.org/10.14740/ jcgo408w
Khader YS, Batieha A, Al-Njadat RA, Hijazi SA. Preeclampsia in Jordan: Incidence, risk factors, and its associated maternal and neonatal outcomes. J Matern Fetal Neonatal Med. 2018;31(6):770- 6. https://doi.org/10.1080/14767058.2017.1297411 PMid:28274172
Ye C, Ruan Y, Zou L, Li G, Li C, Chen Y, et al. The 2011 survey on hypertensive disorders of pregnancy (HDP) in China: Prevalence, risk factors, complications, pregnancy and perinatal outcomes. PLoS One. 2014;9(6):e100180. https://doi. org/10.1371/journal.pone.0100180 PMid:24937406
Bokslag A, Teunissen PW, Franssen C, van Kesteren F, Kamp O, Ganzevoort W, et al. Effect of early-onset preeclampsia on cardiovascular risk in the fifth decade of life. Am J Obstetr Gynecol. 2017;216(5):523. https://doi.org/10.1016/j. ajog.2017.02.015 PMid:28209494
Shao Y, Qiu J, Huang H, Mao B, Dai W, He X, et al. Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: A birth cohort study in Lanzhou, China. BMC Pregnancy Childbirth. 2017;17(1):400. https://doi.org/10.1186/s12884-017-1567-2 PMid:29191156
Lucovnik M, Blickstein I, Verdenik I, Steblovnik L, Bregar AT, Tul N. Impact of pre-gravid body mass index and body mass index change on preeclampsia and gestational diabetes in singleton and twin pregnancies. J Matern Fetal Neonatal Med. 2014;27(18):1901- 4. https://doi.org/10.3109/14767058.2014.892069 PMid:24506066
Omani-Samani R, Ranjbaran M, Amini P, Esmailzadeh A, Sepidarkish M, Almasi-Hashiani A. Adverse maternal and neonatal outcomes in women with preeclampsia in Iran. J Matern Fetal Neonatal Med. 2019;32(2):212-6. https://doi.org/ 10.1080/14767058.2017.1376643 PMid:28871889
Parra-Pingel PE, Quisiguiña-Avellán LA, Hidalgo L, Chedraui P, Pérez-López FR. Pregnancy outcomes in younger and older adolescent mothers with severe preeclampsia. Adolesc Health Med Ther. 2017;8:81. https://doi.org/10.2147/ahmt.s131050 PMid:28652838
Jasim SK. Post cesarean section surgical site infection; incidence and risk factors. Int J Sci Res. 2017;6(7):1864-8. https://doi.org/10.21275/art20175750
Davies EL, Bell JS, Bhattacharya S. Preeclampsia and preterm delivery: A population-based case-control study. Hypertens Pregnancy. 2016;35(4):510-9. https://doi.org/10.1080/1064195 5.2016.1190846 PMid:27322489
Maroufizadeh S, Bagheri LN, Almasi HA, Amini P, Esmaeilzadeh A, Navid B, et al. Prevalence of cesarean section and its related factors among primiparas in Tehran Province, Iran, in 2015. J Isfahan Med Sch 2017;35(423):303-9.
Ray JG, De Souza LR, Park AL, Connelly PW, Bujold E, Berger H. Preeclampsia and preterm birth associated with visceral adiposity in early pregnancy. J Obstetr Gynaecol Can. 2017;39(2):78-81. https://doi.org/10.1016/j.jogc.2016.10.007 PMid:27998690
Sherf Y, Sheiner E, Vardi IS, Sergienko R, Klein J, Bilenko N. Like mother like daughter: Low birth weight and preeclampsia tend to reoccur at the next generation. J Matern Fetal Neonatal Med. 2019;32(9):1478-84. https://doi.org/10.1080/14767058.20 17.1410124 PMid:29172830
Ekubagewargies DT, Kassie DG, Takele WW. Maternal HIV infection and preeclampsia increased risk of low birth weight among newborns delivered at university of Gondar specialized referral hospital, Northwest Ethiopia, 2017. Ital J Pediatr. 2019;45(1):7. https://doi.org/10.1186/s13052-019-0608-z PMid:30630512
Millar LK, Wing DA, Leung AS, Koonings PP, Montoro MN, Mestman JH. Low birth weight and preeclampsia in pregnancies complicated by hyperthyroidism. Obstetr Gynecol. 1994;84(6):946-9. https://doi. org/10.1016/0020-7292(95)94890-r PMid:7970474
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Copyright (c) 2020 Ban Abdulhameed Majeed, Shaymaa Kadhim Jasim, Hayder Al-Momen, Mohammed Jalal Hussein (Author)
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