Chemical Mutagenesis and Cytogenetic Chromosomal Abnormalities in a Population Living in the Aral Sea region

Zhanbol Sabirov; Zulkiya Namazbaeva; Sharbanu  Battakova; Maral   Otarbayeva; Manara Mukasheva; Aliya Eshmagambetova

doi:10.3889/oamjms.2020.5345

Authors

Zhanbol Sabirov The scientific-research sanitary-hygienic laboratory of the Institute of Public Health and Professional Health, NC JSC “MUK”, Karagandy, Kazakhstan; Department of Physiology, NC JSC Karaganda University named after Academician E.A. Buketova, Karagandy, Kazakhstan
Zulkiya Namazbaeva The scientific-research sanitary-hygienic laboratory of the Institute of Public Health and Professional Health, NC JSC “MUK”, Karagandy, Kazakhstan
Sharbanu Battakova The scientific-research sanitary-hygienic laboratory of the Institute of Public Health and Professional Health, NC JSC “MUK”, Karagandy, Kazakhstan
Maral Otarbayeva The scientific-research sanitary-hygienic laboratory of the Institute of Public Health and Professional Health, NC JSC “MUK”, Karagandy, Kazakhstan
Manara Mukasheva Department of Physiology, NC JSC Karaganda University named after Academician E.A. Buketova, Karagandy, Kazakhstan
Aliya Eshmagambetova Department of Physiology, NC JSC Karaganda University named after Academician E.A. Buketova, Karagandy, Kazakhstan

DOI:

https://doi.org/10.3889/oamjms.2020.5345

Keywords:

DNA, Chromosomal aberrations, Heavy metals, Genotoxicity, Mutagenesis, Ecology, Aral sea region

Abstract

AIM: The article presents the results of a study of chromosomal mutations in residents living in the Aral Sea disaster zone, using the example of the city of Aralsk.

METHODS: The article identifies the level of chromosomal aberrations (CA) in the surveyed population and identifies the leading type of aberrations in this region.

RESULTS: Researches have shown that the main types of structural changes were chromatid breaks and single fragments of chromosomes. The results showed that in the study population, the microelement status indicates an imbalance of microelements. A correlation analysis showed a relationship between the nickel content in the blood and the increase in CAs. Furthermore, researches show a hypothesis about the pathogenesis mechanism of the formation of CAs.

CONCLUSION: Thus, the article provides information on chromosomal mutations during chemical mutagenesis.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Prss-Ustn A, Wolf J, Corvaln C, Bos R, Neira M. Preventing Disease Through Healthy Environments: A Global Assessment of the Burden of Disease from Environmental Risks. Geneva: World Health Organization; 2016. Available from: https://www.apps.who.int/iris/ bitstream/ handle/10665/204585/9789241565196_eng.pdf;jsessionid=D7 D004ED726D3267C2796D2672738E64?sequence=1. https:// doi.org/10.1016/j.toxlet.2016.07.028

World Health Organization. A Global Brief on Vector-borne Diseases. Geneva: World Health Organization; 2014. Available from: https://www.apps.who.int/iris/bitstream/handle/ 10665/111008/WHO_DCO_WHD_2014.1_eng.pdf?sequence=1.

Wolf J, Prüss-Ustün A, Cumming O, Bartram J, Bonjour S, Cairncross S, et al. Assessing the impact of drinking water and sanitation on diarrhoeal disease in low-and middle-income settings: Systematic review and meta-regression. Trop Med Int Health. 2014;19(8):928-42. https://doi.org/10.1111/tmi.12331 PMid:24811732

Hou L, Wang D, Baccarelli A. Environmental chemicals and microRNAs. Mutat Res. 2011;714(1-2):105-12. https://doi. org/10.1016/j.mrfmmm.2011.05.004 PMid:21609724

Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal toxicity and the environment. In: Molecular, Clinical and Environmental Toxicology. Basel: Springer; 2012. p. 133-64. https://doi.org/10.1007/978-3-7643-8340-4_6

