Effect of Different Remineralizing Agents on White Spot Lesions

Authors

  • Ebaa Alagha Assistant Professor of Operative Dentistry, Department of Restorative Dentistry, Al-Farabi Private Colleges, Jeddah, Saudi Arabia
  • Amira Mohammad Samy Lecturer of Operative Dentistry, School of Oral and Dental Medicine, Badr University, Badr City, Egypt

DOI:

https://doi.org/10.3889/oamjms.2021.5662

Keywords:

Caries, Casein phosphopeptide-amorphous calcium phosphate varnish, Diagnodent, Remineralization, Tricalcium phosphate varnish

Abstract

AIM: This study evaluated the impact of two remineralizing agents containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and tricalcium phosphate (TCP) on white spot lesions.

MATERIALS AND METHODS: A total of 90 freshly extracted upper premolars were divided in three equal groups (30 each): Group A: Control group, Group B: Varnish containing CPP-ACP, and Group C: Varnish containing TCP. The teeth were subjected to Diagnodent test after inducing white spot lesions to assess any surface changes present on the teeth. The readings were repeated post-demineralization and post-remineralization.

RESULTS: Statistically significant difference was present in the mean values between the tested groups. CPP-ACP group recorded higher mean value at demineralization when compared to TCP group. Statistically significant difference (p < 0.00`01) was present between the baseline and the demineralization values. CPP-ACP group presented higher remineralization results when compared to TCP group. T-test proved a significant difference between the tested groups.

CONCLUSION: CPP-ACP containing varnish had higher remineralizing effect when compared to TCP containing varnish.

CLINICAL SIGNIFICANCE: Recently, the focus of restorative dentistry has been directed toward a conservative approach. Prevention and non-restorative treatment of initial enamel caries is the main concern. Remineralization procedures are the most preferred way of regeneration of lost tooth structure.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Yazicioğlu O, Yaman B, Güler A, Koray F. Quantitative evaluation of the enamel caries which were treated with casein phosphopeptideamorphous calcium fluoride phosphate. Niger J Clin Pract. 2017;20(6):686-92. https://doi.org/10.4103/1119-3077.180073 PMid:28656922

Ragendran R, Kunjusankaran R, Sandhya R, Anilkumar A, Santhosh R, Patil S. Comparative evaluation of remineralizing potential of a paste containing bioactive glass and a topical cream containing casein phosphopeptide-amorphous calcium phosphate: An in vitro study. Pesq Bras Odontol Clin Int. 2019;19: 1-10. https://doi.org/10.4034/pboci.2019.191.61

Varma V, Hegde K, Bhat S, Sargod S, Rao H. Comparative evaluation of remineralization potential of two varnishes containing CPP-ACP and tricalcium phosphate: An in vitro study. Int J Clin Pediatr Dent. 2019;12:233-6. https://doi.org/10.5005/jp-journals-10005-1629 PMid:31708621

Dai Z, Liu M, Ma Y, Cao L, Xu H, Zhang K, et al. Effects of fluoride and calcium phosphate materials on remineralization of mild and severe white spot lesions. BioMed Res Int. 2019;16:1271523. https://doi.org/10.1155/2019/1271523

Singh S, Singh1 S, Goyal A, Utreja A, Jena A. Effects of various remineralizing agents on the outcome of post-orthodontic white spot lesions (WSLs): A clinical trial. Prog Orthod. 2016;17(1):17-25. https://doi.org/10.1186/s40510-016-0138-9 PMid:27480987

Babu KG, Subramaniam P, Teleti S. Remineralization potential of varnish containing casein phosphopeptides-amorphous calcium phosphate with fluoride and varnish containing only fluoride: A comparative study. Saudi J Oral Sci. 2018;5(1):35. https://doi.org/10.4103/sjos.sjoralsci_44_17

Jayarajan J, Janardhanam P, Jayakumar P, Deepika. Efficacy of CPPACP and CPPACPF on enamel remineralization an in vitro study using scanning electron microscope and DIAGNOdent. Ind J Dent Res. 2011;22(1):7782. https://doi.org/10.4103/0970-9290.80001 PMid:21525682

