The Role of High-sensitivity C-reactive Protein Serum in Assessing Troponin T in Acute Myocardial Infarction

Taufik Indrajaya; Mgs Irsan Saleh; Miliyandra Miliyandra

doi:10.3889/oamjms.2020.5495

Authors

Taufik Indrajaya Department of Internal Medicine, Cardiovascular Division, Faculty of Medicine, Universitas Sriwijaya, Indonesia
Mgs Irsan Saleh Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Indonesia
Miliyandra Miliyandra Department of Internal Medicine, Cardiovascular Division, Faculty of Medicine, Universitas Sriwijaya, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.5495

Keywords:

troponin-t, acute coronary syndrome, routine diagnostic tests, sensitivity and specificity, myocardial infarction.

Abstract

BACKGROUND: The incidence of acute myocardial infarction (AMI) is increasing worldwide. Inflammation plays an essential role in the initiation and progression of atherosclerosis and the pathogenesis of acute cardiovascular events. C-reactive protein (CRP) has been shown to have prognostic value in patients with acute coronary syndrome, but the most promising use of CRP has been used for primary use.

AIM: This study was aimed to explore the sensitivity of high-sensitivity CRP (hs-CRP) in assessing troponin T in AMI.

METHODS: The study design was an observational study to assess the sensitivity and specificity of hsCRP against troponin T in patients with AMI with ST-elevation and without ST-elevation. This research was conducted in Palembang, Indonesia. The study subjects were 56 patients with an acute myocardial infusion that met the inclusion and exclusion criteria.

RESULTS: The sensitivity of hs-CRP to troponin-T is 93.7%. The specificity of hs-CRP to troponin T was 37.5%. The positive suspected value is 0.9, the estimated negative value is 0.5, the positive likelihood ratio is 1.49, and the negative likelihood ratio is 0.16.

CONCLUSION: hs-CRP is quite sensitive in assessing troponin-T but not specific enough in assessing troponin-T activity.

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