The Effectiveness of Probiotics against Viral Infections: A Rapid Review with Focus on SARS-CoV-2 Infection


  • Jehan Abdul-Sattar Salman Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
  • Nibras Nazar Mahmood Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
  • Ban Oday Abdulsattar Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
  • Hussein Adil Abid Department of Medical Laboratory Technology, Technical Institute of Baquba, Middle Technical University, Baqubah, 32001, Iraq



Adjunctive therapy, Bifidobacterium, COVID-19, Lactobacillus, Probiotics


Viral infections have gained great attention following the rapid emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic around the globe. Even with the continuous research on developing vaccines and antiviral agents against various viral infections, no specific treatment or vaccine has been approved for many enteric or respiratory viral infections; in addition, the efficiency of currently available treatments is still limited. One of the most reliable and recommended strategies to control viral infections is prevention. Recently, intense studies are focusing on a promising approach for treating/preventing various viral infections using probiotics. As per the World Health Organization (WHO), probiotics can be defined as “live microorganisms which, when administered in adequate amount, confer a health benefit to the host.” The use of probiotics is a simple, cost-effective, and safe strategy to prevent viral infections, specifically; respiratory tract and intestinal ones, by different means such as stimulating the host’s immune response or modulating gut microbiota. In this rapid review, we emphasize the protective effects of probiotics against viral infections and proposed mechanisms for protection that might offer a novel and cost-effective treatment against current and newly discovered viruses like SARS-CoV-2.


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Metchnikoff E. Prolongation of Life, Optimistic Studies. New York, London: Putman’s Sons; 1908.

Kollath W. Nutrition and the tooth system; general review with special reference to vitamins. Dtsch Zahnarztl Z 1953;8(11):Suppl 7-16. PMid:13068115

Lilly DM, Stillwell RH. Probiotics: Growth-promoting factors produced by microorganisms. Science 1965;147(3659):747-8. PMid:14242024

World Health Organization. Evaluation of Certain Food Additives and Contaminants. 57th Report of the Joint FAO/WHO Expert Committee on Food Additives. Geneva, Switzerland: Biosphere Health Organization; 2002.

Sharifi-Rad J, Rodrigues CF, Stojanović-Radić Z, Dimitrijević M, Aleksić A, Neffe-Skocińska K, et al. Probiotics: Versatile bioactive components in promoting human health. Medicina (Kaunas) 2020;56(9):433. PMid:32867260

Osvath R. FDA’s food advisory committee to discuss criteria for safety of probiotics. Food Chem News 2000;42:12.

Bhattacharyya BK. Emergence of probiotics in therapeutic applications. Int J Pharm Sci Nanotechnol 2009;2(1):383-9.

Jahanshahi M, Dana PM, Badehnoosh B, Asemi Z, Hallajzadeh J, Mansournia MA, et al. Anti-tumor activities of probiotics in cervical cancer. J Ovarian Res 2020;13(1):68. PMid:32527332

Kos B, Šušković J, Vuković S, Sǐmpraga M, Frece J, Matošić S. Adhesion and aggregation ability of probiotic strain Lactobacillus acidophilus M92. J Appl Microbiol 2003;94(6):981-7. PMid:12752805

Aly SM, Ahmed YA, Ghareeb AA, Mohamed MF. Studies on Bacillus subtilis and Lactobacillus acidophilus, as potential probiotics, on the immune response and resistance of Tilapia nilotica (Oreochromis niloticus) to challenge infections. Fish Shellfish Immunol 2008;25(1-2):128-36. PMid:18450477

Bull M, Plummer S, Marchesi J, Mahenthiralingam E. The life history of Lactobacillus acidophilus as a probiotic: A tale of revisionary taxonomy, misidentification and commercial success. FEMS Microbiol Lett 2013;349(2):77-87. PMid:24152174

Andreasen AS, Larsen N, Pedersen-Skovsgaard T, Berg RM, Møller K, Svendsen KD, et al. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr 2010;104(12):1831-8. PMid:20815975

Kim SJ, Cho SY, Kim SH, Song OJ, Shin IS, Cha DS, et al. Effect of microencapsulation on viability and other characteristics in Lactobacillus acidophilus ATCC 43121. LWT Food Sci Technol 2008;41(3):493-500.

