The Reactive Carbonyl Derivatives of Proteins, Methylglyoxal, and Malondialdehyde in Blood of Women with Breast Cancer

Authors

  • Sabina Zhumakayeva Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan https://orcid.org/0000-0001-7072-554X
  • Larissa Muravlyova Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
  • Valentina Sirota Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
  • Vilen Molotov-Luchansky Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
  • Ryszhan Bakirova Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
  • Nailya Kabildina Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
  • Xeniya Mkhitaryan Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan https://orcid.org/0000-0002-7142-7656
  • Ainura Zhumakayeva Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan

DOI:

https://doi.org/10.3889/oamjms.2021.5564

Keywords:

Breast cancer, Oxidative stress, Malondialdehyde

Abstract

BACKGROUND: Every year 1.5 million women in the world are diagnosed with breast cancer (BC). In 2018, more than 260,000 new cases of cancer and more than 40,000 deaths due to this disease were detected. At the same time, in Kazakhstan, an intensive indicator of the incidences of BC in 2018 amounted to 25.3% per population of 100 thousand people (2017–24.5%) with a growth rate of 3.1%, which in absolute numbers are 4,648 new cases per year. In terms of mortality, BC ranks third after lung and stomach cancer (6.8%).

AIM: This necessitates a detailed study of the molecular mechanisms that underlie the development and progression of BC. One of the mechanisms of carcinogenesis is oxidative stress (OS). An increase in malondialdehyde (MDA) levels was detected in the early stages of cancer. It was suggested that MDA, due to its high cytotoxicity, acts as a promoter of the tumor and cocarcinogen agent.

METHODS: Therefore, violation of the parameters of OS in BC is in no doubt. However, according to the literature data analysis, these results are ambiguous and contradictory. There are no studies on a comprehensive assessment of the oxidative destruction of lipids, proteins, and nucleic acids in BC.

CONCLUSION: The nature and direction of changes in various components of OS in patients with BC have not been adequately studied, which is necessary for a correct assessment of the involvement of OS in the mechanism of the pathological process and determination of a sensitive marker of the risk of BC or its progression.

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References

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7-30. PMid:29313949 DOI: https://doi.org/10.3322/caac.21442

Indicators of the Oncological Service of the Republic of Kazakhstan for 2018 (Statistical and Analytical Materials), Almaty; 2019. p. 210.

Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol. 2014;24(10):R453-62. https://doi.org/10.1016/j.cub.2014.03.034 PMid:24845678 DOI: https://doi.org/10.1016/j.cub.2014.03.034

Barrera G. Oxidative stress and lipid peroxidation products in cancer progression and therapy. ISRN Oncol. 2012;2012:137289. https://doi.org/10.5402/2012/137289 PMid:23119185 DOI: https://doi.org/10.5402/2012/137289

Jang HH. Regulation of protein degradation by proteasomes in cancer. J Cancer Prev. 2018;23(4):153-61. PMid:30671397 DOI: https://doi.org/10.15430/JCP.2018.23.4.153

Alnajjar KS, Sweasy JB. A new perspective on oxidation of DNA repair proteins and cancer. DNA Repair (Amst). 2019;76:60-9. https://doi.org/10.1016/j.dnarep.2019.02.006 PMid:30818170 DOI: https://doi.org/10.1016/j.dnarep.2019.02.006

Okrut IE, Kontorshchikova KN, Shakerova DA. Clinical and laboratory assessment of endothelial dysfunction and activity of free radical oxidation in breast cancer. Med Almanac. 2012;2(21):68-70.

Farias JW, Furtado FS, Guimarães SB, Filho AR, Vasconcelos PR. Oxidative stress parameters in women with breast cancer undergoing neoadjuvant chemotherapy and treated with nutraceutical doses of oral glutamine Acta Cir Bras. 2011;26 Suppl 1:82-7. https://doi.org/10.1590/s0102-86502011000700017 PMid:21971664 DOI: https://doi.org/10.1590/S0102-86502011000700017

Frenchman EM, Soldatkina NV, Orlovskaya LA, Dashkov AV. Some indicators of free radical processes and the antioxidant system of breast tumor tissue and its perifocal zone in various types of cancer. Tyumen Med J. 2010;3-4:92-4.

