Stages of BMI, Glucose Control, and Endothelial Cell Activation in Malignancy with Diabetes Patients

Authors

  • Sry Suryani Widjaja Department of Biochemistry, Faculty of Medicine, Universitas of Sumatera Utara, Medan
  • Muhammad Syahputra Department of Biochemistry, Faculty of Medicine, Universitas of Sumatera Utara, Medan
  • Almaycano Ginting Department of Clinical Laboratory, Faculty of Medicine, Universitas of Sumatera Utara, Medan

DOI:

https://doi.org/10.3889/oamjms.2020.5130

Keywords:

Diabetes, Malignancy, Glucose control, Body mass index, Endothelial cell activation

Abstract

BACKGROUND: Abnormalities of glucose metabolism in diabetes can be an independent risk factor for the development and prognosis of cancer; it caused endothelial cell activation, inflammatory reactions. Hemostatic disorders, thrombosis, and various human organ damaged that will increase the morbidity and mortality rate. Diabetes was predicted to reach 552 million by 2030 in conjunction with rapid social and cultural changes. With the changes in lifestyle, body mass index (BMI) plays an important role in increasing the risk of metabolic diseases like diabetes type 2. One sign of endothelial cell activation is an increase in Von Willebrand Factor, which can be an early sign of increased coagulation activation until thrombosis occurs.

AIM: The aim of the study was to determine the correlation between BMI, glucose control, and endothelial cell activation in malignancy with diabetes patients.

METHODS: This is a case-control study with eighty samples. BMI, HbA1C, vWF, and D’dimer were measured.

RESULTS: There is a statistical significant correlation between blood glucose and HbA1C (p = 0.00), blood glucose and BMI (p = 0.037), HbA1C an BMI (p = 0.029), HbA1C and vWF (p = 0.03), HbA1C and age (p = 0.009), D’Dimer and vWF (p = 0.00), and age and BMI (p = −0.019), but no statistical significant between vWF and BMI (p = 0.97), vWF and age (p = 0.36).

CONCLUSIONS: There was an increased risk of thrombosis in malignancy with diabetes cases. BMI showed a significant correlation with blood glucose controlled, blood glucose control showed a significant correlation with the activation of the endothelial cell and hypercoagulable state.

 

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References

Atkins RC, Zimmet P. Diabetic kidney disease: Act now or pay later. Saudi J Kidney Dus Transpl. 2012;21:217-21. PMid:20228503

Peleg AY, Weerarathna T, McCarthy JS, Davis TM. Common infections in diabetes: Pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev. 2007;23:3-13. https://doi.org/10.1002/dmrr.682 PMid:16960917

Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, et al. Diabetes in Asia: Epidemiology, risk factors, and pathophysiology. JAMA. 2009;301:2129-40. https://doi. org/10.1001/jama.2009.726 PMid:19470990

Lam EK, Batty GD, Huxley RR, Martiniuk AL, Barzi F, Lam TH, et al. Associations of diabetes mellitus with site-specific cancer mortality in the Asia-Pacific Region. Ann Oncol. 2011;22:730-8. https://doi.org/10.1093/annonc/mdq405 PMid:20705912

Shikata K, Ninomiya T, Kiyohara Y. Diabetes mellitus and cancer risk: Review of the epidemiological evidence. Cancer Sci. 2013;104:9-14. https://doi.org/10.1111/cas.12043 PMid:23066889

Richardson LC, Pollack LA. Therapy insight: Influence of Type 2 diabetes on the development, treatment and outcomes of cancer. Nat Clin Pract Oncol. 2005;2:48-53. https://doi. org/10.1038/ncponc0062 PMid:16264856

International Diabetes Federation. IDF Diabetes Atlas. 7th ed. Brussels, Belgium: International Diabetes Federation; 2015.

Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414:782-7. https://doi. org/10.1038/414782a PMid:11742409

Hu FB. Globalization of diabetes: The role of diet, lifestyle, and genes. Diabetes Care. 2011;34:1249-57. https://doi. org/10.2337/dc11-0442 PMid:21617109

Creager MA, Lüscher TF, Cosentino F, Beckman JA. Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part I. Circulation. 2003;108:1527-32. https://doi.org/10.1161/01.cir.0000091257.27563.32 PMid:14504252

Reininger AJ. VWF attributes-impact on thrombus formation. Thromb Res. 2008;122:S9-13. https://doi.org/10.1016/ s0049-3848(08)70028-8

Yudkin JS. Abnormalities of coagulation and fibrinolysis in insulin resistance. Evidence for a common antecedent? Diabetes Care. 1999;22:C25-30. PMid:10189559

Hirano T, Ookubo K, Kashiwazaki K, Tajima H, Yoshino G, Adachi M. Vascular endothelial markers, Von Willebrand factor and thrombomodulin index, are specifically elevated in Type 2 diabetic patients with nephropathy: Comparison of primary renal disease. Clin Chim Acta. 2000;299:65-75. https://doi. org/10.1016/s0009-8981(00)00274-6

Blann AD, Lip GY. The endothelium in atherothrombotic disease: Assessment of function, mechanisms and clinical implications. Blood Coagul Fibrinolysis. 1998;9:297-306. https:// doi.org/10.1097/00001721-199806000-00001 PMid:9690800

Horowitz N, Brenner B. Thrombophilia and cancer. Pathophysiol Haemost Thromb. 2008;36:131-6. PMid:19176986

Khorana AA. Venous thromboembolism and prognosis in cancer. Thromb Res. 2010;125:490-3. PMid:20097409

Sheth RA, Hesketh R, Kong DS, Wicky S, Oklu R. Barriers to drug delivery in interventional oncology. J Vasc Interv Radiol. 2013;24:1201-7. https://doi.org/10.1016/j.jvir.2013.03.034 PMid:23735316

Noble S, Pasi J. Epidemiology and pathophysiology of cancer-associated thrombosis. Br J Cancer. 2010;102:S2-9. https://doi. org/10.1038/sj.bjc.6605599 PMid:20386546

Nuttall FQ. Body mass index: Obesity, BMI, and health: A critical review. Nutr Today. 2015;50:117-28. PMid:27340299

Satwanti K, Mungreiphy NK, Rashmi S. Association between BMI, blood pressure, and age: Study among Tangkhul Naga tribal males of Northeast India. J Anthropol. 2011;2011:748147. https://doi.org/10.1155/2011/748147

Neelam A, Mukesh KA, Tannu K, Sunil K. Correlation between body mass index and blood glucose levels in Jharkhand population. Int J Contemp Res. 2017;4:1633-6.

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Published

2020-09-10

How to Cite

1.
Widjaja SS, Syahputra M, Ginting A. Stages of BMI, Glucose Control, and Endothelial Cell Activation in Malignancy with Diabetes Patients. Open Access Maced J Med Sci [Internet]. 2020 Sep. 10 [cited 2024 Feb. 25];8(B):673-5. Available from: https://oamjms.eu/index.php/mjms/article/view/5130

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