An Old Therapy, Convalescent Plasma, for Coronavirus Disease-19: Do We Have All the Answer?

Authors

  • Ahmad Faried Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia; Stem Cell Unit, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia; Convalescent Plasma Therapy for COVID-19 Team, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
  • Wahyu Widowati Department of Biology, Faculty of Medicine, Maranatha Christian University, Bandung, West Java, Indonesia
  • Ruswana Anwar Convalescent Plasma Therapy for COVID-19 Team, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
  • Nucki Nursjamsi Hidajat Stem Cell Unit, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
  • Ali Budi Harsono Stem Cell Unit, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
  • Yulius Hermanto Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia; Stem Cell Unit, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
  • Alya Mardhotillah Azizah Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung, West Java, Indonesia
  • Jenifer Kiem Aviani Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung, West Java, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.5462

Keywords:

Coronavirus disease-19, Severe acute respiratory syndrome-coronavirus-2, Passive immunization, Convalescent plasma therapy

Abstract

BACKGROUND: Coronavirus (CoV) disease (COVID-19) has become a global health pandemic by early 2020; it has pushed the health-care system to its limit. From the initial estimates, 15% of COVID-19 patients caused by severe acute respiratory CoV 2 syndrome present with severe symptoms and requires hospitalization or even intensive care. There is no specific treatment against COVID-19, particularly for those with severe symptoms. Desperation caused by COVID-19 has driven clinicians to try an alternative therapies with little or even no-evidence previously. Convalescent plasma therapy (CPT) has emerged as a promising COVID-19 therapy.

AIM: We aimed to review current state of convalescent plasma therapy.

METHODS: We summarize the historical CPT, COVID-19 pathology and evaluate potential of CPT for COVID-19; raising the question regarding routinely administrating CPT to the COVID-19 patients, whether it is safe and effective.

RESULTS: From cases in Indonesia and other countries, there is bunch of examples that healthcare workers being negatively stigmatized in case of COVID-19. They lost their rights to have a normal life in this pandemic era. A reasonable basis is found in many literatures to advocate the CPT. Convalescent plasma from COVID-19 patients who had been recovered with high neutralizing antibody titers was reported to be effective on transfusion to other COVID-19 patients.

CONCLUSION: CPT is one good option to treat COVID-19 patients, but it not without risk; many potential candidate treatment that promising in theory but somehow fall apart when translated into clinical study; only time will tell, including our ongoing CPT clinical study.

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2020-11-14

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Faried A, Widowati W, Anwar R, Hidajat NN, Harsono AB, Hermanto Y, Azizah AM, Aviani JK. An Old Therapy, Convalescent Plasma, for Coronavirus Disease-19: Do We Have All the Answer?. Open Access Maced J Med Sci [Internet]. 2020 Nov. 14 [cited 2024 May 26];8(T1):530-7. Available from: https://oamjms.eu/index.php/mjms/article/view/5462

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