Sakiev K, Battakova S, Namazbaeva Z, Ibrayeva L, Otarbayeva M, Sabirov Z. Neuropsychological state of the population living in the Aral Sea region (zone of ecological crisis). Int J Occup Environ Health. 2017;23(2):87-93. https:// doi.org/10.1080/10773525.2018.1425655 PMid:29359636

Namazbaeva Z, Battakova S, Ibrayeva L, Sabirov Z. Change in metabolic and cognitive state among people of the Aral zone of ecological disaster. Israel J Ecol Evol. 2018;64(1-4):44-55. https://doi.org/10.1163/22244662-20181035

Ataniyazova OA, Baumann RA, Liem AK, Mukhopadhyay UA, Vogelaar EF, Boersma ER. Levels of certain metals, organochlorine pesticides and dioxins in cord blood, maternal blood, human milk and some commonly used nutrients in the surroundings of the Aral Sea (Karakalpakstan, republic of Uzbekistan). Acta Paediatr. 2001;90(7):801-8. https://doi. org/10.1111/j.1651-2227.2001.tb02808.x PMid:11519985

Hashizume M, Kunii O, Sasaki S, Shimoda T, Wakai S, Mazhitova Z, et al. Anemia and iron deficiency among schoolchildren in the Aral Sea region, Kazakhstan. J Trop Pediatr. 2003;49(3):172-7. https://doi.org/10.1093/tropej/49.3.172 PMid:12848209

Erdinger L, Eckl P, Ingel F, Khussainova S, Utegenova E, Mann V, et al. The Aral Sea disaster-human biomonitoring of Hg, As, HCB, DDE, and PCBs in children living in Aralsk and Akchi, Kazakhstan. Int J Hyg Environ Health. 2004;207(6):541- 7. https://doi.org/10.1078/1438-4639-00325

Kaneko K, Chiba M, Hashizume M, Kunii O, Sasaki S, Shimoda T, et al. Renal tubular dysfunction in children living in the Aral Sea region. Arch Dis Childhood. 2003;88(11):966-8. https://doi.org/10.1136/adc.88.11.966

Shamsiyev AM, Khusinova SA. The influence of environmental factors on human health in Uzbekistan. In: The Socioeconomic Causes and Consequences of Desertification in Central Asia. Dordrecht: Springer; 2008. p. 249-52. https://doi. org/10.1007/978-1-4020-8544-4_11

Au WW, Ruchirawat M. Biomarkers in population studies: Environmental mutagenesis and risk forcancer. Rev Environ Heath. 2009;24(2):17-27. PMid:19658318

Garsed DW, Marshall OJ, Corbin VD, Hsu A, Di Stefano L, Schröder J, et al. The architecture and evolution of cancer neochromosomes. Cancer Cell. 2014;26(5):653-67. https://doi. org/10.1016/j.ccell.2014.09.010 PMid:25517748

Kurtcer MA, Gnetestskaya VA, Mitkin VV, Kalinovskaya II, Kutakova YU. The results of prenatal screening for chromosomal pathology in Moscow. Obstetr Gynecol. 2010;3:32-5.

Kumsta C, Chang JT, Schmalz J, Hansen M. Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. Elegans. Nat Commun. 2017;8:1-12. https:// doi.org/10.1038/ncomms14337 PMid:28198373

Kolotiy AD, Vorsanova SG, Yurov YI, Demidova IA, BereshevaAK. Cytogenetic and molecular cytogenetic investigations in the diagnosis of mosaic forms of chromosomal abnormalities in children. Russ Bull Perinatol Pediatr. 2011;2:23-9. Available from: https://www.cyberleninka.ru/article/n/tsitogeneticheskie-imolekulyarno-tsitogeneticheskie-issledovaniya-v-diagnostikemozaichnyh-form-hromosomnyh-anomaliy-u-detey.