Ng EW, Yeung M, Tong PS. Effects of yogurt starter cultures on the survival of Lactobacillus acidophilus. Int J Food Microbiol 2011;145(1):169-75. PMid:21196060

Klein G, Pack A, Bonaparte C, Reuter G. Taxonomy and physiology of probiotic lactic acid bacteria. Int J Food Microbiol 1998;41(2):103-25. PMid:9704860

Phillips M, Kailasapathy K, Tran L. Viability of commercial probiotic cultures (L. acidophilus, Bifidobacterium sp., L. casei, L. paracasei and L. rhamnosus) in cheddar cheese. Int J Food Microbiol 2006;108(2):276-80. PMid:16478637

Yaeshima T, Takahashi S, Ishibashi N, Shimamura S. Identification of bifidobacteria from dairy products and evaluation of a microplate hybridization method. Int J Food Microbiol 1996;30(3):303-13. PMid:8854183

Groeger D, O’Mahony L, Murphy EF, Bourke JF, Dinan TG, Kiely B, et al. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes 2013;4(4):325-39. PMid:23842110

O’Mahony D, Murphy S, Boileau T, Park J, O’Brien F, Groeger D, et al. Bifidobacterium animalis AHC7 protects against pathogeninduced NF-κB activation in vivo. BMC Immunol 2010;11(1):63. PMid:21176205

Strozzi GP, Mogna L. Quantification of folic acid in human feces after administration of Bifidobacterium probiotic strains. J Clin Gastroenterol 2008;42(Suppl 3 Pt 2):S179-84. PMid:18685499

Quigley EM. Bifidobacterium longum. In: The Microbiota in Gastrointestinal Pathophysiology. Amsterdam, Netherlands: Elsevier; 2017. p. 139-41.

Tanner SA, Chassard C, Zihler Berner A, Lacroix C. Synergistic effects of Bifidobacterium thermophilum RBL67 and selected prebiotics on inhibition of Salmonella colonization in the swine proximal colon PolyFermS model. Gut Pathog 2014;6(1):44. PMid:25364390

Nueno-Palop C, Narbad A. Probiotic assessment of Enterococcus faecalis CP58 isolated from human gut. Int J Food Microbiol 2011;145(2-3):390-4. PMid:21315470

Simpson KW, Rishniw M, Bellosa M, Liotta J, Lucio A, Baumgart M, et al. Influence of Enterococcus faecium SF68 probiotic on giardiasis in dogs. J Vet Intern Med 2009;23(3):476-81. PMid:19298607

Kimoto H, Kurisaki J, Tsuji NM, Ohmomo S, Okamoto T. Lactococci as probiotic strains: Adhesion to human enterocyte-like Caco-2 cells and tolerance to low pH and bile. Lett Appl Microbiol 1999;29(5):313-6. PMid:10664972

Mao N, Cubillos-Ruiz A, Cameron DE, Collins JJ. Probiotic strains detect and suppress cholera in mice. Sci Transl Med 2018;10(445):eaao2586. PMid:29899022

Daba H, Pandian S, Gosselin JF, Simard RE, Huang J, Lacroix C. Detection and activity of a bacteriocin produced by Leuconostoc mesenteroides. Appl Environ Microbiol 1991;57(12):3450-5. PMid:1785922

Barbosa J, Borges S, Teixeira P. Pediococcus acidilactici as a potential probiotic to be used in food industry. Int J Food Sci Technol 2015;50(5):1151-7.

Huang HY, Huang SY, Chen PY, King VA, Lin YP, Tsen JH. Basic characteristics of Sporolactobacillus inulinus BCRC 14647 for potential probiotic properties. Curr Microbiol 2007;54(5):396-404. PMid:17387552

Uriot O, Denis S, Junjua M, Roussel Y, Dary-Mourot A, Blanquet-Diot S. Streptococcus thermophilus: From yogurt starter to a new promising probiotic candidate? J Funct Foods 2017;37:74-89.

Duc LH, Hong HA, Barbosa TM, Henriques AO, Cutting SM. Characterization of Bacillus probiotics available for human use. Appl Environ Microbiol 2004;70(4):2161-71. PMid:15066809

Hong HA, Huang JM, Khaneja R, Hiep LV, Urdaci MC, Cutting SM. The safety of Bacillus subtilis and Bacillus indicus as food probiotics. J Appl Microbiol 2008;105(2):510-20. PMid:18312567

Altenhoefer A, Oswald S, Sonnenborn U, Enders C, Schulze J, Hacker J, et al. The probiotic Escherichia coli strain Nissle 1917 interferes with invasion of human intestinal epithelial cells by different enteroinvasive bacterial pathogens. FEMS Immunol Med Microbiol 2004;40(3):223-9. PMid:15039098

