Efficacy of Albendazole and Albendazole-Mebendazole against Trichuris trichiura Infections

Erwin Suteno; Ayodhia Pitaloka Pasaribu; Nirmalia Husin; Willhans Wijaya; Syahril Pasaribu

doi:10.3889/oamjms.2020.5329

Authors

Erwin Suteno Department of Child Health, Medical Faculty, Universitas Sumatera Utara, Medan Baru, Medan, North Sumatera
Ayodhia Pitaloka Pasaribu Department of Child Health, Medical Faculty, Universitas Sumatera Utara, Medan Baru, Medan, North Sumatera
Nirmalia Husin Department of Child Health, Medical Faculty, Universitas Sumatera Utara, Medan Baru, Medan, North Sumatera
Willhans Wijaya Department of Child Health, Medical Faculty, Universitas Sumatera Utara, Medan Baru, Medan, North Sumatera
Syahril Pasaribu Department of Child Health, Medical Faculty, Universitas Sumatera Utara, Medan Baru, Medan, North Sumatera

DOI:

https://doi.org/10.3889/oamjms.2020.5329

Keywords:

Efficacy, T. trichiura, Albendazole, Mebendazole, Primary school children

Abstract

BACKGROUND: Trichuris trichiura infections treatment using albendazole or mebendazole as a single dose is rated unsatisfactory. The combination of albendazole-mebendazole is viewed to have better efficacy against T. trichiura infections due to the nature of each drug.

AIM: This study compared the efficacy of albendazole and albendazole-mebendazole for T. trichiura infection treatment in Talawi, Batu Bara, North Sumatra, among primary school children.

METHODS: An open randomized clinical trial was carried out in Talawi, Batu Bara. The efficacy of albendazole as a single dose and albendazole-mebendazole as a single dose was compared. Research subjects were school children aged 6–12 years old with T. trichiura infections. Chi-square test was performed to compare the cure rate and unpaired t-test was done to compare the number of eggs per gram (epg) in both groups.

RESULTS: From a total of 463 children, 235 of them suffered from T. trichiura infections. The cure rate of the group with 400 mg albendazole as a single dose was 52.5%, while the other group with albendazole 400 mg – mebendazole 500 mg as a single dose was at 71.1% cure rate. The cure rate of the two groups showed a significant difference with p = 0.011. Both groups were observed to have a significant reduction in the number worm eggs with p = 0.04.

CONCLUSION: Albendazole 400 mg – mebendazole 500 mg combination as a single dose treatment has better efficacy than albendazole 400 mg alone, where the drug combination gave a higher cure rate and greater reduction in the number of T. trichiura eggs.

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