Rajan R, Krishnan R, Bhaskaran B, Kumar S. A Polarized light microscopic study to comparatively evaluate four remineralizing agents on enamel viz CPP-ACPF, ReminPro, SHY-NM and colgate strong teeth. Int J Clin Pediatr Dent. 2015;8(1):42-7. https://doi.org/10.5005/jp-journals-10005-1281 PMid:26124580

Rirattanapong P, Vongsavan K, Saengsirinavin C, Pornmahala T. Effect of fluoride varnishes containing tri-calcium phosphate sources on remineralization of initial primary enamel lesions. Southeast Asian J Trop Med Public Health. 2014;45(2):499-504. PMid:24968692

Tahmasbi S, Mousavi S, Behroozibakhsh M, Badiee M. Prevention of white spot lesions using three remineralizing agents: An in vitro comparative study. J Dent Res Dent Clin Dent Prospects. 2019;13(1):36-42. https://doi.org/10.15171/joddd.2019.006 PMid:31217917

Patil N, Choudhari S, Kulkarni S, Joshi S. Comparative evaluation of remineralizing potential of three agents on artificially demineralized human enamel: An in vitro study. J Conserv Dent. 2013;16(2):116-20. https://doi.org/10.4103/0972-0707.108185 PMid:23716961

Tahmasbi S, Adhami M, Valian A, Hamedi R. Effect of three different remineralizing agents on white spot lesions: An in vitro comparative study. J Islam Dent Assoc Iran 2016;28(3):98-103. https://doi.org/10.30699/jidai.29.3.98

Yadav J, Desai H, Patel K, Patel N, Iyengar S. A comparative quantitative and qualitative assessment in orthodontic treatment of white spot lesion treated with 3 different commercially available materials in vitro study. J Clin Exp Dent. 2019;11(9):e776-82. https://doi.org/10.4317/jced.56044 PMid:31636868

Bahrololoomi Z, Musavi S, Kabudan M. In vitro evaluation of the efficacy of laser fluorescence (DIAGNOdent) to detect demineralization and remineralization of smooth enamel lesions. J Conserv Dent. 2013;16(4):362-6. https://doi.org/10.4103/0972-0707.114360 PMid:23956542

El-zankalouny S, Abd El Fattah W, El-Shabrawy S. Penetration depth and enamel microhardness of resin infiltrant and traditional techniques for treatment of artificaial enamel lesions. Alexandria Dent J. 2016;41:20-5. https://doi.org/10.21608/adjalexu.2016.59167

Goel A, Chawla HS, Gauba K, Goyal A. Comparison of validity of DIAGNOdent with conventional methods for detection of occlusal caries in primary molars using the histological gold standard: An in vivo study. J Indian Soc Pedod Prev Dent. 2009;27(4):227-34. https://doi.org/10.4103/0970-4388.57658 PMid:19915274

Lussi A, Megert B, Longbottom C, Reich E, Francescut P. Clinical performance of a laser fluorescence device for detection of occlusal caries lesions. Eur J Oral Sci. 2001;109(1):14-9. https://doi.org/10.1034/j.1600-0722.2001.109001014.x PMid:11330928

Reema S, Lahiri P, Roy S. Review of casein phosphopeptides-amorphous calcium phosphate. Chin J Dent Res. 2014;17(1):7-14. PMid:25028684

Bailey D, Adams G, Tsao C, Hyslop A, Escobar K, Manton DJ, et al. Regression of post-orthodontic lesions by a remineralizing cream. J Dent Res. 2009;88(12):1148-53. https://doi.org/10.1177/0022034509347168 PMid:19887683

Karlinsey R, Mackey A, Stookey G, Pfarrer A. In vitro assessments of experimental NaF dentifrices containing a prospective calcium phosphate technology. Am J Dent. 2009;22(3):180-4. PMid:19650601

Cury J, Tenuta L. Enamel remineralization: Controlling the caries disease or treating early caries lesions? Braz Oral Res. 2009;23(1):23-30. https://doi.org/10.1590/s1806-83242009000500005 PMid:19838555

Ma X, Lin X, Zhong T, Xie F. Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: A systematic review and meta-analysis. BMC Oral Health. 2019;19(1):295. https://doi.org/10.21203/rs.2.13495/v3 PMid:31888600

Cross K, Huq N, Stanton D, Sum M, Reynolds E. NMR studies of a novel calcium, phosphate and fluoride delivery vehicle alphs (S1)-casein (59-79) by stabilized amorphous calcium fluoride phosphate nanocomplexes. Biomaterials. 2004;25(20):5061-9. https://doi.org/10.1016/j.biomaterials.2004.01.045 PMid:15109869

Temel S, Kaya B. Diagnosis, prevention and treatment of white spot lesions related to orthodontics. Int J Oral Dent Health. 2019;5(2):1-7.