Rajneesh CP, Manimaran A, Sasikala KR, Adaikappan P. Lipid peroxidation and antioxidant status in patients with breast cancer. Singapore Med J. 2008;49(8):640-3. PMid:18756349

Rossner P, Terry MB, Gammon MD, Agrawal M, Zhang FF, Ferris JS, et al. Plasma protein carbonyl levels and breast cancer risk. J Cell Mol Med. 2007;11(5):1138-48. https://doi.org/10.1111/j.1582-4934.2007.00097.x PMid:17979889 DOI: https://doi.org/10.1111/j.1582-4934.2007.00097.x

Aryal BP, Rao A. Oxidative stress and selective protein carbonylation in human breast cancer tissue. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017. Washington, DC, Philadelphia, PA: AACR; 2017. https://doi.org/10.1158/1538-7445.am2017-5486 DOI: https://doi.org/10.1158/1538-7445.AM2017-5486

Mannello F, Tonti GA, Medda V. Protein oxidation in breast microenvironment: Nipple aspirate fluid collected from breast cancer women contains increased protein carbonyl concentration. Cell Oncol. 2009;31(5):383-92. https://doi.org/10.1155/2009/545896 PMid:19759418 DOI: https://doi.org/10.1155/2009/545896

Lee JD, Cai Q, Ou Shu X, Nechuta SJ. The role of biomarkers of oxidative stress in breast cancer risk and prognosis: A systematic review of the epidemiologic literature. J Womens Health (Larchmt). 2017;26(5):467-82. https://doi.org/10.1089/jwh.2016.5973 PMid:28151039 DOI: https://doi.org/10.1089/jwh.2016.5973

Rabbani N, Xue M, Thornalley PJ. Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics. Glycoconj J. 2016;33(4):513-25. https://doi.org/10.1007/s10719-016-9705-z PMid:27406712 DOI: https://doi.org/10.1007/s10719-016-9705-z

Roy A, Sarker S, Upadhyay P, Pal A, Adhikary A, Jana K, et al. Methylglyoxal at metronomic doses sensitizes breast cancer cells to doxorubicin and cisplatin causing synergistic induction of programmed cell death and inhibition of stemness. Biochem Pharmacol. 2018;156:322-39. https://doi.org/10.1016/j.bcp.2018.08.041 PMid:30170097 DOI: https://doi.org/10.1016/j.bcp.2018.08.041

Krishna KA, Pawan AR, Babu BN, Gorantla N. Anti-cancer strategies of methylglyoxal-a review. Int J Pharma Res Rev. 2015;4(7):38-42.

Nokin MJ, Durieux F, Bellier J, Peulen O, Uchida K, Spiegel DA, et al. Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death. Sci Rep. 2017;7(1):11722. https://doi.org/10.1038/s41598-017-12119-7 PMid:28916747 DOI: https://doi.org/10.1038/s41598-017-12119-7

Rabbani N, Xue M, Thornalley PJ. Methylglyoxal-induced dicarbonyl stress in aging and disease: First steps towards glyoxalase 1-based treatments. Clin Sci (Lond). 2016;130(19):1677-96. https://doi.org/10.1042/cs20160025 PMid:27555612 DOI: https://doi.org/10.1042/CS20160025

Rabbani N, Xue M, Weickert MO, Thornalley PJ. Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology-Involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy. Semin Cancer Biol. 2018;49:83-93. https://doi.org/10.1016/j.semcancer.2017.05.006 PMid:28506645 DOI: https://doi.org/10.1016/j.semcancer.2017.05.006

Singh A, Kukreti R, Saso L, Kukreti S. Oxidative stress: A key modulator in neurodegenerative diseases. Molecules. 2019;24(8):1583. https://doi.org/10.3390/molecules24081583 PMid:31013638 DOI: https://doi.org/10.3390/molecules24081583

Barrera G, Pizzimenti S, Daga M, Dianzani C, Arcaro A, Cetrangolo GP, et al. Lipid peroxidation-derived aldehydes, 4-hydroxynonenal and malondialdehyde in aging-related disorders. Antioxidants (Basel). 2018;7(8):102. https://doi.org/10.3390/antiox7080102 PMid:30061536 DOI: https://doi.org/10.3390/antiox7080102

