Probiotics May Improve Serum Folate Availability in Pregnant Women: A Pilot Study

Andrea  Ballini; Luca  Signorini; Alessio Danilo   Inchingolo; Rajiv  Saini; Antonio  Gnoni; Salvatore  Scacco; Stefania   Cantore; Gianna  Dipalma; Francesco   Inchingolo; Luigi Santacroce

doi:10.3889/oamjms.2020.5494

Authors

Andrea Ballini Department of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario “Ernesto Quagliariello”, University of Bari “Aldo Moro”, Bari, Italy; Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy
Luca Signorini Departmental Faculty of Medicine and Surgery, Unicamillus University, Rome, Italy
Alessio Danilo Inchingolo Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Bari, Italy
Rajiv Saini Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Bari, Italy; Department of Ionian, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy
Antonio Gnoni Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Salvatore Scacco Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Stefania Cantore Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Bari, Italy
Gianna Dipalma Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Bari, Italy
Francesco Inchingolo Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Bari, Italy
Luigi Santacroce Department of Ionian, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy; Department of Clinical Disciplines, School of Technical Medical Sciences, “A. Xhuvani” University, Elbasan, Albania http://orcid.org/0000-0001-5671-8124

DOI:

https://doi.org/10.3889/oamjms.2020.5494

Keywords:

Probiotics, Folate, Folic acid, Glycemia, Weight, Pregnancy

Abstract

BACKGROUND: Probiotics are living microorganisms that confer a health benefit when administered in adequate amounts. There is evidence in the current literature about the importance of probiotic use in pregnancy. The early supplementation of probiotics in the perinatal and postnatal periods seems to have a positive impact on the overall mother’s health and future health of infants.

AIM: Our pilot study aimed to test the ability of specific probiotics strains in combination with the kiwi-unique enzyme actinidin to improve the availability of folic acid in 20 pregnant women.

METHODS: We investigate 20 pregnant women in early (4–10 weeks) (6 patients), intermedium (11–20 weeks) (6 patients), and late (21–30 weeks) (8 patients) pregnancy.

RESULTS: Our findings show that the tested formula promotes increased concentration of serum folate in women’s blood and contributes to the control of blood sugar and body weight, regardless of the gestational period (early, intermediate or late).

CONCLUSIONS: Our data support the main results reported in the scientific literature about the importance of probiotics intake in pregnancy.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

Author Biography

Luigi Santacroce, Department of Ionian, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy; Department of Clinical Disciplines, School of Technical Medical Sciences, “A. Xhuvani” University, Elbasan, Albania

References

Xu W, Judge MP, Maas K, Hussain N, McGrath JM, Henderson WA, et al. Systematic review of the effect of enteral feeding on gut microbiota in preterm infants. J Obstet Gynecol Neonatal Nurs. 2018;47(3):451-63. https://doi.org/10.1016/j.jogn.2017.08.009 PMid:29040820

Inchingolo F, Santacroce L, Cantore S, Ballini A, Del Prete R, Topi S, et al. Probiotics and EpiCor® in human health. J Biol Regul Homeost Agents. 2019;33:1973-9. PMid:31858774

Santacroce L, Sardaro N, Topi S, Pettini F, Bottalico L, Cantore S, et al. The pivotal role of oral microbiota in health and disease. J Biol Regul Homeost Agents. 2020;34(2):733-7. PMid:32492992

Samuel TM, Sakwinska O, Makinen K, Burdge GC, Godfrey KM, Silva-Zolezzi I. Preterm birth: A narrative review of the current evidence on nutritional and bioactive solutions for risk reduction. Nutrients. 2019;11(8):1811. https://doi.org/10.3390/nu11081811 PMid:31390765

Santacroce L, Bottalico L, Topi S, Castellaneta F, Charitos IA. The “Scourge of the Renaissance”. A Short Review About Treponema pallidum infection. Endocr Metab Immune Disord Drug Targets. 2020;20(3):335-343. https://doi.org/10.2174/1871530319666191009144217. PMid: 31625831.

