Correlation between Serum Level of Matrix Metalloproteinase-2 with Left Ventricular End-diastolic Volume in Children with Heart Failure

Authors

  • Bagus Ngurah Mahakrishna Department of Child Health, Medical School, Universitas Udayana, Sanglah Hospital, Denpasar, Bali, Indonesia
  • Eka Gunawijaya Department of Child Health, Medical School, Universitas Udayana, Sanglah Hospital, Denpasar, Bali, Indonesia
  • I Wayan Dharma Artana Department of Child Health, Medical School, Universitas Udayana, Sanglah Hospital, Denpasar, Bali, Indonesia
  • Ni Putu Veny Kartika Yantie Department of Child Health, Medical School, Universitas Udayana, Sanglah Hospital, Denpasar, Bali, Indonesia
  • Made Kardana Department of Child Health, Medical School, Universitas Udayana, Sanglah Hospital, Denpasar, Bali, Indonesia
  • I Putu Gede Karyana Department of Child Health, Medical School, Universitas Udayana, Sanglah Hospital, Denpasar, Bali, Indonesia
  • Gusti Ayu Putu Nilawati Department of Child Health, Medical School, Universitas Udayana, Sanglah Hospital, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.5107

Keywords:

Children, Heart failure, Matrix metalloproteinase 2, Left ventricular end-diastolic volume

Abstract

BACKGROUND: Left ventricular end-diastolic volume (LVEDV) on echocardiography is one of the tests performed on heart failure. This refers to the volume of the left ventricle at the end of the diastolic phase, which would be increased when there is a disturbance in preload, afterload, and contractility factors. Matrix metalloproteinase-2 (MMP2) is a marker of congestive heart failure that can be examined through laboratory examinations.

AIM: The objective of the study was to provide evidence of the association between MMP and inflammatory process as well as its correlation with LVEDV in children with heart failure.

METHODS: This was a cross-sectional study conducted on children aged 3 months–12 years old with heart failure, who visited Sanglah Hospital, Denpasar, Indonesia from May 2017 to March 2018. Echocardiographic examination (LVEDV) and blood samples were taken to measure the serum level of MMP2 on day 1 after the subjects were diagnosed with heart failure.

RESULTS: A total of 32 subjects with heart failure were analyzed in this study. Acyanotic congenital heart defect (CHD) was the most common cause of heart failure, as observed in 23 subjects (71.9%). Characteristics data revealed that 24 subjects (75%) were underweight, 23 (71.9%) had cardiomegaly, and 22 (68.8%) had mild heart failure. Data analysis showed a moderate positive correlation between MMP2 levels with LVEDV after controlling for the influence of age (p = 0.02; r = 0.425).

CONCLUSION: There was a moderate positive correlation between MMP2 level and LVEDV after controlling for the age factor.

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References

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Published

2020-10-19

How to Cite

1.
Mahakrishna BN, Gunawijaya E, Artana IWD, Yantie NPVK, Kardana M, Karyana IPG, Nilawati GAP. Correlation between Serum Level of Matrix Metalloproteinase-2 with Left Ventricular End-diastolic Volume in Children with Heart Failure. Open Access Maced J Med Sci [Internet]. 2020 Oct. 19 [cited 2024 Mar. 29];8(B):973-7. Available from: https://oamjms.eu/index.php/mjms/article/view/5107

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