Corticosteroid Therapy for Brain Tumor Patients with Adrenal Insufficiency

Irwan Barlian  Immadoel Haq; Dirga Rachmad Aprianto; Rahadian Indarto Susilo; Joni Wahyuhadi

doi:10.3889/oamjms.2021.5597

Authors

Irwan Barlian Immadoel Haq Department of Neurosurgery, Faculty of Medicine, Airlangga University, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Dirga Rachmad Aprianto Departement of Surgery, Medical College, Universitas Islam Sultan Agung, Semarang, Indonesia
Rahadian Indarto Susilo Department of Neurosurgery, Faculty of Medicine, Airlangga University, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Joni Wahyuhadi Department of Neurosurgery, Faculty of Medicine, Airlangga University, Dr. Soetomo Academic General Hospital, Surabaya, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.5597

Keywords:

corticosteroid, brain tumor, insufficiency

Abstract

The use of corticosteroids in cases of brain tumors has become common to reduce brain edema. However, the use can cause adrenal insufficiency (AI) if used long-term and in large doses and with rapid withdrawal. In cases of pituitary macroadenoma that has undergone surgery, AI may also occur. AI also affects the treatment of brain tumor patients. Hence, AI is an important problem in brain tumors because almost all patients with brain tumors receive corticosteroids at some point in the course of their disease. The management is similar to another AI with focus of hydrocortisone treatment. The adjustment of hydrocortisone dosage in patients whom undergo brain surgery is similar with another major surgery, whether the adjustment for pituitary adenoma patients whom undergo excision is more complicated and careful due to the high risk and incidence of AI in these patients.

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