Santacroce L, Charitos IA, Bottalico L. A successful history: Probiotics and their potential as antimicrobials. Expert Rev Anti Infect Ther. 2019;17(8):635-45. https://doi.org/10.1080/14787210.2019.1645597 PMid:31318576

Laitinen K, Poussa T, Isolauri E. Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: A randomised controlled trial. Br J Nutr. 2009;101(11):1679-87. https://doi.org/10.1017/s0007114508111461 PMid:19017418

Tatullo M, Marrelli M, Scacco S, Lorusso M, Doria S, Sabatini R, et al. Relationship between oxidative stress and burning mouth syndrome in female patients: A scientific hypothesis. Eur Rev Med Pharmacol Sci. 2012;16(9):1218-21. PMid:23047505

Marrelli M, Maletta C, Inchingolo F, Alfano M, Tatullo M. Three-point bending tests of zirconia core/veneer ceramics for dental restorations. Int J Dent. 2013;2013:831976. https://doi.org/10.1155/2013/831976 PMid:23533415

Milman N, Paszkowski T, Cetin I, Castelo-Branco C. Supplementation during pregnancy: Beliefs and science. Gynecol Endocrinol. 2016;32(7):509-16. https://doi.org/10.3109/09513590.2016.1149161 PMid:26956254

Gluckman PD, Hanson MA, Mitchell MD. Developmental origins of health and disease: Reducing the burden of chronic disease in the next generation. Genome Med. 2010;2(2):14. https://doi.org/10.1186/gm135 PMid:20236494

Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2017;4(4):CD004905. https://doi.org/10.1002/14651858.cd004905.pub5 PMid:28407219

Rautava S, Kalliomäki M, Isolauri E. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J Allergy Clin Immunol. 2002;109(1):119-21. https://doi.org/10.1067/mai.2002.120273 PMid:11799376

Kalliomäki M, Salminen S, Poussa T, Isolauri E. Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trial. J Allergy Clin Immunol. 2007;119(4):1019-21. https://doi.org/10.1016/j.jaci.2006.12.608 PMid:17289135

Man A, Ciurea CN, Pasaroiu D, Savin AI, Toma F, Sular F, Santacroce L, Mare A. New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study. Mem Inst Oswaldo Cruz. 2017 Sep;112(9):587-592. https://doi.org/10.1590/0074-02760170098. PMid: 28902283

Paduano F, Marrelli M, Alom N, Amer M, White LJ, Shakesheff KM, et al. Decellularized bone extracellular matrix and human dental pulp stem cells as a construct for bone regeneration. J Biomater Sci Polym Ed. 2017;28(8):730-48. https://doi.org/10.1080/09205063.2017.1301770 PMid:28285576

Mantaring J, Benyacoub J, Destura R, Pecquet S, Vidal K, Volger S, et al. Effect of maternal supplement beverage with and without probiotics during pregnancy and lactation on maternal and infant health: A randomized controlled trial in the Philippines. BMC Pregnancy Childbirth. 2018;18(1):193. https://doi.org/10.1186/s12884-018-1828-8 PMid:29855271

Lee CS, Kim SH. Anti-inflammatory and anti-osteoporotic potential of Lactobacillus plantarum A41 and L. fermentum SRK414 as probiotics. Probiotics Antimicrob Proteins. 2020;12(2):623-34. https://doi.org/10.1007/s12602-019-09577-y PMid:31372901

Ballini A, Cantore S, Scacco S, Coletti D, Tatullo M. Mesenchymal stem cells as promoters, enhancers, and playmakers of the translational regenerative medicine. Stem Cells Int. 2018;2018:6927401. https://doi.org/10.1155/2018/6927401 PMid:30510586

Kerativitayanan P, Tatullo M, Khariton M, Joshi P, Perniconi B, Gaharwar AK. Nanoengineered osteoinductive and elastomeric scaffolds for bone tissue engineering. ACS Biomater Sci Eng. 2017;3:590-600. https://doi.org/10.1021/acsbiomaterials.7b00029

Van Sande H, Jacquemyn Y, Karepouan N, Ajaji M. Vitamin B12 in pregnancy: Maternal and fetal/neonatal effects. A review. Open J Obstetr Gynecol. 2013;3(7):599-602. https://doi.org/10.4236/ojog.2013.37107

