Pre-operative Neutrophil-to-Lymphocyte Ratio is Associated with Post-operative Opioid Requirements and Length of Stay after Thoracotomy

Authors

  • I Wayan Suranadi Department of Anesthesiology and Intensive Care, Faculty of Medicine, Udayana University, Bali, Indonesia
  • Tjokorda Gde Agung Senapathi Department of Anesthesiology and Intensive Care, Faculty of Medicine, Udayana University, Bali, Indonesia
  • Ayu Dilia Febriani Wisnawa Department of Anesthesiology and Intensive Care, Faculty of Medicine, Udayana University, Bali, Indonesia
  • Christopher Ryalino Department of Anesthesiology and Intensive Care, Faculty of Medicine, Udayana University, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.5300

Keywords:

Neutrophil-to-lymphocyte ratio, Analgesics, Length of stay, Thoracotomy

Abstract

BACKGROUND: Surgical pain and prolonged hospital length of stay (LOS) affect a large proportion of patients after thoracotomy. Inflammation plays a crucial role in the mechanism and progression of pain and the outcomes.

AIM: The objective of this study was to investigate the association between the pre-operative neutrophil-to-lymphocyte ratio (NLR) and post-operative pain and LOS in patients undergoing thoracotomy.

METHODS: This was a retrospective, observational study on 157 patients who underwent thoracotomy under general anesthesia. We classified the subjects into two study groups: Group with for patients with NLR <2 and Group 2 for NLR ≥2. We measured the post-operative pain by gathering the data of post-operative opioid needs. We used Pearson’s and Spearman’s correlation tests to assess the association of the parameters.

RESULTS: The mean of total oral morphine equivalent in the first 48 h following thoracotomy in Group 1 was 140.8 ± 60.4 mg compared to Group 2’s 109.7 ± 55.8 (p < 0.05). The median hospital’s LOS was longer in Group 2 compared to Group 1 (7 vs. 10, p < 0.001). We found a weak positive correlation between pre-operative NLR (R = 0.267, p = 0.002) and post-operative opioid requirements, and a weak positive correlation between pre-operative NLR and the hospital’s LOS (R = 0.345, p < 0.001).

CONCLUSION: Pre-operative NLR correlates with post-operative opioid requirements and the time hospital’s LOS in patients who underwent elective thoracotomy.

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Published

2020-10-11

How to Cite

1.
Suranadi IW, Senapathi TGA, Wisnawa ADF, Ryalino C. Pre-operative Neutrophil-to-Lymphocyte Ratio is Associated with Post-operative Opioid Requirements and Length of Stay after Thoracotomy. Open Access Maced J Med Sci [Internet]. 2020 Oct. 11 [cited 2024 Mar. 29];8(B):1000-4. Available from: https://oamjms.eu/index.php/mjms/article/view/5300

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