The Reactive Carbonyl Derivatives of Proteins, Methylglyoxal, and Malondialdehyde in Blood of Women with Breast Cancer

Sabina Zhumakayeva; Larissa  Muravlyova; Valentina  Sirota; Vilen Molotov-Luchansky; Ryszhan Bakirova; Nailya  Kabildina; Xeniya  Mkhitaryan; Ainura Zhumakayeva

doi:10.3889/oamjms.2021.5564

Authors

Sabina Zhumakayeva Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan https://orcid.org/0000-0001-7072-554X
Larissa Muravlyova Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
Valentina Sirota Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
Vilen Molotov-Luchansky Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
Ryszhan Bakirova Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
Nailya Kabildina Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan
Xeniya Mkhitaryan Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan https://orcid.org/0000-0002-7142-7656
Ainura Zhumakayeva Department of Oncology and Radiation Diagnostics, School of Medicine, Karaganda Medical University, Karaganda, Kazakhstan

DOI:

https://doi.org/10.3889/oamjms.2021.5564

Keywords:

Breast cancer, Oxidative stress, Malondialdehyde

Abstract

BACKGROUND: Every year 1.5 million women in the world are diagnosed with breast cancer (BC). In 2018, more than 260,000 new cases of cancer and more than 40,000 deaths due to this disease were detected. At the same time, in Kazakhstan, an intensive indicator of the incidences of BC in 2018 amounted to 25.3% per population of 100 thousand people (2017–24.5%) with a growth rate of 3.1%, which in absolute numbers are 4,648 new cases per year. In terms of mortality, BC ranks third after lung and stomach cancer (6.8%).

AIM: This necessitates a detailed study of the molecular mechanisms that underlie the development and progression of BC. One of the mechanisms of carcinogenesis is oxidative stress (OS). An increase in malondialdehyde (MDA) levels was detected in the early stages of cancer. It was suggested that MDA, due to its high cytotoxicity, acts as a promoter of the tumor and cocarcinogen agent.

METHODS: Therefore, violation of the parameters of OS in BC is in no doubt. However, according to the literature data analysis, these results are ambiguous and contradictory. There are no studies on a comprehensive assessment of the oxidative destruction of lipids, proteins, and nucleic acids in BC.

CONCLUSION: The nature and direction of changes in various components of OS in patients with BC have not been adequately studied, which is necessary for a correct assessment of the involvement of OS in the mechanism of the pathological process and determination of a sensitive marker of the risk of BC or its progression.

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