Hwang IY, Koh E, Wong A, March JC, Bentley WE, Lee YS, et al. Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models. Nat Commun 2017;8(1):15028. PMid:28398304

Cousin FJ, Jouan-Lanhouet S, Théret N, Brenner C, Jouan E, Le Moigne-Muller G, et al. The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer. Oncotarget 2016;7(6):7161-78. PMid:26771233

Pontier-Bres R, Prodon F, Munro P, Rampal P, Lemichez E, Peyron JF, et al. Modification of Salmonella typhimurium motility by the probiotic yeast strain Saccharomyces boulardii. PLoS One 2012;7(3):e33796. PMid:22442723

Hatoum R, Labrie S, Fliss I. Antimicrobial and probiotic properties of yeasts: From fundamental to novel applications. Front Microbiol 2012;3:421. PMid:23267352

Ang LY, Too HK, Tan EL, Chow TK, Shek PC, Tham E, et al. Antiviral activity of Lactobacillus reuteri protectis against coxsackievirus a and enterovirus 71 infection in human skeletal muscle and colon cell lines. Virol J 2016;13(1):111. PMid:27341804

Galán NN, Rubiano JC, Reyes FA, Duarte KP, Cárdenas SP, Fernandez MF. In vitro antiviral activity of Lactobacillus casei and Bifidobacterium adolescentis against rotavirus infection monitored by NSP 4 protein production. J Appl Microbiol 2016;120(4):1041-51. PMid:26801008

Starosila D, Rybalko S, Varbanetz L, Ivanskaya N, Sorokulova I. Anti-influenza activity of a Bacillus subtilis probiotic strain. Antimicrob Agents Chemother 2017;61(7):e00539-17. PMid:28416546

Eguchi K, Fujitani N, Nakagawa H, Miyazaki T. Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055. Sci Rep 2019;9(1):4812. PMid:30886158

Gorbalenya AE, Baker SC, Baric RS, Groot RJ De, Gulyaeva AA, Haagmans BL, et al. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5(4):536-44.

Li F. Structure, function, and evolution of coronavirus spike proteins. Annu Rev Virol 2016;3(1):237-61. PMid:27578435

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382(8):727-33. PMid:31978945

Magrone T, Magrone M, Jirillo E. Focus on receptors for coronaviruses with special reference to angiotensin-converting enzyme 2 as a potential drug target a perspective. Endocr Metab Immune Disord Drug Targets 2020;20(6):807-11. PMid:32338224

Al Kassaa I, Hober D, Hamze M, Chihib NE, Drider D. Antiviral potential of lactic acid bacteria and their bacteriocins. Probiotics Antimicrob Proteins 2014;6(3-4):177-85. PMid:24880436

Prabhurajeshwar C, Chandrakanth K. Evaluation of antimicrobial properties and their substances against pathogenic bacteria in-vitro by probiotic lactobacilli strains isolated from commercial yoghurt. Clin Nutr Exp 2019;23:97-115.

Lin TH, Pan TM. Characterization of an antimicrobial substance produced by Lactobacillus plantarum NTU 102. J Microbiol Immunol Infect 2019;52(3):409-17. PMid:28863970

Abbasiliasi S, Tan JS, Ibrahim TA, Bashokouh F, Ramakrishnan NR, Mustafa S, et al. Fermentation factors influencing the production of bacteriocins by lactic acid bacteria: A review. RSC Adv 2017;7(47):29395-420.

Šušković J, Kos B, Beganović J, Pavunc AL, Habjanič K, Matoć S. Antimicrobial activity the most important property of probiotic and starter lactic acid bacteria. Food Technol Biotechnol 2010;48(3):296-307.

El-khawas K, Hassaan H. Control of food poisoning bacteria during manufacturing of acid cheese using some organic acids. Assiut Vet Med J 2015;145:40-6.

Lorca GL, de Valdez GF. In: Ljungh Å, Wadström T, editors. Lactobacillus Molecular Biology: From Genomics to Probiotics. Norfolk, United Kingdom: Caister Academic Press; 2009. p. 115-37.