Bardosono S, Wibowo N, Sutanto LB, Irwinda R, Cannan R, Rowan A, et al. Plasma folate, Vitamin B6 and B12 in their relationship to the presence of probiotic strain Bifidobacterium animalis subsp. Lactis HNO19 (DR10TM) among Indonesian pregnant women in their third semester. World Nutr J. 2018;2(2):56. https://doi.org/10.25220/wnj.v02.i2.0009

Kijmanawat A, Panburana P, Reutrakul S, Tangshewinsirikul C. Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: A double-blind randomized controlled trial. J Diabetes Investig. 2019;10(1):163-70. https://doi.org/10.1111/jdi.12863 PMid:29781243

Barry M, Pearce H, Cross L, Tatullo M, Gaharwar AK. Advances in nanotechnology for the treatment of osteoporosis. Curr Osteoporos Rep. 2016;14(3):87-94. https://doi.org/10.1007/s11914-016-0306-3 PMid:27048473

Ballini A, Santacroce L, Cantore S, Bottalico L, Dipalma G, Topi S, et al. Probiotics efficacy on oxidative stress values in inflammatory bowel disease: A randomized double-blinded placebo-controlled pilot study. Endocr Metab Immune Disord Drug Targets. 2019;19(3):373-81. https://doi.org/10.2174/1871530319666181221150352 PMid:30574857

Campanella V, Syed J, Santacroce L, Saini R, Ballini A, Inchingolo F. Oral probiotics influence oral and respiratory tract infections in pediatric population: A randomized double-blinded placebo-controlled pilot study. Eur Rev Med Pharmacol Sci. 2018;22(22):8034-41. PMid:30536353

Ballini A, Santacroce L, Cantore S, Bottalico L, Dipalma G, Vito D, et al. Probiotics improve urogenital health in women. Open Access Maced J Med Sci. 2018;6(10):1845-50. https://doi.org/10.3889/oamjms.2018.406 PMid:30455760

Ballini A, Gnoni A, De Vito D, Dipalma G, Cantore S, Isacco CG, et al. Effect of probiotics on the occurrence of nutrition absorption capacities in healthy children: A randomized double-blinded placebo-controlled pilot study. Eur Rev Med Pharmacol Sci. 2019;23(19):8645-57. https://doi.org/10.2174/1871530319666181221150352 PMid:31646599

Cicinelli E, Ballini A, Marinaccio M, Poliseno A, Coscia MF, Monno R, et al. Microbiological findings in endometrial specimen: Our experience. Arch Gynecol Obstet. 2012;285(5):1325-9. https://doi.org/10.1007/s00404-011-2138-9 PMID:22113463

Prete RD, Ronga L, Addati G, Magrone R, Abbasciano A, Carlo DD, et al. A retrospective study about the impact of switching from nested PCR to multiplex real-time PCR on the distribution of the human papillomavirus (HPV) genotypes. Medicina (Kaunas). 2019;55(8):418. https://doi.org/10.3390/medicina55080418 PMid:31366156

Coscia MF, Monno R, Ballini A, Mirgaldi R, Dipalma G, Pettini F, et al. Human papilloma virus (HPV) genotypes prevalence in a region of South Italy (Apulia). Ann Ist Super Sanita. 2015;51(3):248-51. PMid:26428051

Inchingolo F, Dipalma G, Cirulli N, Cantore S, Saini RS, Altini V, et al. Microbiological results of improvement in periodontal condition by administration of oral probiotics. J Biol Regul Homeost Agents. 2018;32(5):1323-8. PMid:30334433

Cantore S, Ballini A, Mori G, Dibello V, Marrelli M, Mirgaldi R, et al. Anti-plaque and antimicrobial efficiency of different oral rinses in a 3-day plaque accumulation model. J Biol Regul Homeost Agents. 2016;30(4):1173-8. PMid:28078871

Cantore S, Mirgaldi R, Ballini A, Coscia MF, Scacco S, Papa F, et al. Cytokine gene polymorphisms associate with microbiogical agents in periodontal disease: our experience. Int J Med Sci. 2014;11(7):674-9. https://doi.org/10.7150/ijms.6962 PMid:24843315