The Relation between Lipid Profile and Glycemic Control in Type 2 Diabetes Mellitus Patients in North Sumatera, Indonesia

Authors

  • Rusdiana Rusdiana Department of Biochemistry, Faculty of Medical, Universitas Sumatera Utara, Jl. dr. Mansur Kampus USU Medan 20155, Indonesia http://orcid.org/0000-0002-7308-9291
  • Sry Suryani Widjaja Department of Biochemistry, Faculty of Medical, Universitas Sumatera Utara, Jl. dr. Mansur Kampus USU Medan 20155, Indonesia
  • Maya Savira Department of Physiology, Faculty of Medical, Universitas Sumatera Utara, Jl. dr. Mansur Kampus USU Medan 20155, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.5174

Keywords:

Diabetes Mellitus type 2, blood sugar levels, Hba1c, Lipid profile

Abstract

BACKGROUND: The global prevalence of type 2 diabetes mellitus (DM), a chronic metabolic disorder, has been steadily increasing. Increasing blood sugar levels (BSL) are reliably measured by glycated hemoglobin (HbA1c).

AIM: The aim of this research is to observe the relation between lipid profile with glycemic control at uncontrolled and controlled type 2 DM, early detection of abnormalities in the lipid profile can minimize cardiovascular complication risk in patients with type 2 DM.

METHODS: Collecting medical data record, for example, blood pressure, height and body mass index, duration of disease, family history, and medicine treatment. Laboratory examination such as BSL, HbA1c levels, and lipid profile such as cholesterol, low-density lipoprotein, high-density lipoprotein, and triglycerides (TGs) was evaluated. The study was conducted by implementing cross-sectional methods, among 112 patients with type 2 DM who were admitted from various primary health-care centers in Medan city and the surrounding areas in North Sumatera. The sample criteria are type 2 DM’ patients and both genders. The exclusion criteria of the samples are those with type 1 DM and critical disease.

RESULTS: There is a difference between the average lipid profile level (high-density lipoprotein and TG) in controlled and uncontrolled type 2 DM. Furthermore, there is also a difference between the average HbA1c value in controlled type 2 DM and uncontrolled type 2 DM (p<0.005).

CONCLUSION: This study showed a difference in lipid profile (high-density lipoprotein and TG) and HbA1c between uncontrolled and controlled type 2 DM. Therefore, type 2 DM patients were recommended to undergo periodical glycemic and lipid profile examination control to prevent cardiovascular disease complication.

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References

Abou-Seif MA, Youssef AA. Evaluation of some biochemical changes in diabetic patients. Clin Chim Acta. 2004;346(2):161-170. https://doi.org/10.1016/j.cccn.2004.03.030 PMid:15256317

Berry C, Tardif JC, Bourassa MG. Coronary heart disease in patients with diabetes: Part I: Recent advances in prevention and noninvasive management. J Am Coll Cardiol. 2007;49(6):631-42. PMid:17291928

Jain M, Jadeja JM, Mehta N. Correlation between HbA1c values and lipid profile in Type 2 diabetes mellitus. Int J Basic Appl Physiol. 2013;2(1):47-50.

International Diabetes Federation. About Diabetes. Brussels, Belgium: International Diabetes Federation; 2020. Available from: https://www.idf.org/aboutdiabetes/what-is-diabetes.html. [Last accessed on 2020 Apr 20]. https://doi.org/10.1016/j. diabres.2020.108029

Vinodmahato R, Gyawali P, Psd P, Regmi P, Singh K, Pandeya DR, et al. Association between glycaemic control and serum lipid profile in Type 2 diabetic patients: Glycated haemoglobin as a dual biomarker. Biomed Res. 2011;22(3):375-80.

Samatha P, Prabodh SV, Chowdary NV, Shekhar R. Glycated hemoglobin and serum lipid profile associations in Type 2 diabetes mellitus patients. J Pharm Biomed Sci. 2012;17(12):2230-7885.

Frank B, Stampfer J, Steven M. Elevated risk of cardiovascular disease prior to clinical diagnosis of Type 2 diabetes. Diabetes Care. 2002;25(7):1129-34. PMid:12087009

Khatit M, Quazi S. Risk factors of Type 2 diabetes mellitus in rural Wardha: A community bared study. Int J Diabetes Dev Ctries. 2008;28(3):79-82. https://doi.org/10.4103/0973-3930.44077 PMid:19902039

American Diabetes Association. Standards of medical care in diabetes. Diabetes Care. 2007;30(Suppl 1):S4-41. https://doi. org/10.2337/dc07-s004 PMid:17192377

Joshua A, Becham B, Libby P. Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management. JAMA. 2002;287(19):2570-81. https://doi.org/10.1001/ jama.287.19.2570 PMid:12020339

Sridhar RG. Diabetes in India: Snapshot of a panorama. Curr Sci. 2002;83:1-2.

Analava M, Bhattacharya D, Roy S. Dietary influence on Type 2 diabetes (NIDDM). J Hum Ecol. 2007;21(2):139-47.