Martin LS, McDougal JS, Loskoski SL. Disinfection and inactivation of the human T lymphotropic virus Type III/lymphadenopathy-associated virus. J Infect Dis 1985;152(2):400-3. PMid:2993438

Tuyama AC, Cheshenko N, Carlucci MJ, Li J, Goldberg CL, Waller DP, et al. ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: Optimal candidate for microbicide combinations. J Infect Dis 2006;194(6):795-803. PMid:16941346

Digaitiene A, Hansen ÅS, Juodeikiene G, Eidukonyte D, Josephsen J. Lactic acid bacteria isolated from rye sourdoughs produce bacteriocin-like inhibitory substances active against Bacillus subtilis and fungi. J Appl Microbiol 2012;112(4):732-42. PMid:22313683

Ge J, Sun Y, Xin X, Wang Y, Ping W. Purification and partial characterization of a novel bacteriocin synthesized by Lactobacillus paracasei HD1-7 isolated from Chinese sauerkraut juice. Sci Rep 2016;6(1):19366. PMid:26763314

Yang SC, Lin CH, Sung CT, Fang JY. Antibacterial activities of bacteriocins: Application in foods and pharmaceuticals. Front Microbiol 2014;5:241.] PMid:24904554

Yusuf MA. Lactic acid bacteria bacteriocin producer: A mini review. IOSR J Pharm 2013;3(4):44-50.

Arena MP, Silvain A, Normanno G, Grieco F, Drider D, Spano G, et al. Use of Lactobacillus plantarum strains as a bio-control strategy against food-borne pathogenic microorganisms. Front Microbiol 2016;7:464. PMid:27148172

Caramia G, Silvi S. Probiotics: From the ancient wisdom to the actual therapeutical and nutraceutical perspective. In: Probiotic Bacteria and Enteric Infections. Dordrecht: Springer Netherlands; 2011. p. 3-37.

Wachsman MB, Castilla V, De Ruiz Holgado AP, De Torres RA, Sesma F, Coto CE. Enterocin CRL35 inhibits late stages of HSV-1 and HSV-2 replication in vitro. Antiviral Res 2003;58(1):17-24. PMid:12719003

Arena MP, Elmastour F, Sane F, Drider D, Fiocco D, Spano G, et al. Inhibition of coxsackievirus B4 by Lactobacillus plantarum. Microbiol Res 2018;210:59-64. PMid:29625659

Serkedjieva J, Danova S, Ivanova I. Antiinfluenza virus activity of a bacteriocin produced by Lactobacillus delbrueckii. Appl Biochem Biotechnol 2000;88(1-3):285-98.

Torres NI, Noll KS, Xu S, Li J, Huang Q, Sinko PJ, et al. Safety, formulation and in vitro antiviral activity of the antimicrobial peptide subtilosin against herpes simplex virus Type 1. Probiotics Antimicrob Proteins 2013;5(1):26-35. PMid:23637711

Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010;4(8):118-26. PMid:22228951

Martin H, Maris P. Synergism between hydrogen peroxide and seventeen acids against six bacterial strains. J Appl Microbiol 2012;113(3):578-90. PMid:22716768

Baez A, Shiloach J. Effect of elevated oxygen concentration on bacteria, yeasts, and cells propagated for production of biological compounds. Microb Cell Fact 2014;13(1):181. PMid:25547171

Hertzberger R, Arents J, Dekker HL, Pridmore RD, Gysler C, Kleerebezem M, et al. H2O2 Production in species of the Lactobacillus acidophilus group: A central role for a novel NADH-dependent flavin reductase. Appl Environ Microbiol 2014;80(7):2229-39.

Serata M, Kiwaki M, Iino T. Functional analysis of a novel hydrogen peroxide resistance gene in Lactobacillus casei strain Shirota. Microbiology 2016;162(11):1885-94. PMid:27692041

Nita M, Grzybowski A. The role of the reactive oxygen species and oxidative stress in the pathomechanism of the agerelated ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev 2016;2016:3164734. PMid:26881021

Singh AK, Hertzberger RY, Knaus UG. Hydrogen peroxide production by lactobacilli promotes epithelial restitution during colitis. Redox Biol 2018;16:11-20. PMid:29471162

Newcomb WW, Brown JC. Internal catalase protects herpes simplex virus from inactivation by hydrogen peroxide. J Virol 2012;86(21):11931-4. PMid:22915822

Patel U, Gingerich A, Widman L, Sarr D, Tripp RA, Rada B. Susceptibility of influenza viruses to hypothiocyanite and hypoiodite produced by lactoperoxidase in a cell-free system. PLoS One 2018;13(7):e0199167. PMid:30044776

Conti C, Malacrino C, Mastromarino P. Inhibition of herpes simplex virus Type 2 by vaginal lactobacilli. J Physiol Pharmacol 2009;60 Suppl 6:19-26. PMid:20224147

Richards MR, Lowary TL. Chemistry and biology of galactofuranose-containing polysaccharides. Chembiochem 2009;10(12):1920-38. PMid:19591187

Ye S, Liu F, Wang J, Wang H, Zhang M. Antioxidant activities of an exopolysaccharide isolated and purified from marine Pseudomonas PF-6. Carbohydr Polym 2012;87(1):764-770.

