Susceptibility of Coronavirus Disease-19 in Pediatric Population
DOI:
https://doi.org/10.3889/oamjms.2020.5240Keywords:
Child, Coronavirus disease-19, Risk, SusceptibleAbstract
Since the end of 2019 until present, coronavirus (CoV) disease (COVID)-2019 has spread globally and caused a pandemic. The disease is caused by severe acute respiratory syndrome-2 (SARS-CoV-2). The disease is showed to be less affecting pediatric population. The proportion children suffering from COVID-19 is only around 2% of total cases with only 0.08% mortality rate. Several hypotheses have been proposed regarding this condition. Children are supposed to be less exposed to patients with COVID-19, have lesser amount of angiotensin converting enzyme 2, have different immune response compared to adults, and have faster tissue recovery ability. All of them decrease the possibility of SARS-CoV-2 infection in pediatric population.
Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Ge H, Wang X, Yuan X, Xiao G, Wang C, Deng T, et al. The epidemiology and clinical information about COVID-19. Eur J Clin Microbiol Infect Dis. 2020;39(6):1011-9. https://doi.org/10.1007/s10096-020-03874-z PMid:32291542
Bi Q, Wu Y, Mei S, Ye C, Zou X, Zhang Z, et al. Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: A retrospective cohort study. Lancet Infect Dis. 2020;20(8):911-9. https://doi.org/10.1016/s1473-3099(20)30287-5 PMid:32353347
Musa S. Hepatic and gastrointestinal involvement in coronavirus disease 2019 (COVID-19): What do we know till now? Arab J Gastroenterol. 2020;21(1):3-8. https://doi.org/10.1016/j.ajg.2020.03.002 PMid:32253172
Fan Z, Chen L, Li J, Cheng X, Yang J, Tian C, et al. Clinical features of COVID-19-related liver functional abnormality. Clin Gastroenterol Hepatol. 2020;18(7):1561-6. https://doi.org/10.1016/j.cgh.2020.04.002 PMid:32283325
Cai Q, Huang D, Yu H, Zhu Z, Xia Z, Su Y, et al. COVID-19: Abnormal liver function tests. J Hepatol. 2020;73(3):566-74. https://doi.org/10.1016/j.jhep.2020.04.006 PMid:32298767
Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of cronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;109:102433. https://doi.org/10.1016/j.jaut.2020.102433 PMid:32113704
Liguoro I, Pilotto C, Bonanni M, Ferrari ME, Pusiol A, Nocerino A, et al. SARS-COV-2 infection in children and newborns: A systematic review. Eur J Pediatr. 2020;179(7):1029-46. https://doi.org/10.1007/s00431-020-03684-7 PMid:32424745
Jeng M. Coronavirus disease 2019 in children: Current status. J Chin Med Assoc. 2020;83(6):527-33. https://doi.org/10.1097/jcma.0000000000000323 PMid:32502117
Lyu J, Miao T, Dong J, Cao R, Li Y, Chen Q. Reflection on lower rates of COVID-19 in children: Does childhood immunizations offer unexpected protection? Med Hypotheses. 2020;143:109842. https://doi.org/10.1016/j.mehy.2020.109842 PMid:32425304
Cheung KS, Hung IF, Chan PP, Lung K, Tso E, Liu R, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis. Gastroenterology. 2020;159(1):81-95. https://doi.org/10.1053/j.gastro.2020.03.065 PMid:32251668
Zhang C, Shi L, Wang F. Liver injury in COVID-19: Management and challenges. Lancet Gastroenterol Hepatol. 2020;5:428-30. https://doi.org/10.1016/s2468-1253(20)30057-1 PMid:32145190
Xudong X, Junzhu C, Xingxiang W, Furong Z, Yanrong L. Age and gender-related difference of ACE2 expression in rat lung. Life Sci. 2006;78(19):2166-71. https://doi.org/10.1016/j.lfs.2005.09.038 PMid:16303146
Zhang X. Epidemiology of Covid-19. N Engl J Med. 2020;382(19);1869-70. https://doi.org/10.1056/nejmc200515 PMid:32220200
Lee P, Hu Y, Chen P, Huang Y, Hsueh P. Are children less susceptible to COVID-19? J Microbiol Immunol Infect. 2020;53(3):371-2. https://doi.org/10.1016/j.jmii.2020.02.011 PMid:32147409
Fischer A. Resistance of children to Covid-19. How? Mucosal Immunol. 2020;13:563-5. https://doi.org/10.1038/ s41385-020-0303-9
Simon AK, Hollande GA, McMichael A. Evolution of the immune system in humans from infancy to old age. Proc Bio Soc. 2015;282(1821):20143085. https://doi.org/10.1098/rspb.2014.3085 PMid:26702035
Georgountzou A, Papadopoulos NG. Postnatal innate immune development: From birth to adulthood. Front Immunol. 2017;8:957. https://doi.org/10.3389/fimmu.2017.00957 PMid:28848557
Prendergast AJ, Klenerman P, Goulder PJR. The impact of differential antiviral immunity in children and adults. Nat Rev Immunol. 2012;12(9):636-48. https://doi.org/10.1038/nri3277
PMid:22918466
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2020 Riska Habriel Ruslie, Darmadi Darmadi, Gontar Alamsyah Siregar (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0