Sycheva LP, Ivanov SI, Kovalenko MA, Zhurkov VS, Belyaeva NN, Antsiferov BM. The cytogenetic status of children living in the vicinity of a pulp-and-paper mill. Gig Sanit. 2010;1:7-10. PMid:20373705

Bequette F. The Sea’s dwindling harvest. UNESCO Courier. 1994;12:41-4. Available from: https://www.questia.com/ magazine/1G1-16476565/the-sea-s-dwindling-harvest.

Nazhmetdinova AS, Sarmanbetova GK. Risk assessment under the influence of persistent organic pollutants (pops) and heavy metals on the population of the Aral Sea region. Mod Probl Sci Educ. 2016;6:127-37.

Lioubimtseva E. A multi-scale assessment of human vulnerability to climate change in the Aral Sea basin. Environ Earth Sci. 2015;73(2):719-29. https://doi.org/10.1007/s12665-014-3104-1

Zhang W, Ma L, Abuduwaili J, Ge Y, Issanova G, Saparov G. Distribution characteristics and assessment of heavy metals in the surface water of the Syr Darya River, Kazakhstan. Polish J Environ Stud. 2019;29(1):979-88. https://doi.org/10.15244/ pjoes/104357

Sаkiev KZ, Ibrayeva LK, Spirin VF, Оtаrbаyevа MB, Grebenеvа OV. Assessment of polluting factors of atmospheric air in arid areas in the warm season. Public Health and Life Environ. 2016;9(282):53-5.

Moorhead PS, Nowell PS, Mellman WJ, Battips DT, Hungerford DA. Chromosome preparation of leukocytes cultured from human peripheral blood. Exp Cell Res. 1960;20(3):613-6. https://doi.org/10.1016/0014-4827(60)90138-5 PMid:13772379

Hungerford DA. Leukocytes cultured from small inocula of whole blood and the preparation of metaphase chromosomes by treatment with hypotonic KCl. Stain Technol. 1965;40(6):333-8. https://doi.org/10.3109/10520296509116440 PMid:5866557

Sabirov JB, Namazbayeva ZI, Ibraeva LK, Zhanbasinova NM. The use of cytogenetic method of accounting for chromosomal aberrations for the study of mutagenicity in an unfavorable ecological situation. Occup Hyg Med Ecol. 2017;4(57):65-88.

Goloshchapov AP. Genetic and Biochemical Aspects of Human Adaptation to the Conditions of the City with Developed Chemical Industry. Moscow: Association of Scientific Publications KMK; 2012. Available from: https://www.books. google.kz/books?hl=ru&lr&id=dBdfDwAAQBAJ&oi=fnd&pg=P A4&dq=Голощапов+А.П.+Генетико-биохимические+аспект ы+адаптации+человека+к+условиям+города+с+развитой+ химической +промышленностью.+–+М.:+Товарищест&ots= NraMFSBI0p&sig=B10uv1eV_N_J5c1B2MiS7hLTOHI&redir_ esc=y&pli=1&authuser=1#v=onepage&q=Голощап ов%20 А.П.%20Генетико-биохимические%20аспекты%20 адаптации%20человека%20к%20условиям%20 города%20с%20развитой%20химической%20 промышленностью.%20–% 20М.%3A%20 Товарищест&f=false.

Hoa NT, Trubnikova EV, Komkova GV, Zheleznova MA, Radionova MA, Shulgin I. Comparative analysis of the level of spontaneed mutagenesis in residents of Zheleznogorsky district in 2018. Int J Genomics. 2019;1(1):22-5. https://doi. org/10.32743/2658-6460.2019.1.1.40

Kharchenko TV, Arjavkina LG, Yazenok AV, Siniachkin DA, Zhekalov AN. Genotoxic alterations in the personnel of chemical stockpile disposal facilities. Toxicol Rev 2016;138(3):36-40.

Buckton KE, Evans HJ. Methods for the Analysis of Human Chromosome Aberrations. Geneva: World Health Organization; 1973.