Yang Y, Song H, Wang L, Dong W, Yang Z, Yuan P, et al. Antiviral effects of a probiotic metabolic mroducts against transmissible gastroenteritis coronavirus. J Probiotics Health 2017;5(3):184.

Callahan LN, Phelan M, Mallinson M, Norcross MA. Dextran sulfate blocks antibody binding to the principal neutralizing domain of human immunodeficiency virus Type 1 without interfering with gp120-CD4 interactions. J Virol 1991;65(3):1543-50. PMid:1995952

Wang Z, Chai W, Burwinkel M, Twardziok S, Wrede P, Palissa C, et al. Inhibitory influence of Enterococcus faecium on the propagation of swine influenza a virus in vitro. PLoS One 2013;8(1):e53043. PMid:23308134

Botić T, Danø T, Weingartl H, Cencič A. A novel eukaryotic cell culture model to study antiviral activity of potential probiotic bacteria. Int J Food Microbiol 2007;115(2):227-34. PMid:17261339

Mousavi E, Makvandi M, Teimoori A, Ataei A, Ghafari S, Samarbaf-Zadeh A. Antiviral effects of Lactobacillus crispatus against HSV-2 in mammalian cell lines. J Chinese Med Assoc 2018;81(3):262-7. PMid:29037754

Al Kassaa I, Hober D, Hamze M, Caloone D, Dewilde A, Chihib N, et al. Vaginal Lactobacillus gasseri CMUL57 can inhibit herpes simplex Type 2 but not coxsackievirus B4E2. Arch Microbiol 2015;197(5):657-64. PMid:25752765

Kawashima T, Hayashi K, Kosaka A, Kawashima M, Igarashi T, Tsutsui H, et al. Lactobacillus plantarum strain YU from fermented foods activates Th1 and protective immune responses. Int Immunopharmacol 2011;11(12):2017-24. PMid:21893216

Gagnon M, Zihler A, Chassard C, Lacroix C. Ecology of probiotics and enteric protection. In: Probiotic Bacteria and Enteric Infections. Dordrecht: Springer Netherlands; 2011. p. 65-85.

Hemaiswarya S, Raja R, Ravikumar R, Carvalho IS. Mechanism of action of probiotics. Braz Arch Biol Technol 2013;56(1):113-9.

Izumo T, Maekawa T, Ida M, Noguchi A, Kitagawa Y, Shibata H, et al. Effect of intranasal administration of Lactobacillus pentosus S-PT84 on influenza virus infection in mice. Int Immunopharmacol 2010;10(9):1101-6. PMid:20601181

Tomosada Y, Chiba E, Zelaya H, Takahashi T, Tsukida K, Kitazawa H, et al. Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection. BMC Immunol 2013;14(1):40. PMid:23947615

Yeo JM, Lee HJ, Kim JW, Lee JB, Park SY, Choi IS, et al. Lactobacillus fermentum CJL-112 protects mice against influenza virus infection by activating T-helper 1 and eliciting a protective immune response. Int Immunopharmacol 2014;18(1):50-4. PMid:24201084

Youn HN, Lee DH, Lee YN, Park JK, Yuk SS, Yang SY, et al. Intranasal administration of live Lactobacillus species facilitates protection against influenza virus infection in mice. Antiviral Res 2012;93(1):138-43. PMid:22120759

Iwabuchi N, Xiao JZ, Yaeshima T, Iwatsuki K. Oral administration of Bifidobacterium longum ameliorates influenza virus infection in mice. Biol Pharm Bull 2011;34(8):1352-5. PMid:21804232

Crawford SE, Ramani S, Tate JE, Parashar UD, Svensson L, Hagbom M, et al. Rotavirus infection. Nat Rev Dis Prim 2017;3(1):17083. PMid:29119972

Guarino A, Dupont C, Gorelov AV, Gottrand F, Lee JK, Lin Z, et al. The management of acute diarrhea in children in developed and developing areas: From evidence base to clinical practice. Expert Opin Pharmacother 2012;13(1):17-26. PMid:22106840

Patel MM, Haber P, Baggs J, Zuber P, Bines JE, Parashar UD. Intussusception and rotavirus vaccination: A review of the available evidence. Expert Rev Vaccines 2009;8(11):1555-64. PMid:19863248

Yang Y, Pei J, Qin Z, Wei L. Efficacy of probiotics to prevent and/or alleviate childhood rotavirus infections. J Funct Foods 2019;52:90-9.

