Findings of Serial Computed Tomography Imaging in Patients with Coronavirus Disease-19

Masoomeh Raoufi; Shahram Kahkouee; Jamileh Bahri; Neda Khalili; Farzaneh Robatjazi; Nastaran Khalili

doi:10.3889/oamjms.2020.5631

Authors

Masoomeh Raoufi Department of Radiology, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Shahram Kahkouee National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Jamileh Bahri Department of Radiology, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Neda Khalili School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity In Infection, Malignancy and Autoimmunity, Universal Scientific Education and Research Network, Tehran, Iran https://orcid.org/0000-0001-8415-8996
Farzaneh Robatjazi Department of Radiology, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Nastaran Khalili School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity In Infection, Malignancy and Autoimmunity, Universal Scientific Education and Research Network, Tehran, Iran

DOI:

https://doi.org/10.3889/oamjms.2020.5631

Keywords:

COVID-19, coronavirus disease-2019, computed tomography, organizing pneumonia, serial imaging

Abstract

AIM: We investigated the serial changes of chest computed tomography (CT) in patients with coronavirus disease-2019 (COVID-19) presenting with viral-induced lung damage on follow-up CT.

METHODS: We evaluated 66 patients with confirmed COVID-19, who had undergone at least two chest CTs from February 24 to April 21, 2020. Nine patients also had a third CT. All patients demonstrated viral-induced lung damage (organizing pneumonia-like pattern) on second CT. The involvement pattern of each lobe and the extent of infiltration (based on CT score) were assessed on serial CTs to determine changes throughout the disease course. Patients’ demographic and clinical data and final outcome were also recorded.

RESULTS: Mean age (standard deviation [SD]) of patients was 56.04 (15.2) years old; 51.5% were male. About 93.9% of patients had survived. Mean (SD) interval between the first and second CT and second and third CT was 7.6 (5.9) and 16.8 (8.3) days, respectively. The extent of total lung involvement was significantly higher in the second CT compared with the first CT (p < 0.001) and also increased non-significantly in the third CT (p = 0.29). The right lower lobe persistently had the highest CT score through the disease course.

CONCLUSION: Evaluation of serial CT imaging can reveal information regarding the stage of COVID-19, thus providing help for appropriate treatment planning.

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