Irisin in Adolescent Type 1 Diabetic Patients and its Relation to Diabetes Control and Atherosclerosis

Soha M. El Dayem; Ahmed A. Battah; Abo El Magd El Bohy; Rasha Nazih Yousef; Mai Magdy Abd El Wahed Mohamed

doi:10.3889/oamjms.2020.5640

Authors

Soha M. El Dayem Department of Pediatrics, National Research Centre, Cairo, Egypt
Ahmed A. Battah Department of Critical Care, Cairo University, Cairo, Egypt
Abo El Magd El Bohy Department of Radiology, Cairo University, Cairo, Egypt
Rasha Nazih Yousef Department of Clinical Pathology, National Research Centre, Cairo, Egypt
Mai Magdy Abd El Wahed Mohamed Department of Clinical and Chemical Pathology, National Research Centre, Cairo, Egypt

DOI:

https://doi.org/10.3889/oamjms.2020.5640

Keywords:

Irisin, cIMT, HbA1c, type 1 diabetes

Abstract

AIM: The objective of this was to determine the role of irisin in adolescent type 1 diabetes (T1D) patients.

METHODS: This study was conducted on 65 patients with T1D and 50 healthy individuals as control group. Serum irisin, glycosylated hemoglobin (HbA1c), lipid profile, oxidized low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio; carotid intimal medial thickness (cIMT), and aortic intimal medial thickness (aIMT) were evaluated for all participant.

RESULTS: HbA1c, lipid profile, albumin/creatinine ratio, OxLDL, irisin, aIMT and cIMT were significantly higher in diabetic patients. Irisin had a positive correlation with age of diabetic patients, onset of diabetes, mid arm circumference, waist/height ratio, body mass index, HbA1c, and cIMT.

CONCLUSION: Irisin is a marker for detection of diabetes control and early detection of subclinical atherosclerosis. Irisin had a relation with obesity.

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