Vlasova AN, Kandasamy S, Chattha KS, Rajashekara G, Saif LJ. Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species. Vet Immunol Immunopathol 2016;172:72-84. PMid:26809484

Erdoğan Ö, Tanyeri B, Torun E, Gönüllü E, Arslan H, Erenberk U, et al. The comparition of the efficacy of two different probiotics in rotavirus gastroenteritis in children. J Trop Med 2012;2012:787240. PMid:22778754

Park M, Kwon B, Ku S, Ji G. The efficacy of Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 probiotic treatment in infants with rotavirus infection. Nutrients 2017;9(8):887. PMid:28813007

Azagra-Boronat I, Massot-Cladera M, Knipping K, Garssen J, Ben Amor K, Knol J, et al. Strain-specific probiotic properties of bifidobacteria and lactobacilli for the prevention of diarrhea caused by rotavirus in a preclinical model. Nutrients 2020;12(2):498. PMid:32075234

Sindhu KN, Sowmyanarayanan TV, Paul A, Babji S, Ajjampur SS, Priyadarshini S, et al. Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: A randomized, double-blind, placebo-controlled trial. Clin Infect Dis 2014;58(8):1107-15. PMid:24501384

Fernandez-Duarte KP, Olaya-Galán NN, Salas-Cárdenas SP, Lopez-Rozo J, Gutierrez-Fernandez MF. Bifidobacterium adolescentis (DSM 20083) and Lactobacillus casei (Lafti L26-DSL): Probiotics able to block the in vitro adherence of rotavirus in MA104 cells. Probiotics Antimicrob Proteins 2018;10(1):56-63. PMid:28432676

Han YO, Jeong Y, You HJ, Ku S, Ji GE, Park MS. The antirotaviral activity of low molecular weight and non-proteinaceous substance from Bifidobacterium longum BORI cell extract. Microorganisms 2019;7(4):108. PMid:31018530

Lopman BA, Reacher MH, Vipond IB, Sarangi J, Brown DW. Clinical manifestation of norovirus gastroenteritis in health care settings. Clin Infect Dis 2004;39(3):318-24. PMid:15306997

Green KY. Norovirus infection in immunocompromised hosts. Clin Microbiol Infect 2014;20(8):717-23. PMid:25040790

Murata T, Katsushima N, Mizuta K, Muraki Y, Hongo S, Matsuzaki Y. Prolonged norovirus shedding in infants. Pediatr Infect Dis J 2007;26(1):46-9. PMid:17195705

Kocher J, Yuan L. Norovirus vaccines and potential antinorovirus drugs: Recent advances and future perspectives. Future Virol 2015;10(7):899-913. PMid:26568768

Chen YL, Chang PJ, Huang CT. Small P particles formed by the Taiwan-native norovirus P domain overexpressed in Komagataella pastoris. Appl Microbiol Biotechnol 2018;102(22):9707-18. PMid:30187100

Miura T, Sano D, Suenaga A, Yoshimura T, Fuzawa M, Nakagomi T, et al. Histo-blood group antigen-like substances of human enteric bacteria as specific adsorbents for human noroviruses. J Virol 2013;87(17):9441-51. PMid:23804639

Lei S, Samuel H, Twitchell E, Bui T, Ramesh A, Wen K, et al. Enterobacter cloacae inhibits human norovirus infectivity in gnotobiotic pigs. Sci Rep 2016;6(1):25017. PMid:27113278

Rubio-del-Campo A, Coll-Marqués JM, Yebra MJ, Buesa J, Pérez-Martínez G, Monedero V, et al. Noroviral P-particles as an in vitro model to assess the interactions of noroviruses with probiotics. PLoS One 2014;9(2):e89586. PMid:24586892

Hao Q, Dong BR, Wu T. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev 2015;9:CD006895. PMid:21901706

Fonkwo PN. Pricing infectious disease. EMBO Rep 2008;9(Suppl 1):S13-7. PMid:18578017