World Health Organization. International Commission for Protection against Environmental Mutagens and Carcinogens. Guide to Short-term Tests for Detecting Mutagenic and Carcinogenic Chemicals. Geneva: World Health Organization; 1985. p. 101. Available fronm: https://www.apps.who.int/iris/ bitstream/ handle/10665/38607/9241541911-corr-eng.pdf? sequence=1&isAllowed=y.

Sabirov ZB. Ways of occurrence of structural mutations in the chemical nature of mutagenesis. Occup Hyg Med Ecol 2015;2(47):26-31.

Diss G, Gagnon-Arsenault I, Dion-Coté AM, Vignaud H, Ascencio DI, Berger CM, et al. Gene duplication can impart fragility, not robustness, in the yeast protein interaction network. Science. 2017;355(6325):630-4. https://doi.org/10.1126/ science.aai7685 PMid:28183979

Sevan’kaev AV, Khvostunov IK, Lloyd DC, Voisen PH, Golub EV, Nadejina NM, et al. The suitability of FISH chromosome painting and ESR-spectroscopy of tooth enamel assays for retrospective dose reconstruction. J Radiat Res. 2006;47:A75-80. https://doi. org/10.1269/jrr.47.a75

Hagmar L, Bonassi S, Stromberg U, Brøgger A, Knudsen LE, Norppa H, et al. Chromosomal aberrations in lymphocytes predict human cancer: A report from the European study group on cytogenetic biomarkers and health (ESCH). Cancer Res. 1998;58(18):4117-21. https://doi.org/10.1016/ s0027-5107(98)00134-1 PMid:9751622

Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A. Biomarkers of oxidative damage in human disease. Clin Chem. 2006;52(4):601-23. https://doi.org/10.1373/ clinchem.2005.061408 PMid:16484333

Prodanchuk NG, Balan GM. The toxic effects of xenobiotics on stem cells as a risk factor for the development of general and oncological diseases. Mod Probl Toxicol 2010;1(48):17-41.

Puchkova AO, Kasyanenko NA. The investigation of DNA interaction with metal ions in presence of catechin, epicathechin and caffeine. Vestnik of Saint Petersburg university. Physics Chem. 2011;2:96-102.

Cortés-Eslava J, Gómez-Arroyo S, Risueño MC, Testillano PS. The effects of organophosphorus insecticides and heavy metals on DNA damage and programmed cell death in two plant models. Environ Pollut. 2018;240:77-86. https://doi. org/10.1016/j.envpol.2018.04.119 PMid:29729572

Nersesyan A, Kundi M, Mišík M, Wultsch G, Knasmueller S. Heavy metals-lead, mercury and cadmium and their impact on DNA damage measured by the micronucleus assay. In: The Micronucleus Assay in Toxicology. London: Royal Society of Chemistry; 2019. p. 435-49. https://doi. org/10.1039/9781788013604-00435

Morales ME, Derbes RS, Ade CM, Ortego JC, Stark J, Deininger PL, et al. Heavy metal exposure influences double strand break DNA repair outcomes. PLoS One. 2016;11(3):e0151367. https://doi.org/10.1371/journal. pone.0151367 PMid:26966913

Blagoi YP. DNA interaction with biologically active substances (metal ions, dyes, drugs). Soros Educ J. 1998;10(35):18-25.

Khlebodarova TM, Oshchepkov DY, Levitsky VG, Podkolodnaya OA, Ignatieva EV, Ananko EA, et al. Effect of flanking sequences on the accuracy of the recognition of transcription factor binding sites. Vavilov J Genet Breed. 2014;18(4/2):876-86. https://doi.org/10.1134/ s2079059715040073

Nemec AA, Wallace SS, Sweasy JB. Variant base excision repair proteins: Contributors to genomic instability. Semin Cancer Biol. 2010;20(5):320-8. https://doi.org/10.1016/j. semcancer.2010.10.010 PMid:20955798