Kamath P, Nayak R, Kamath S, Pai D. A comparative evaluation of the remineralization potential of three commercially available remineralizing agents on white spot lesions in primary teeth: An in vitro study. J Indian Soc Pedod Prev Dent. 2017;35(3):229- 37. https://doi.org/10.4103/jisppd.jisppd_242_16 PMid:28762349

Bajaj A, Poornima P, Praveen S, Nagaveni N, Roopa K, Neena I, et al. Comparison of CPP-ACP, Tri-Calcium phosphate and hydroxyapatite on remineralization of artificial caries like lesions on primary enamel an in vitro study. J Clin Pediatr Dent. 2016;40(5):404-9. https://doi.org/10.17796/1053-4628-40.5.404 PMid:27617382

Vyavhare S, Sharma D, Kulkarni V. Effect of three different pastes on remineralization of initial enamel lesion: An in vitro study. J Clin Pediatr Dent. 2015;39(2):149-60. https://doi.org/10.17796/jcpd.39.2.yn2r54nw24l03741 PMid:25823485

Ebrahimi M, Mehrabkhani M, Ahrari F, Parisay I, Jahantigh M. The effects of three remineralizing agents on regression of white spot lesions in children: A two-week, single-blind, randomized clinical trial. J Clin Exp Dent. 2017;9(5):641-8. https://doi.org/10.4317/jced.53582 PMid:28512540

Damyanova D. In vitro study of the effects of fluoride-releasing dental materials on re-mineralization of deciduous teeth. IOSR J Dent Med Sci 2016;15(7):98-101. https://doi.org/10.9790/0853-1507898101

Majithia U, Venkataraghavan K, Choudhary P, Trivedi K, Shah S, Virda M. Comparative evaluation of application of different fluoride varnishes on artificial early enamel lesion: An in vitro study. Indian J Dent Res 2016;27(5):521-7. https://doi.org/10.4103/0970-9290.195642 PMid:27966511

Cochrane N, Shen P, Yuan Y, Reynolds E. Ion release from calcium and fluoride containing dental varnishes. Aust Dent J. 2014;59(1):100-5. https://doi.org/10.1111/adj.12144 PMid:24494654

Savas S, Kavrìk F, Kucukyìlmaz E. Evaluation of the remineralization capacity of CPP ACP containing fluoride varnish by different quantitative methods. J Appl Oral Sci. 2016;24(3):198- 203. https://doi.org/10.1590/1678-775720150583 PMid:27383699

Karabekiroğlu S, Ünlü N, Küçükyilmaz E, Şener S, Botsali MS, Malkoç S. Treatment of post-orthodontic white spot lesions with CPP-ACP paste: A three year follow up study. Dent Mat J. 2017;36(6):791-7. https://doi.org/10.4012/dmj.2016-228 PMid:28835597

Robertson M, Kau C, English J, Lee R, Powers J, Nguyen J. MI Paste Plus to prevent demineralization in orthodontic patients: A prospective randomized controlled trial. Am J Orthop Dentofacial Orthop. 2011;140(5):660-8. https://doi.org/10.1016/j.ajodo.2010.10.025

Reynolds E, Cai F, Cochrane N, Shen P, Walker G, Morgan M. Fluoride, and casein phosphopeptide- amorphous calcium phosphate. J Dent Res. 2008;87(4):344-8. https://doi.org/10.1177/154405910808700420 PMid:18362316

Downloads

Published

2021-01-21

How to Cite

1.
Alagha E, Samy AM. Effect of Different Remineralizing Agents on White Spot Lesions. Open Access Maced J Med Sci [Internet]. 2021 Jan. 21 [cited 2021 Dec. 4];9(D):14-8. Available from: https://oamjms.eu/index.php/mjms/article/view/5662

Issue

Section

Prosthodontics

Categories