Nichols WG, Campbell AJ, Boeckh M. Respiratory viruses other than influenza virus: Impact and therapeutic advances. Clin Microbiol Rev 2008;21(2):274-90. PMid:18400797

Robinson CM, Seto D, Jones MS, Dyer DW, Chodosh J. Molecular evolution of human species D adenoviruses. Infect Genet Evol 2011;11(6):1208-17. PMid:21570490

Langley GF, Anderson LJ. Epidemiology and prevention of respiratory syncytial virus infections among infants and young children. Pediatr Infect Dis J 2011;30(6):510-7. PMid:21487331

Tapparel C, Siegrist F, Petty TJ, Kaiser L. Picornavirus and enterovirus diversity with associated human diseases. Infect Genet Evol 2013;14:282-93. PMid:23201849

Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009;360(6):588-98. PMid:19196675

Henderson J, Hilliard TN, Sherriff A, Stalker D, Al Shammari N, Thomas HM. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: A longitudinal birth cohort study. Pediatr Allergy Immunol 2005;16(5):386-92. PMid:16101930

Higgins D, Trujillo C, Keech C. Advances in RSV vaccine research and development a global agenda. Vaccine 2016;34(26):2870-5. PMid:27105562

Openshaw PJ, Chiu C, Culley FJ, Johansson C. Protective and harmful immunity to RSV infection. Annu Rev Immunol 2017;35(1):501-32. PMid:28226227

Iwane MK, Prill MM, Lu X, Miller EK, Edwards KM, Hall CB, et al. Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children. J Infect Dis 2011;204(11):1702-10. PMid:22013207

Esneau C, Bartlett N, Bochkov YA. Rhinovirus structure, replication, and classification. In: Rhinovirus Infections. Amsterdam, Netherlands: Elsevier; 2019. p. 1-23.

Luoto R, Ruuskanen O, Waris M, Kalliomäki M, Salminen S, Isolauri E. Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebocontrolled trial. J Allergy Clin Immunol 2014;133(2):405-13. PMid:24131826

Kumpu M, Kekkonen RA, Korpela R, Tynkkynen S, Järvenpää S, Kautiainen H, et al. Effect of live and inactivated Lactobacillus rhamnosus GG on experimentally induced rhinovirus colds: Randomised, double blind, placebo-controlled pilot trial. Benef Microbes 2015;6(5):631-9. PMid:26322544

Esposito S, Rigante D, Principi N. Do children’s upper respiratory tract infections benefit from probiotics? BMC Infect Dis 2014;14(1):194. PMid:24720809

Lehtoranta L, Pitkäranta A, Korpela R. Probiotics in respiratory virus infections. Eur J Clin Microbiol Infect Dis 2014;33(8):1289-302. PMid:24638909

Howley PM, Knipe DM. Fields Virology: Emerging Viruses. Philadelphia, Pennsylvania, PA: Lippincott Williams and Wilkins; 2020.

Koutsakos M, Nguyen TH, Barclay WS, Kedzierska K. Knowns and unknowns of influenza B viruses. Future Microbiol 2016;11(1):119-35. PMid:26684590

Hayden FG. Pandemic influenza. Pediatr Infect Dis J 2004;23(11 Suppl):S262-9. PMid:15577582

Verity EE, Camuglia S, Agius CT, Ong C, Shaw R, Barr I, et al. Rapid generation of pandemic influenza virus vaccine candidate strains using synthetic DNA. Influenza Other Respi Viruses 2012;6(2):101-9. PMid:21771285

Makino S, Sato A, Goto A, Nakamura M, Ogawa M, Chiba Y, et al. Enhanced natural killer cell activation by exopolysaccharides derived from yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1. J Dairy Sci 2016;99(2):915-23. PMid:26686726

Nagai T, Makino S, Ikegami S, Itoh H, Yamada H. Effects of oral administration of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 and its exopolysaccharides against influenza virus infection in mice. Int Immunopharmacol 2011;11(12):2246-50. PMid:21986509

Goto H, Sagitani A, Ashida N, Kato S, Hirota T, Shinoda T, et al. Anti-influenza virus effects of both live and non-live Lactobacillus acidophilus L-92 accompanied by the activation of innate immunity. Br J Nutr 2013;110(10):1810-8. PMid:23594927

Mahooti M, Abdolalipour E, Salehzadeh A, Mohebbi SR, Gorji A, Ghaemi A. Immunomodulatory and prophylactic effects of Bifidobacterium bifidum probiotic strain on influenza infection in mice. World J Microbiol Biotechnol 2019;35(6):91. PMid:31161259

Robinson CM, Singh G, Lee JY, Dehghan S, Rajaiya J, Liu EB, et al. Molecular evolution of human adenoviruses. Sci Rep 2013;3(1):1812 PMid:23657240

Waye MM, Sing CW. Anti-viral drugs for human adenoviruses. Pharmaceuticals 2010;3(10):3343-54.