Taskinen MR. Diabetic dyslipidaemia: From basic research to clinical practice. Diabetologia. 2003;46(6):733-49. https://doi. org/10.1007/s00125-003-1111-y PMid:12774165

Goldberg IJ. Clinical review 124: Diabetic dyslipidemia: Causes and consequences. J Clin Endocrinol Metab. 2001;8(3):965-71. PMid:11238470

Krauss RM. Lipids and lipoproteins in patients with Type 2 diabetes. Diabetes Care. 2004;27(6):1496-504. https://doi. org/10.2337/diacare.27.6.1496 PMid:15161808

Seshasai SR, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011;364(9):829-41. https://doi.org/10.1056/nejmoa1008862 PMid:21366474

Selvin E, Wattanakit K, Steffes MW, Coresh J, Sharrett AR. HbA1c and peripheral arterial disease in diabetes: The atherosclerosis risk in communities study. Diabetes Care. 2006;29(4):877-82. https://doi.org/10.2337/diacare.29.04.06. dc05-2018 PMid:16567831

Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375(9733):2215-22. https://doi.org/10.1016/ s0140-6736(10)60484-9 PMid:20609967

Amelia R, Damanik HA, Lindarto D, Mutiara E. The correlation between the level of HbA1c with total serum cholesterol of uncontrolled Type 2 diabetes mellitus patients in Binjai, Sumatera Utara. Adv Sci Lett. 2017;23(4):3610-3. https://doi. org/10.1166/asl.2017.9193

Samdani T, Mitra P, Rahim MA. Relationship of glycated haemoglobin with lipid profile among patients with Type 2 diabetes mellitus. BIRDEM Med J. 2017;7(1):43-7. https://doi. org/10.3329/birdem.v7i1.31271

Erciyas F, Taneli F, Arslan B, Uslu Y. Glycemic control, oxidative stress and lipid profile in children with Type 1 diabetes mellitus. Arch Med Res. 2004;35:134-40. https://doi.org/10.1016/j. arcmed.2003.10.002 PMid:15010193

Goldberg IJ. Lipoprotein lipase and lipolysis: Central roles in lipoprotein metabolism and atherogenesis. J Lipid Res. 1996;37(4):693-707. PMid:8732771

Ozder A. Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: A cross-sectional study. Lipids Health Dis. 2014;13:183. https://doi.org/10.1186/1476-511x-13-183

Widjaja SS, Rusdiana R, Savira M. Glucose lowering effect of basil leaves in diabetic rats. Open Access Maced J Med Sci. 2019;7(9):1415-7. https://doi.org/10.3889/oamjms.2019.293 PMid:31198445

Ripsin CM, Kang H, Urban RJ. Management of blood glucose in Type 2 diabetes mellitus. Am Fam Physician. 2009;79(1):29-36. PMid:19145963

Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, et al. The genetic architecture of Type 2 diabetes. Nature. 2016;536:41-7. PMid:27398621

Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, et al. Diet, lifestyle, and the risk of Type 2 diabetes mellitus in women. N Engl J Med. 2001;345(11):790-7. https://doi. org/10.1056/nejmoa010492 PMid:11556298

Schellenberg ES, Dryden DM, Vandermeer B, Ha C, Korownyk C. Lifestyle interventions for patients with and at risk for Type 2 diabetes: A systematic review and meta-analysis. Ann Intern Med. 2013;159(8):543-51. https://doi. org/10.7326/0003-4819-159-8-201310150-00007 PMid:24126648

Sari MI, Sari N, Darlan DM, Prasetya RJ. Cigarette smoking and hyperglycaemia in diabetic patients. Open Access Maced J Med Sci. 2018;6(4):634-7. https://doi.org/10.3889/oamjms.2018.140 PMid:29731929

Wadden TA, West DS, Delahanty L, Jakicic J, Rejeski J, Williamson D, et al. The Look AHEAD study: A description of the lifestyle intervention and the evidence supporting it. Obesity (Silver Spring). 2006;14:737-52. https://doi.org/10.1038/oby.2006.84 PMid:16855180

Centers for Disease Control and Prevention (CDC). Prevalence of overweight and obesity among adults with diagnosed diabetes. United States, 1988-1994 and 1999-2000. MMWR Morb Mortal Wkly Rep. 2004;53(45):1066-8. https://doi.org/10.15585/mmwr. mm6545a4 PMid:15549021

Goldfine AB, Beckman JA. Life and death in Denmark: Lesson about diabetes and coronary heart disease. Circulation. 2008;117:1914-7. https://doi.org/10.1161/ circulationaha.108.767681

Amelia R. The model of self care behavior and the relationship with quality of life, metabolic control and lipid control of Type 2 diabetes mellitus patients in Binjai City, Indonesia. Open Access Maced J Med Sci. 2018;6(9):1762-7. https://doi.org/10.3889/ oamjms.2018.363 PMid:30338004

Amelia R, Ariga RA, Rusdiana, Sari MI, Savira M. Self-efficacy in Type 2 diabetes mellitus patients and the relationship with the quality of life in Medan City. J Phys Conf Ser. 2018;1116(5):052003. https://doi. org/10.1088/1742-6596/1116/5/052003

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Published

2020-10-15

How to Cite

1.
Rusdiana R, Widjaja SS, Savira M. The Relation between Lipid Profile and Glycemic Control in Type 2 Diabetes Mellitus Patients in North Sumatera, Indonesia. Open Access Maced J Med Sci [Internet]. 2020 Oct. 15 [cited 2024 Apr. 26];8(B):887-91. Available from: https://oamjms.eu/index.php/mjms/article/view/5174

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