Bellier J, Nokin MJ, Lardé E, Karoyan P, Peulen O, Castronovo V, et al. Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer. Diabetes Res Clin Pract. 2019;148:200-11. https://doi.org/10.1016/j.diabres.2019.01.002 PMid:30664892 DOI: https://doi.org/10.1016/j.diabres.2019.01.002

Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990;186:464-78. https://doi.org/10.1016/0076-6879(90)86141-h PMid:1978225 DOI: https://doi.org/10.1016/0076-6879(90)86141-H

Husna AH, Ramadhani EA, Eva DT, Yulita AF, Suhartono E. The role formation of methylglyoxal, carbonyl compound, hydrogen peroxide and advance oxidation protein product induced cadmium in ovarian rat. Int J Chem Eng Appl. 2014;5(4):319-23. https://doi.org/10.7763/ijcea.2014.v5.402 DOI: https://doi.org/10.7763/IJCEA.2014.V5.402

Goncharenko MS, Latinova AM. Method of Assessment of Peroxide Oxidation of Lipids, Lab Case No. 1; 1985.

Korobeinikova EN. Modification of the Determination of Lipid Peroxidation Products in Reaction with Thiobarbituric Acid Lab Case No. 7; 1989. p. 8-10.

Bratt D, Jethva KH, Patel S, Zaveri M. Role of oxidative stress in breast cancer. Pharm pharm Sci. 2016;5(11):366-79.

Nourazarian AR, Kangari P, Salmaninejad A. Roles of oxidative stress in the development and progression of breast cancer. Asian Pac J Cancer Prev. 2014;5(12):4745-51. https://doi.org/10.7314/apjcp.2014.15.12.4745 PMid:24998536 DOI: https://doi.org/10.7314/APJCP.2014.15.12.4745

Chakraborty S, Karmakar K, Chakravortty D. Cells producing their own nemesis: Understanding methylglyoxal metabolism. IUBMB Life. 2014;66(10):667-78. https://doi.org/10.1002/iub.1324 PMid:25380137 DOI: https://doi.org/10.1002/iub.1324

Nokin M, Bellier J, Durieux F, Peulen O, Rademaker G, Gabriel M, et al. Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer. Breast Cancer Res. 2019;21(1):1. https://doi.org/10.1186/s13058-018-1095-7 DOI: https://doi.org/10.1186/s13058-018-1095-7

Prestes AS, Dos Santos MM, Ecker A, Zanini D, Schetinger MR, Rosemberg DB, et al. Evaluation of methylglyoxal toxicity in human erythrocytes, leukocytes and platelets. Toxicol Mech Methods. 2017;27(4):307-17. https://doi.org/10.1080/15376516.2017.1285971 PMid:28110610 DOI: https://doi.org/10.1080/15376516.2017.1285971

Madian AG, Myracle AD, Diaz-Maldonado N, Rochelle NS, Janle EM, Regnier FE. Differential carbonylation of proteins as a function of in vivo oxidative stress. J Proteome Res. 2011;10(9):3959-72. https://doi.org/10.1021/pr200140x PMid:21800835 DOI: https://doi.org/10.1021/pr200140x

Lang F, Lang E, Föller M. Physiology and pathophysiology of eryptosis. Transfus Med Hemother. 2012;39(5):308-14. https://doi.org/10.1159/000342534 PMid:23801921 DOI: https://doi.org/10.1159/000342534

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Published

2021-07-02

How to Cite

1.
Zhumakayeva S, Muravlyova L, Sirota V, Molotov-Luchansky V, Bakirova R, Kabildina N, Mkhitaryan X, Zhumakayeva A. The Reactive Carbonyl Derivatives of Proteins, Methylglyoxal, and Malondialdehyde in Blood of Women with Breast Cancer. Open Access Maced J Med Sci [Internet]. 2021 Jul. 2 [cited 2021 Sep. 20];9(B):509-14. Available from: https://oamjms.eu/index.php/mjms/article/view/5564

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