Ryan PM, Ross RP, Fitzgerald GF, Caplice NM, Stanton C. Sugar-coated: Exopolysaccharide producing lactic acid bacteria for food and human health applications. Food Funct 2015;6(3):679-93. PMid:25580594

BiliavskaL, Pankivska Y, Povnitsa O, Zagorodnya S. Antiviral activity of exopolysaccharides produced by lactic acid bacteria of the genera Pediococcus, Leuconostoc and Lactobacillus against human adenovirus Type 5. Medicina (B Aires) 2019;55(9):519. PMid:31443536

Cheung KS, Hung IF, Chan PP, Lung KC, Tso E, Liu R, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: Systematic review and meta-analysis. Gastroenterology 2020;159(1):81-95. PMid:32251668

Arshad MS, Khan U, Sadiq A, Khalid W, Hussain M, Yasmeen A, et al. Coronavirus disease (COVID-19) and immunity booster green foods: A mini review. Food Sci Nutr 2020;8(8):3971-6. PMid:32837716

de Araújo Morais AH, de Souza Aquino J, da Silva-Maia JK, de Lima Vale SH, Maciel BL, Passos TS. Nutritional status, diet and viral respiratory infections: Perspectives for severe acute respiratory syndrome coronavirus 2. Br J Nutr 2020;1:1-12. PMid:32843118

Chai W, Burwinkel M, Wang Z, Palissa C, Esch B, Twardziok S, et al. Antiviral effects of a probiotic Enterococcus faecium strain against transmissible gastroenteritis coronavirus. Arch Virol 2013;158(4):799-807. PMid:23188495

Angurana SK, Bansal A. Probiotics and COVID-19: Think about the link. Br J Nutr 2020;1:1-26. PMid:32921328

Aanouz I, Belhassan A, El-Khatabi K, Lakhlifi T, El-ldrissi M, Bouachrine M. Moroccan medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations. J Biomol Struct Dyn 2020;1:1-9. PMid:32306860

Anwar F, Altayb HN, Al-Abbasi FA, Al-Malki AL, Kamal MA, Kumar V. Antiviral effects of probiotic metabolites on COVID-19. J Biomol Struct Dyn 2020;1:1-10. PMid:32475223

Baud D, Agri VD, Gibson GR, Reid G, Giannoni E. Using probiotics to flatten the curve of coronavirus disease COVID-2019 pandemic. Front Public Health 2020;8:186. PMid:32574290

Infusino F, Marazzato M, Mancone M, Fedele F, Mastroianni CM, Severino P, et al. Diet supplementation, probiotics, and nutraceuticals in SARS-CoV-2 infection: A scoping review. Nutrients 2020;12(6):1718. PMid:32521760

Inchingolo F, Dipalma G, Cirulli N, Cantore S, Saini RS, Altini V, et al. Microbiological results of improvement in periodontal condition by administration of oral probiotics. J Biol Regul Homeost Agents 2018;32(5):1323-8. PMid:30334433

Dhar D, Mohanty A. Gut microbiota and Covid-19- possible link and implications. Virus Res 2020;285:198018. PMid:32430279

Henrot C, Kuksin M. The intestinal virobiota, a new component in the interactions between the microbiota and the immune system. Med Sci (Paris) 2019;35(6-7):578-580. doi: 10.1051/medsci/2019113.

Santacroce L. Letter in response to the article “enhancing immunity in viral infections, with special emphasis on COVID-19: A review” (Jayawardena et al.). Diabetes Metab Syndr Clin Res Rev 2020;14(5):927. PMid:32585601

Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr 2020;39(4):255-9.

Ventoulis I, Sarmourli T, Amoiridou P, Mantzana P, Exindari M, Gioula G, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi 2020;6(3):98. PMid:32630111




How to Cite

Salman JA-S, Mahmood NN, Abdulsattar BO, Abid HA. The Effectiveness of Probiotics against Viral Infections: A Rapid Review with Focus on SARS-CoV-2 Infection. Open Access Maced J Med Sci [Internet]. 2020 Nov. 9 [cited 2023 May 29];8(T1):496-508. Available from: